关键词: 血管生成素-1, 血红素氧化酶1, 神经生长因子, 高血压脑出血, 认知障碍

Abstract:

Objective To evaluate the efficacy of angiopoietin-1（Ang-1），heme oxygenase 1（HO-1），nerve growth factor （NGF） and Mini-Mental State Examination（MMSE）score in hypertensive intracerebral hemorrhage （HICH）. Methods Totally，152 patients with HICH（HICH group）and 68 healthy subjects （healthy control group） were enrolled from Zhangjiakou First Hospital from February 2018 to February 2022. All the patients were treated with bone flap hematoma removal，supportive therapy and brain proteolytic hydrolysate. According to the efficacy，they were classified into effective group （105 cases） and ineffective group （47 cases）. Serum Ang-1，HO-1 and NGF levels of HICH and healthy groups before and after treatment were determined，and MMSE scores were used to evaluate the cognitive function of HICH patients. Multivariate Logistic regression analysis was used to evaluate the risk factors of HICH treatment failure. Receiver operating characteristic （ROC） curve was used to evaluate the efficacy of Ang-1，HO-1，NGF and MMSE scores in judging the therapeutic effect of HICH. Results Before treatment，serum Ang-1，NGF and MMSE scores in HICH group were lower than those in healthy control group （P<0.05），and serum HO-1 levels in HICH group were higher than those in healthy control group （P<0.05）. After treatment，serum Ang-1，NGF and MMSE scores in effective group were higher than those before treatment （P<0.05），and serum HO-1 levels were lower（P<0.05）. There was no statistical significance between the 2 groups before and after treatment （P>0.05）. Serum Ang-1，NGF levels and MMSE scores in ineffective group were lower than those in effective group before and after treatment （P<0.05），and serum HO-1 levels were higher than those in effective group （P<0.05）. Grade 3 hypertension and pre-treatment increase of HO-1，decrease of Ang-1，decrease of NGF and decrease of MMSE scores were risk factors for treatment ineffectiveness in patients with HICH [odds ratios （OR） were 2.324，1.442，0.549，0.671 and 0.716，95% confidence intervals （CI） were 1.357-5.468，1.203-4.535，0.211-0.884，0.316-0.854 and 0.461-0.973，respectively，P<0.05]. The areas under curves （AUC） of serum Ang-1，HO-1，NGF levels and MMSE scores and combined determination to judge the treatment efficacy of HICH were 0.859，0.848，0.856，0.820 and 0.958. Conclusions Serum Ang-1，NGF and HO-1 levels are related to the clinical efficacy of patients with HICH，and they may be used as potential indicators for the efficacy evaluation of HICH.

Key words: Angiopoietin-1, Heme oxidase 1, Nerve growth factor, Hypertensive intracerebral hemorrhage, Cognitive impairment