Hcy、MPV、hs-CRP及FIB对急性脑梗死诊断的价值

doi:10.3969/j.issn.1673-8640.2015.12.013

摘要/Abstract

摘要：

目的探讨同型半胱氨酸(Hcy)、平均血小板体积(MPV)、高敏C反应蛋白(hs-CRP)以及纤维蛋白原(FIB)检测在急性脑梗死中的诊断价值。方法选择急性脑梗死患者130例,按照神经缺损程度将患者分为轻度损伤组37例、中度损伤组62例以及重度损伤组31例,再选择70名健康受试者作为正常对照组,比较急性脑梗死各损伤程度组与正常对照组各指标水平变化情况以及各指标水平之间的相关性。结果急性脑梗死患者Hcy、MPV、hs-CRP及FIB水平均显著高于正常对照组(P<0.05);轻度损伤组、中度损伤组与重度损伤组患者Hcy、MPV、hs-CRP及FIB水平比较,差异均具有统计学意义(P<0.05),且损伤程度越重,其Hcy、MPV、hs-CRP及FIB水平越高;在Hcy、MPV、hs-CRP及FIB 4个指标间两两均呈显著正相关关系(P<0.05)。结论 Hcy、MPV、hs-CRP及FIB水平在急性脑梗死患者明显增高,且与病情程度密切相关,对了解患者病情的进展以及评估预后有着重要的价值。

关键词: 同型半胱氨酸, 平均血小板体积, 高敏C反应蛋白, 纤维蛋白原, 急性脑梗死

Abstract:

Objective To investigate the significance of homocysteine (Hcy), mean platelet volume (MPV), high-sensitivity C reactive protein (hs-CRP) and fibrinogen (FIB) in the diagnosis of acute cerebral infarction.Methods A total of 130 patients with acute cerebral infarction were enrolled. According to the degree of nerve defect, they were classified into mild group (37 cases), moderate group (62 cases) and severe group( 31 cases), and 70 healthy subjects were enrolled as control group. The correlations of each index between acute cerebral infarction group and control group were analyzed. Results Hcy, MPV, hs-CRP and FIB levels in acute cerebral infarction group were significantly higher than those in control group (P<0.05). Among mild, moderate and severe groups, Hcy, MPV, hs-CRP and FIB had statistical significance (P<0.05). The nerve defect degree was heavier, Hcy, MPV, hs-CRP and FIB levels were higher. Compared with 2 indices of Hcy, MPV, hs-CRP and FIB for each other, there was a significantly positive correlation (P<0.05). Conclusions Among patients with acute cerebral infarction, their Hcy, MPV, hs-CRP and FIB significantly increase, and are closely related the severity of disease. The determinations of Hcy, MPV, hs-CRP and FIB have important significance for the progress and prognosis.

Key words: Homocysteine, Mean platelet volume, High-sensitivity C reactive protein, Fibrinogen

中图分类号:

R446.11

诸越瑾, 张华, 姚洪锋. Hcy、MPV、hs-CRP及FIB对急性脑梗死诊断的价值[J]. 检验医学, 2015, 30(12): 1219-1221.

ZHU Yuejin, ZHANG Hua, YAO Hongfeng.. Significance of Hcy, MPV, hs-CRP and FIB for the diagnosis of acute cerebral infarction[J]. Laboratory Medicine, 2015, 30(12): 1219-1221.

图/表 3

参考文献 11

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组别	例数	Hcy(μmol/L)	MPV(fL)	hs-CRP(mg/L)	FIB(g/L)
急性脑梗死组	130	18.06±6.39	11.94±0.97	12.06±7.21	3.83±0.77
正常对照组	70	12.17±4.98	11.08±0.86	5.02±1.79	2.74±0.62
t值	-	6.692	6.217	8.029	10.194
P值	-	<0.05	<0.05	<0.05	<0.05

组别	例数	Hcy(μmol/L)	MPV(fL)	hs-CRP(mg/L)	FIB(g/L)
急性脑梗死组	130	18.06±6.39	11.94±0.97	12.06±7.21	3.83±0.77
正常对照组	70	12.17±4.98	11.08±0.86	5.02±1.79	2.74±0.62
t值	-	6.692	6.217	8.029	10.194
P值	-	<0.05	<0.05	<0.05	<0.05

组别	例数	Hcy(μmol/L)	MPV(fL)	hsCRP(mg/L)	FIB(g/L)
轻度损伤组	37	15.29±5.68	9.88±1.31	7.22±5.82	3.05±0.67
中度损伤组	62	19.16±7.83^*	11.67±0.84^*	12.35±7.94^*	3.48±0.69^*
重度损伤组	31	21.27±6.92^*#	12.94±0.97^*#	14.08±6.86^*#	4.62±0.84^*#
F值	-	4.511	7.059	9.561	5.976
P值	-	<0.05	<0.05	<0.05	<0.05

组别	例数	Hcy(μmol/L)	MPV(fL)	hsCRP(mg/L)	FIB(g/L)
轻度损伤组	37	15.29±5.68	9.88±1.31	7.22±5.82	3.05±0.67
中度损伤组	62	19.16±7.83^*	11.67±0.84^*	12.35±7.94^*	3.48±0.69^*
重度损伤组	31	21.27±6.92^*#	12.94±0.97^*#	14.08±6.86^*#	4.62±0.84^*#
F值	-	4.511	7.059	9.561	5.976
P值	-	<0.05	<0.05	<0.05	<0.05

指标	Hcy	MPV	hsCRP	FIB
Hcy	-	0.475^*	0.638^*	0.593^*
MPV	0.475^*	-	0.448^*	0.496^*
hs-CRP	0.638^*	0.448^*	-	0.674^*
FIB	0.593^*	0.496^*	0.674^*	-