甲状腺功能亢进型心脏病患者血清甲状腺过氧化物酶抗体、甲状腺球蛋白抗体水平的变化及意义

doi:10.3969/j.issn.1673-8640.2018.09.004

摘要/Abstract

摘要：

目的探讨甲状腺功能亢进型心脏病（HHD）患者血清甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）水平的变化及意义。方法选取HHD患者100例、单纯甲状腺功能亢进症（简称甲亢）患者100例,收集所有患者的一般资料[性别、年龄、体重指数（BMI）、甲亢病程、平均动脉压（MAP）],同时检测其血清TPOAb、TgAb水平。结果 HHD组性别、年龄、BMI、甲亢病程、MAP与甲亢组比较,差异均无统计学意义（P>0.05）。HHD组治疗前后血清TPOAb、TgAb水平均明显高于甲亢组（P<0.001）,HHD组治疗后血清TPOAb、TgAb水平均明显低于治疗前（P<0.001）。HHD组治疗有效76例（76.00%）、治疗无效24例（24.00%）。HHD治疗有效者治疗后血清TPOAb、TgAb水平均明显低于治疗前及治疗无效者（P<0.001）,HHD治疗无效者治疗前后血清TPOAb、TgAb水平差异均无统计学意义（P>0.05）。HHD治疗有效者治疗后血清TPOAb、TgAb水平与甲亢组比较,差异均无统计学意义（P>0.05）。结论血清TPOAb、TgAb水平可能与HHD的发生及转归有关,可作为评估HHD患者疗效的参考指标。

关键词: 甲状腺过氧化物酶抗体, 甲状腺球蛋白抗体, 甲状腺功能亢进型心脏病

Abstract:

Objective To investigate the changes of serum thyroid peroxidase antibody（TPOAb） and thyroglobulin antibody（TgAb） in patients with hyperthyroidism heart disease（HHD）. Methods A total of 100 patients with HHD and 100 patients with hyperthyroidism were enrolled,and their general data [sex,age,body mass index（BMI）,hyperthyroidism course and mean arterial pressure（MAP）] were collected. Serum TPOAb and TgAb levels were determined. Results There was no statistical significance for sex,age,BMI,hyperthyroidism course and MAP between HHD and hyperthyroidism groups （P>0.05）. Serum TPOAb and TgAb levels in HHD group were higher than those in hyperthyroidism group before and after treatment（P<0.001）. In HHD group,serum TPOAb and TgAb after treatment were lower than those before treatment（P<0.001）. There were 76 effective cases （76.00%） and 24 invalid cases（24.00%）in HHD group. After treatment,serum TPOAb and TgAb levels in effective cases were lower than those before treatment and in invalid cases（P<0.001）. For invalid cases,serum TPOAb and TgAb levels had no statistical significance before and after treatment （P>0.05）. Serum TPOAb and TgAb levels in effective cases after treatment had no statistical significance compared with hyperthyroidism group （P>0.05）. Conclusions Serum TPOAb and TgAb levels may be related to the occurrence and transfer of HHD,and they can be used as reference indices for evaluating curative effects.

Key words: Thyroid peroxidase antibody, Thyroglobulin antibody, Hyperthyroidism heart disease

中图分类号:

R446.1

王瑶. 甲状腺功能亢进型心脏病患者血清甲状腺过氧化物酶抗体、甲状腺球蛋白抗体水平的变化及意义[J]. 检验医学, 2018, 33(9): 790-793.

WANG Yao. Changes of serum thyroid peroxidase antibody and thyroglobulin antibody in patients with hyperthyroidism heart disease[J]. Laboratory Medicine, 2018, 33(9): 790-793.

图/表 3

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组别	例数	性别		年龄（岁）	BMI（kg/m²）	甲亢病程（年）	MAP（kPa）
组别	例数	男	女	年龄（岁）	BMI（kg/m²）	甲亢病程（年）	MAP（kPa）
甲亢组	100	60	40	47.57±10.27	24.57±4.21	8.67±3.43	14.66±1.49
HHD组	100	58	42	48.22±10.87	24.68±4.26	8.87±3.50	14.81±1.54
统计值		0.162		0.291	0.130	0.203	0.456
P值		0.918		0.824	0.942	0.887	0.704

组别	例数	性别		年龄（岁）	BMI（kg/m²）	甲亢病程（年）	MAP（kPa）
组别	例数	男	女	年龄（岁）	BMI（kg/m²）	甲亢病程（年）	MAP（kPa）
甲亢组	100	60	40	47.57±10.27	24.57±4.21	8.67±3.43	14.66±1.49
HHD组	100	58	42	48.22±10.87	24.68±4.26	8.87±3.50	14.81±1.54
统计值		0.162		0.291	0.130	0.203	0.456
P值		0.918		0.824	0.942	0.887	0.704