检验医学 ›› 2016, Vol. 31 ›› Issue (6): 499-502.DOI: 10.3969/j.issn.1673-8640.2016.06.012

• 临床应用研究·论著 • 上一篇    下一篇

北京地区成人呼吸道病毒感染流行病学分析

许宏涛1, 李毅2, 陈东科1, 王和2, 艾效曼1, 陈雪1, 陶凤蓉1, 赖惠英1, 胡云建1, 张秀珍1   

  1. 1.北京医院检验科,北京 100730
    2.北京医院呼吸与危重医学科,北京 100730
  • 收稿日期:2016-01-14 出版日期:2016-06-30 发布日期:2016-07-05
  • 作者简介:null

    作者简介:许宏涛,女,1973年生,博士,主任技师,主要从事感染性疾病病原检测和耐药机制研究。

Epidemiological analysis of respiratory tract viruses among adult patients in Beijing

XU Hongtao1, LI Yi2, CHEN Dongke1, WANG He2, AI Xiaoman1, CHEN Xue1, TAO Fengrong1, LAI Huiying1, HU Yunjian1, ZHANG Xiuzhen1   

  1. 1. Department of Clinical Laboratory,Beijing Hospital,Beijing 100730,China
    2. Department of Respiratory and Critical Care Medicine,Beijing Hospital,Beijing 100730,China
  • Received:2016-01-14 Online:2016-06-30 Published:2016-07-05

摘要:

目的 对北京地区成人呼吸道感染病毒病原体进行流行病学分析。方法 收集2014年4月至2015年3月北京医院门诊及住院的成人呼吸道急性感染患者的鼻咽拭子,应用液态芯片技术(xTAG RVP)对9种呼吸道病毒(含亚型共18种)进行检测,并分组进行统计学分析。结果 对191份样本的9种呼吸道病毒进行检测,阳性样本86例,阳性率为45.0%;病毒感染率由高到低依次为:甲型流感病毒(FluA,26.7%,51/191)、乙型流感病毒(FluB,6.8%,13/191)、肠病毒/鼻病毒(E/R,3.7%,7/191)、冠状病毒(Cor,2.6%,5/191)、呼吸道合胞病毒(RSV,2.1%,4/191)、人偏肺病毒(hMPV,2.1%,4/191)、副流感病毒(PIV,1.0%,2/191),未检出腺病毒(AdV)和人博卡病毒(HBoV);病毒感染率在门诊患者与住院患者间、男性患者与女性患者间差异无统计学意义(P>0.05),但≤60岁组呼吸道病毒感染率显著高于>60岁组(χ2=12.264,P<0.05)。呼吸道病毒感染率各月份明显不同,以1月份感染率最高,占检出病毒总数的45.3%。结论 北京地区成人呼吸道感染病毒感染率在≤60岁组及1月份最高,病原体以FluA和FluB为主。

关键词: 病毒, 呼吸道感染, 成人, 流行病学, 北京

Abstract:

Objective To investigate the epidemiological characteristics of respiratory tract viruses among adult patients in Beijing. Methods Nasopharyngeal swabs were collected from outpatients and inpatients with acute respiratory tract infections in Beijing Hospital from April 2014 to March 2015. Liquid chip (xTAG RVP) was applied to detect 9 types of respiratory tract viruses(18 subtypes),and all results were statistically analyzed. Results A total of 191 samples were collected to monitor 9 types of viruses,86 samples were positive,and the positive rate was 45.0%. The positive rates from high to low were as follows:influenza A virus(FluA,26.7% ,51/191), influenza B virus(FluB,6.8%,13/191),enterovirus/rhinovirus(E/R,3.7%,7/191),coronaviridae(Cor,2.6%,5/191),respiratory syncytial virus(RSV,2.1%,4/191),human metapneumovirus(hMPV,2.1%,4/191) and parainfluenza virus(PIV,1.0%,2/191). Adenovirus(AdV) and human bocavirus(HBoV) were not detected. There was no statistical significance for positive rates between inpatient and outpatient groups, female and male groups(P>0.05). The positive rate of respiratory tract viruses in patients ≤60 years old was significantly higher than that in patients >60 years old(χ2=12.264,P<0.05). The positive rate of viruses had monthly variation,and it was the highest in January accounting for 45.3%. Conclusions In Beijing,the positive rate of respiratory tract viruses reaches the highest in patients ≤60 years old and in January. FluA and FluB are main pathogens.

Key words: Viruses, Respiratory tract infections, Adults, Epidemiology, Beijing

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