关键词: 鼻咽肿瘤, 血小板, 纤维蛋白原, 纤维蛋白原降解产物, D-二聚体, 预后

Abstract:

Objective To investigate the relationships of platelet（PLT）,fibrinogen（Fib）,fibrinogen degradation product（FDP）,D-dimer（DD） with the prognosis of nasopharyngeal carcinoma（NPC）,and to provide a reference on the prognosis of NPC. Methods Blood samples were collected from 113 patients with NPC,30 patients with nasopharynx benign tumor,30 patients with nasopharyngitis and 30 healthy subjects. The levels of Fib,FDP and DD were determined by SYSMEX CA7000 automatic coagulation analyzer,and the count of PLT was determined by BECKMAN-COULTER LH750. Results The levels of Fib,FDP and DD in NPC group were higher than those in nasopharynx benign tumor,nasopharyngitis and healthy control groups（P<0.05）,and the count of PLT was higher than those in nasopharynx benign tumor and healthy control groups（P<0.05）. In NPC group without recurrence within 3 years,the count of PLT and the level of FDP were decreased when they left hospital compared with those being hospitalized（P<0.05）. In NPC group with recurrence within 3 years,the count of PLT and the levels of Fib and FDP were decreased when they left hospital compared with those being hospitalized（P<0.05）. When they were hospitalized again,the count of PLT and the levels of FDP and DD were increased significantly. Compared with those being hospitalized firstly,the levels of FDP and DD were increased as well. Conclusions The determinations of PLT count,Fib,FDP and DD play roles in the prognosis identification of NPC.

Key words: Nasopharyngeal carcinoma, Platelet, Fibrinogen, Fibrinogen degradation product, D-dimer, Prognosis