外泌体在消化道肿瘤转移中的研究进展

doi:10.3969/j.issn.1673-8640.2020.12.004

摘要/Abstract

摘要：

外泌体是直径为30~100 nm的囊泡样小体,通过将其携带的蛋白质、微小RNA（miRNA）、长链非编码RNA（lncRNA）等传递至受体细胞,介导细胞间信号传递。消化道肿瘤是发病率与死亡率均较高的恶性肿瘤,肿瘤转移是造成患者死亡的主要原因。外泌体在消化道肿瘤转移过程中发挥了关键作用,能通过靶向上皮间质转化、血管生成、肿瘤微环境等调控肿瘤转移。文章对外泌体在调控上皮间质转化、血管生成和肿瘤微环境中的作用进行综述,为消化道肿瘤转移机制的研究提供新的思路。

关键词: 外泌体, 消化道肿瘤, 转移

Abstract:

Exosomes are sorts of small extracellular vesicles ranging approximately from 30 nm to 100 nm in diameter,which can serve as carriers transporting protein,microRNA（miRNA）,long non-coding RNA（lncRNA） and others to target cells,further mediating cell communication. Gastrointestinal cancer is a malignant cancer with high morbidity and mortality,and cancer metastasis is the main cause of death. Exosome play a key role in the process of gastrointestinal cancer metastasis by targeting epithelial-mesenchymal transition,angiogenesis,tumor microenvironment and so on. This review summarizes the role of exosomes in regulating epithelial-mesenchymal transition,angiogenesis and tumor microenvironment,which may provide new ideas for the study of gastrointestinal cancer metastasis.

Key words: Exosome, Gastrointestinal cancer, Metastasis

中图分类号:

R446.1

陈佳, 金炜, 胡晓波. 外泌体在消化道肿瘤转移中的研究进展[J]. 检验医学, 2020, 35(12): 1220-1223.

CHEN Jia, JIN Wei, HU Xiaobo. Research progress of exosomes in gastrointestinal cancer metastasis[J]. Laboratory Medicine, 2020, 35(12): 1220-1223.

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