关键词: 降钙素原, 肝素结合蛋白, 血流感染, 序贯器官衰竭估计评分

Abstract:

Objective To investigate the roles of heparin binding protein（HBP） and procalcitonin（PCT） in the diagnosis of bloodstream infection and the severity of infection. Methods A total of 57 patients with bloodstream infection were enrolled,and 50 healthy subjects and 50 non-bacterial infection patients were enrolled as well. HBP and PCT levels were determined. PCT and HBP levels between Gram-negative and Gram-positive bacteria in bloodstream infection group were compared. Receiver operating characteristic（ROC） curve was used to analyze the efficiency of parameters. Sequential organ failure assessment（SOFA） was performed,and the relationship of SOFA score with PCT and HBP levels was evaluated by SNK method and single factor multiple Logistic regression analysis. Results The levels of PCT and HBP in Gram-negative bacteria were 6.8（4.2-15.6） ng/mL and （105.3±51.8） ng/mL,respectively. The levels of PCT and HBP in Gram-positive bacteria were 6.2（4.5-7.8） ng/mL and （168.1±79.2）ng/mL,respectively. The sensitivities of PCT and HBP for the diagnosis of bloodstream infection were 91.2% and 73.7%,and the specificities were 94.0% and 88.0%,and areas under ROC curves（AUC） were 0.983 and 0.880. The PCT levels in patients with SOFA score 19-24 and 13-18 were higher than those with SOFA score 1-6 and 7-12,and there was no statistical significance between SOFA score 19-24 and 13-18. The HBP levels were increased with SOFA score increasing. Conclusions PCT is superior than HBP in the diagnosis of bloodstream infection,and HBP can predict the severity of infection.

Key words: Procalcitonin, Heparin binding protein, Bloodstream infection, Sequential organ failure assessment score