光滑念珠菌耐药机制及中西药治疗光滑念珠菌感染研究进展

doi:10.3969/j.issn.1673-8640.2021.07.018

摘要/Abstract

摘要：

光滑念珠菌是临床最常见的非白念珠菌,对唑类药物的耐药率逐年增高,为念珠菌病的临床治疗带来一定的困难。光滑念珠菌相关耐药基因研究发现,生物膜相关基因和外排基因等的表达与其耐药密切相关。为解决光滑念珠菌耐药问题,临床采用中西药结合的方法,为光滑念珠菌感染的临床治疗提供了新的途径。文章对光滑念珠菌耐药机制及中西药治疗光滑念珠菌感染的研究进展进行综述,以期为临床治疗光滑念珠菌感染提供参考。

关键词: 光滑念珠菌, 生物膜, 中西药结合, 药物外排, 耐药基因

Abstract:

Candida glabrata is the most common non-Candida albicans,and its resistance rate to azoles is increasing year by year,which brings certain difficulty for the clinical treatment of candidiasis. Studies on genes related to resistance of Candida glabrata find that biofilm-related genes and efflux genes are closely related to drug resistance. In order to solve the problem of drug resistance,the drug resistance mechanism of Candida glabrata and the combination of traditional Chinese medicine in the modern clinical treatment of Candida glabrata infection provides a approach of therapy for the clinical treatment of Candida glabrata infection.

Key words: Candida glabrata, Biofilm, Chinese and western medicine treatment, Drug efflux, Drug resistance gene

中图分类号:

R379.4

张冠怡, 姚冬婷, 王健, 胡晓波. 光滑念珠菌耐药机制及中西药治疗光滑念珠菌感染研究进展[J]. 检验医学, 2021, 36(7): 761-765.

ZHANG Guanyi, YAO Dongting, WANG Jian, HU Xiaobo. Research progress on Chinese and western medicine treatment for Candida glabrata infection[J]. Laboratory Medicine, 2021, 36(7): 761-765.

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