上海地区老年男性血清25- 羟基维生素D水平与4项血脂指标的相关性

doi:10.3969/j.issn.1673-8640.2016.09.013

摘要/Abstract

摘要：

目的研究老年男性血清25-羟基维生素D [25（OH）D]水平与甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平间的关系。方法研究纳入健康体格检查的老年男性686名,记录年龄、身高、体重等基本信息,收集空腹静脉血,检测4项血脂指标及25（OH）D水平,根据25（OH）D水平进行四分位分组（由高到低依次为G1组、G2组、G3组、G4组）,比较G1组和G4组间影响血脂水平的相关因素,并对25（OH）D与血脂水平的关系进行回归分析。结果G1组体重指数（BMI）明显低于G4组（P=0.001）,而HDL-C水平明显高于G4组（P<0.001）,年龄、LDL-C、TC和TG 2个组间差异均无统计学意义（P>0.05）。HDL-C与25（OH）D呈正相关（R²=0.161 8,P<0.001）。在校正了年龄和BMI后,血清25（OH）D水平每升高10 nmol/L,HDL-C可升高0.01 mmol/L。结论老年男性的HDL-C水平可能受25（OH）D水平的影响。

关键词: 25-羟基维生素D, 血脂, 老年人

Abstract:

Objective To investigate the relationships of serum 25-hydroxyvitamin D [25（OH）D] with triglyceride （TG）,total cholesterol（TC）,high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C） among elderly males in Shanghai. Methods A total of 686 elderly males participating healthy examination were enrolled. Their ages,heights and weights were recorded. Fasting venous blood samples were collected,and the 4 blood lipid levels and 25（OH）D were determined. According to the levels of 25（OH）D ,the classification was performed,G1,G2,G3 and G4 groups. The factors for blood lipid levels between G1 and G4 groups were compared. The correlations of 25（OH）D with blood lipid levels were analyzed regressively. Results Body mass index （BMI） in G1 group was lower than that in G4 group（P=0.001）,and HDL-C in G1 group was higher than that in G4 group（P<0.001）. There was no statistical significance for ages,LDL-C,TC and TG between G1 and G4 groups（P>0.05）. HDL-C was correlated positively with 25（OH）D （R²=0.161 8,P<0.001）. After the adjustment for ages and BMI,HDL-C increased by 0.01 mmol/L with serum 25（OH）D increasing by10 nmol/L. Conclusions HDL-C in elderly males may be affected by 25（OH）D.

Key words: 25-Hydroxyvitamin D, Blood lipid, Elderly

中图分类号:

R446.1

杨静, 宋斌斌, 王蓓丽, 吴炯, 张春燕, 郭玮, 潘柏申. 上海地区老年男性血清25- 羟基维生素D水平与4项血脂指标的相关性[J]. 检验医学, 2016, 31(9): 792-796.

YANG Jing, SONG Binbin, WANG Beili, WU Jiong, ZHANG Chunyan, GUO Wei, PAN Baishen. Correlations between serum 25-hydroxyvitamin D and 4 blood lipid items among elderly males in Shanghai[J]. Laboratory Medicine, 2016, 31(9): 792-796.

图/表 4

参考文献 22

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组别	例数	25（OH）D（nmol/L）	年龄（岁）	BMI （kg/m²）	HDL-C （mmol/L）	LDL-C （mmol/L）	TG （mmol/L）	TC （mmol/L）
G1组	172	86.23±15.72	73.46±9.90	23.39±3.18	1.59±0.44	2.57±0.77	1.75±0.83	4.82±0.85
G2组	171	58.40±5.49	73.46±9.90	23.85±2.95	1.45±0.38	2.70±0.81	1.73±1.02	4.88±0.93
G3组	171	42.62±3.85	71.82±11.81	24.41±3.51	1.45±0.35	2.64±0.78	1.76±1.33	4.82±0.92
G4组	172	27.58±5.95^**	72.81±12.80	24.18±3.40^*	1.44±0.41^**	2.60±0.79	1.75±1.06	4.78±0.93

组别	例数	25（OH）D（nmol/L）	年龄（岁）	BMI （kg/m²）	HDL-C （mmol/L）	LDL-C （mmol/L）	TG （mmol/L）	TC （mmol/L）
G1组	172	86.23±15.72	73.46±9.90	23.39±3.18	1.59±0.44	2.57±0.77	1.75±0.83	4.82±0.85
G2组	171	58.40±5.49	73.46±9.90	23.85±2.95	1.45±0.38	2.70±0.81	1.73±1.02	4.88±0.93
G3组	171	42.62±3.85	71.82±11.81	24.41±3.51	1.45±0.35	2.64±0.78	1.76±1.33	4.82±0.92
G4组	172	27.58±5.95^**	72.81±12.80	24.18±3.40^*	1.44±0.41^**	2.60±0.79	1.75±1.06	4.78±0.93

项目	偏回归系数	标准化偏回归系数	P值
年龄	0.007	0.187	<0.001
BMI	-0.043	-0.355	<0.001
25（OH）D	0.002	0.125	<0.001

项目	偏回归系数	标准化偏回归系数	P值
年龄	0.007	0.187	<0.001
BMI	-0.043	-0.355	<0.001
25（OH）D	0.002	0.125	<0.001

项目	模式	偏回归系数	标准化偏回归系数	P值
年龄	Model1	0.005	0.134	<0.001
BMI	Model2	-0.038	-0.310	<0.001
25（OH）D	Model3	0.001	0.076	<0.001