RDW在恶性肿瘤诊疗中的最新应用

doi:10.3969/j.issn.1673-8640.2018.09.017

摘要/Abstract

摘要：

红细胞分布宽度（RDW）是反映红细胞体积大小异质性的参数,以往主要应用于贫血的诊断。在过去一段时间里,已经有大量的研究数据表明RDW在心血管疾病、高血压、炎症性肠病及自身免疫性疾病等多种疾病中具有应用价值。近年来,有越来越多的研究开始报道RDW在恶性肿瘤中的诊断价值,文章就RDW在各类肿瘤临床诊断中的研究进展作一综述。

关键词: 红细胞分布宽度（RDW）, 恶性肿瘤, 临床诊断

Abstract:

Red cell distribution width （RDW） is a parameter that reflects the size variability of erythrocytes,mainly used in the diagnosis of anemia. In recent studies,RDW has been associated with cardiovascular diseases,hypertension,inflammatory bowel diseases and autoimmune diseases. In recent years,more and more studies have begun to report the diagnostic role of RDW in malignant tumors. This review focuses on the research progress of RDW in the clinical diagnosis of tumors.

Key words: Red cell distribution width, Malignant tumor, Clinical diagnosis

中图分类号:

R446.1

杨滇宇, 权文强, 孙祖俊, 李冬. RDW在恶性肿瘤诊疗中的最新应用[J]. 检验医学, 2018, 33(9): 844-549.

YANG Dianyu, QUAN Wenqiang, SUN Zujun, LI Dong. Research progress in RDW for the diagnosis and treatment of malignant tumors[J]. Laboratory Medicine, 2018, 33(9): 844-549.

参考文献 37

[1]	ZALAWADIYA S K,VEERANNA V,NIRAJ A, et al.Red cell distribution width and risk of coronary heart disease events[J]. Am J Cardiol,2010,106(7):988-993.
[2]	TONELLI M,SACKS F, ARNOLD M, et al.Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease[J]. Circulation,2008,117(2):163-168.
[3]	LIPPI G, TARGHER G, MONTAGNANA M, et al.Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients[J]. Arch Pathol Lab Med, 2009,133(4):628-632.
[4]	GRIVENNIKOV S I, GRETEN F R, KARIN M.Immunity,inflammation,and cancer[J]. Cell, 2010,140(6): 883-899.
[5]	FERLAY J,SOERJOMATARAM I,DIKSHIT R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer,2015,136(5):E359-E386.
[6]	KOMA Y, ONISHI A, MATSUOKA H, et al.Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer[J]. PLoS One, 2013, 8(11):e80240.
[7]	徐阳颺,朱晓,娄加陶. 红细胞分布宽度在肺癌转移中的应用价值[J]. 中华检验医学杂志,2014,37(6):444-446.
[8]	李连弟,鲁凤珠,张思维,等. 中国恶性肿瘤死亡率20年变化趋势和近期预测分析[J]. 中华肿瘤杂志,1997, 19(1): 4-10.
[9]	CHEN G P, HUANG Y, YANG X,et al.A nomogram to predict prognostic value of red cell distribution width in patients with esophageal cancer[J]. Mediators Inflamm,2015, 2015:854670.
[10]	WAN G X, CHEN P, CAI X J, et al.Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma[J]. Clin Chim Acta, 2016,452: 199-203.
[11]	LIN J T.Screening of gastric cancer:who,when,how[J]. Clin Gastroenterol Hepatol,2014,12(1):135-138.
[12]	YAZICI P, DEMIR U, BOZKURT E, et al.The role of red cell distribution width in the prognosis of patients with gastric cancer[J]. Cancer Biomark, 2017,18(1):19-25.
[13]	WEI T T, WANG L L, YIN J R, et al.Relationship between red blood cell distribution width,bilirubin,and clinical characteristics of patients with gastric cancer[J]. Int J Lab Hematol, 2017, 39(5):497-501.
[14]	SMIRNE C, GROSSI G, PINATO D J, et al.Evaluation of the red cell distribution width as a biomarker of early mortality in hepatocellular carcinoma[J]. Dig Liver Dis, 2015,47(6):488-494.
[15]	ZHAO T, CUI L, LI A.The significance of RDW in patients with hepatocellular carcinoma after radical resection[J]. Cancer Biomark, 2016,16(4):507-512.
[16]	GOYAL H, HU Z D.Prognostic value of red blood cell distribution width in hepatocellular carcinoma[J]. Ann Transl Med, 2017,5(13): 271.
[17]	WEI T T, TANG Q Q, QIN B D, et al.Elevated red blood cell distribution width is associated with liver function tests in patients with primary hepatocellular carcinoma[J]. Clin Hemorheol Microcirc, 2016,64(2):149-155.
[18]	PEERY A F, CROCKETT S D, BARRITT A S, et al.Burden of gastrointestinal,liver,and pancreatic diseases in the United States[J]. Gastroenterology, 2015, 149(7):1731-1741.
[19]	YILMAZ A, MALYA F U, OZTURK G, et al.Effect of pre-operative red blood cell distribution on cancer stage and morbidity rate in patients with pancreatic cancer[J]. Int J Clin Exp Med, 2014,7(9):3072-3075.
[20]	CHEN W, ZHENG R, BAADE P D, et al.Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2): 115-132.
[21]	AY S, ERYILMAZ M A, AKSOY N, et al.Is early detection of colon cancer possible with red blood cell distribution width?[J]. Asian Pac J Cancer Prev, 2015,16(2):753-756.
[22]	KUST D, LUCIJANIC M, URCH K, et al.Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer[J]. QJM, 2017,110(6):361-367.
[23]	WANG F M,XU G,ZHANG Y,et al.Red cell distribution width is associated with presence,stage, and grade in patients with renal cell carcinoma[J]. Dis Markers, 2014, 2014:860419.
[24]	JEMAL A,BRAY F,CENTER M M,et a1.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
[25]	ALBAYRAK S, ZENGIN K, TANIK S, et al.Red cell distribution width as a predictor of prostate cancer progression[J]. Asian Pac J Cancer Prev, 2014,15(18):7781-7784.
[26]	韩苏军,张思维,陈万青,等. 中国膀胱癌发病现状及流行趋势分析[J]. 癌症进展,2013,11(1):89-95.
[27]	周杨,于洋,张庆云,等. 红细胞分布宽度对膀胱尿路上皮癌的诊断价值[J]. 广西医科大学学报, 2016, 33(1) : 77-79.
[28]	WHITEHOUSE C, SOLOMON E.Current status of the molecular characterization of the ovarian cancer antigen CA125 and implications for its use in clinical screening[J]. Gynecol Oncol,2003, 88(1 Pt 2): S152-S157.
[29]	OBERAIGNER W,MINICOZZI P,BIELSKA-LASOTA M,et al.Survival for ovarian cancer in Europe: the across-country variation did not shrink in the past decade[J]. Acta Oncol,2012,51(4):441-453.
[30]	QIN Y, WANG P, HUANG Z,et al.The value of red cell distribution width in patients with ovarian cancer[J]. Medicine(Baltimore),2017,96(17):e6752.
[31]	AMANT F, MOERMAN P, NEVEN P,et al.Endometrial cancer[J]. Lancet,2005,366(9484):491-505.
[32]	KEMAL Y, DEMIRAG G, BAS B,et al.The value of red blood cell distribution width in endometrial cancer[J]. Clin Chem Lab Med,2015,53(5):823-827.
[33]	PARKIN D M,BRAY F,FERLAY J,et al.Global cancer statistics,2002[J].CA Cancer J Clin,2005,55(2):74-108.
[34]	SERETIS C, SERETIS F, LAGOUDIANAKIS E, et al.Is red cell distribution width a novel biomarker of breast cancer activity ? Data from a pilot study[J]. J Clin Med Res, 2013, 5(2):121-126.
[35]	HUANG D P, MA R M, XIANG Y Q, et al.Utility of red cell distribution as a prognostic factor in young breast cancer patients[J]. Medicine(Baltimore), 2016, 95(17):e3430.
[36]	FÖRHÉCZ Z, GOMBOS T, BORGULYA G, et al. Red cell distribution width in heart failure:prediction of clinical events and relationship with markers of ineffective erythropoiesis,inflammation,renal function,and nutritional state[J]. Am Heart J, 2009, 158(4):659-666.
[37]	林白桦,吴树强,毕爱红,等. 非小细胞肺癌患者发生贫血的相关因素研究[J]. 实用医学杂志,2010,26(16): 2956-2958.