检验医学 ›› 2012, Vol. 27 ›› Issue (6): 471-474.

• 微生物学检验论著 • 上一篇    下一篇

老年患者医院感染病原菌分布及其耐药性分析

李姗媚1,缪瑾2,黄雅萍3,徐银萍1,苏瑾2,王蓉3,余平1,徐惠金2,郑国敏1   

  1. 1.黄浦区中西医结合医院院感科,上海 200010;2. 黄浦区中心医院院感科,上海200002;3.市二医院院感科,上海200010;4.黄浦区中西医结合医院检验科,上海 200010;5.黄浦区中心医院检验科,上海200002;6.市二医院检验科,上海 200010
  • 收稿日期:2012-03-21 修回日期:2012-04-15 出版日期:2012-06-30 发布日期:2012-06-06
  • 通讯作者: 李姗媚
  • 作者简介:李姗媚,女,1976年生,学士,主管技师,主要从事微生物检验及医院感染管理工作。
  • 基金资助:

    上海市黄浦区科技攻关项目(2009-HGG-25)

Pathogenic bacterium distribution of elderly patients with nosocomial infection and drug resistance analysis

  1. 1. Department of Infectious Disease, Shanghai Huangpu Integrated Traditional Chinese Medicine and Western Medicine Hospital, Shanghai 200010, China; 2. Department of Infectious Disease, Huangpu Central Hospital, Shanghai 200002, China; 3. Department of Infectious Disease, Shanghai Second People′s Hospital, Shanghai 200010, China; 4. Department of Clinical Laboratory, Shanghai Huangpu Integrated Traditional Chinese Medicine and Western Medicine Hospital, Shanghai 200010, China; 5. Department of Clinical Laboratory, Huangpu Central Hospital, Shanghai 200002, China; 6. Department of Clinical Laboratory, Shanghai Second People′s Hospital, Shanghai 200010, China
  • Received:2012-03-21 Revised:2012-04-15 Online:2012-06-30 Published:2012-06-06

摘要: 目的 分析老年患者医院感染病原菌分布及耐药性,为临床医师合理使用抗菌药物提供依据。方法 对2009年1月至2010年12月黄浦区3家二级综合性医院老年住院患者院内感染送检的各类标本检测,并对分离出的病原菌进行菌株鉴定及耐药性分析。结果 369例老年患者医院感染标本中共检出179株病原菌,其中革兰阴性菌120株占67.0%,革兰阳性菌38株占21.2%,真菌21株占11.8%;其中大肠埃希菌、鲍曼不动杆菌对碳青霉烯类药物耐药率分别达到11.1%、14.2%。革兰阳性菌对青霉素类、第三代头孢耐药性逐步上升。结论 老年患者医院感染病原菌主要为条件致病菌,以革兰阴性杆菌为主,耐药性高,真菌感染所占比例上升较快。因此,重视病原学检查及药敏监测,有助于临床合理选择和使用抗菌药物。

关键词: 老年患者, 医院感染, 耐药率

Abstract: Objective To analyze the pathogenic bacterium distribution of elderly patients with nosocomial infection and drug resistance,and provide the reference for reasonable clinical use of antibacterial drugs.  Methods In Huangpu District 3 secondary general hospitals from January 2009 to December 2010,the specimens were collected from elderly patients with nosocomial infection,and determined for the analysis of pathogenic bacterium identification and drug resistance.  Results In 369 cases of elderly patients with nosocomial infection, a total of 179 strains of pathogenic bacterium were detected, including 120 gram-negative bacteria (67.0%),38 gram-positive bacteria (21.2%) and 21 fungi (11.8%). The drug resistant rates of Escherichia coli and Acinetobacter baumannii to carbapenems were 11.1% and 14.2% respectively. The resistance of gram-positive bacteria to penicillins and third generation cephalosporin increased gradually.  Conclusions Pathogens of elderly patients with nosocomial infection are opportunistic,mainly as gram-negative bacilli. The resistance is high, and the proportion of fungal infection rapidly rises. Therefore,etiological examination and medicine sensitive monitoring should be paid attention,and they will contribute to the clinical rational selection and use of antibacterial drugs.

Key words: Elderly patient, Nosocomial infection, Drug resistant rate