关键词: 子痫前期, 血小板, 纤维蛋白原, D-二聚体

Abstract: Objective　To investigate the predictive significance on the detection of coagulation andfibrinolysis related items among pregnant women during their 32-33 gestational weeksfor late on set preeclampsia.   Methods　A total of 2 562 singleton primiparous pregnant women were enrolled，and peripheral blood was taken during 32-33 gestational weeks to determine platelet（PLT），hemoglobin（HGB），fibrinogen（Fib） and D-dimer（DD） levels. The 154 among 2 562 pregnant women developed preeclampsia after regularfollow up of all pregnant women till delivery. Results　The levels of PLT andfib in preeclampsia group were higher those that of the normal pregnant group with statistical significance（P=0.000、0.020）. There was no significant difference between the 2 groups of HGB and DD levels. The elevation of plasmafib and PLT levels could predict the late on set preeclampsia [odds ratio（OR）=1.47，95% confidence interval（CI） 1.23-1.76；OR=1.30，95% CI 1.13-1.41，P＜0.05]. The DD level had no statistical significance to predict he late on set preeclampsia（OR=1.07，95% CI 0.90-1.28，P＞0.05）. Conclusions　The PLT andfib levels to predict the late on set preeclampsia should befurther investigated.

Key words: Preeclampsia, Platelet, Fibrinogen, D-dimer