外周血血脂水平与年龄相关性黄斑变性的相关性

doi:10.3969/j.issn.1673-8640.2017.12.007

摘要/Abstract

摘要：

目的探讨年龄相关性黄斑变性（AMD）与血脂的相关性。方法选取AMD患者84例,收集其年龄、性别、疾病史等资料,以体检健康者40名作为正常对照组。分别测定AMD组及正常对照组血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A（apo A）、载脂蛋白B（apo B）水平。对AMD组与正常对照组外周血血脂水平进行单因素及多因素Logistic回归分析。结果 AMD组TC、TG、HDL-C、apo A水平明显高于正常对照组（P<0.05）。多因素Logistic回归分析显示TC[比值比（OR）=2.095,95%可信区间（CI）1.277~3.434]、HDL-C（OR=3.106,95%CI 1.133~8.513）、apo A（OR=3.588,95%CI0.768~16.752）为AMD发病的危险因素。结论外周血TC、HDL-C、apo A水平升高可能与AMD的发病存在相关性。

关键词: 血脂, 危险因素, 年龄相关性黄斑变性

Abstract:

Objective To investigate the correlation between peripheral blood lipid level and age-related macular degeneration（AMD）. Methods A total of 84 AMD patients and 40 healthy subjects were enrolled,and their data of age,sex and disease history were collected. Serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A（apo A） and apolipoprotein B（apo B） were determined. The results were analyzed by univariate analysis and multivariate Logistic regression analysis. Results The levels of TC,TG,HDL-C and apo A in AMD group were higher than those in healthy control group（P<0.05）. Multivariate Logistic regression analysis showed that TC [odds ratio （OR）=2.095,95% confidence interval（CI）1.277-3.434],HDL-C（OR=3.106,95%CI 1.133-8.513） and apo A（OR=3.588,95%CI 0.768-16.752）were risk factors for AMD. Conclusions The increasing levels of peripheral blood TC,HDL-C and apo A may be correlated with the incidence of AMD.

Key words: Blood lipid, Risk factor, Age-related macular degeneration

中图分类号:

R446.1

邵明希, 李圣杰, 曹文俊. 外周血血脂水平与年龄相关性黄斑变性的相关性[J]. 检验医学, 2017, 32(12): 1105-1108.

SHAO Mingxi, LI Shengjie, CAO Wenjun. Correlation between peripheral blood lipid level and age-related macular degeneration[J]. Laboratory Medicine, 2017, 32(12): 1105-1108.

图/表 2

参考文献 21

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组别	例数	年龄（岁）	性别（男/女）	舒张压（kPa）	收缩压（kPa）	BMI（kg/m²）
AMD组	84	51.67±13.96	30/54	10.91±1.14	17.18±1.23	22.55±2.17
正常对照组	40	46.95±14.56	17/23	11.35±1.15	17.71±1.39	23.18±1.66
统计值		1.696	0.530	1.325	1.427	1.105
P值		0.093	0.467	0.191	0.160	0.274

组别	例数	年龄（岁）	性别（男/女）	舒张压（kPa）	收缩压（kPa）	BMI（kg/m²）
AMD组	84	51.67±13.96	30/54	10.91±1.14	17.18±1.23	22.55±2.17
正常对照组	40	46.95±14.56	17/23	11.35±1.15	17.71±1.39	23.18±1.66
统计值		1.696	0.530	1.325	1.427	1.105
P值		0.093	0.467	0.191	0.160	0.274

组别	例数	TC	TG	HDL-C	LDL-C	apo B	apo A
AMD组	84	4.77±1.12	1.38±0.85	1.63±0.61	2.66±1.08	1.05±0.28	1.73±0.35
正常对照组	40	3.98±0.68	1.04±0.38	1.35±0.21	2.79±0.58	0.98±0.16	1.55±0.17
t值		4.771	3.017	3.818	0.909	1.698	3.710
P值		<0.001	0.003	<0.001	0.365	0.092	<0.001

组别	例数	TC	TG	HDL-C	LDL-C	apo B	apo A
AMD组	84	4.77±1.12	1.38±0.85	1.63±0.61	2.66±1.08	1.05±0.28	1.73±0.35
正常对照组	40	3.98±0.68	1.04±0.38	1.35±0.21	2.79±0.58	0.98±0.16	1.55±0.17
t值		4.771	3.017	3.818	0.909	1.698	3.710
P值		<0.001	0.003	<0.001	0.365	0.092	<0.001