淋巴细胞活化基因3的免疫抑制功能及其在慢性病毒感染性疾病中的作用

doi:10.3969/j.issn.1673-8640.2015.03.026

检验医学 ›› 2015, Vol. 30 ›› Issue (3): 298-302.DOI: 10.3969/j.issn.1673-8640.2015.03.026

淋巴细胞活化基因3的免疫抑制功能及其在慢性病毒感染性疾病中的作用

马晨芸综述¹, 陆志成², 沈茜审校¹

1. 第二军医大学附属长海医院实验诊断科,上海 200433
2. 上海市第七人民医院医学检验科,上海 200137

收稿日期:2014-08-22 出版日期:2015-03-30 发布日期:2015-04-16
作者简介:null
作者简介:马晨芸,女,1982年生,学士,主管技师,主要从事临床检验工作。
基金资助:
浦东新区卫生系统优秀青年医学人才培养计划(PWRq2012-35);上海市卫生和计划生育委员会科研课题计划(201440353)

The immunosuppression of lymphocyte activation gene 3 and its effects in chronic viral infection

MA Chenyun¹, LU Zhicheng², SHEN Qian¹

1. Department of Clinical Laboratory, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
2. Department of Medical Laboratory, Shanghai Seventh People's Hospital, Shanghai 200137,China

Received:2014-08-22 Online:2015-03-30 Published:2015-04-16

摘要/Abstract

摘要：

T细胞耗竭是机体抗病毒的T细胞应答不能有效地控制病毒复制和清除病毒的主要机制。淋巴细胞活化基因3(LAG-3)是重要的免疫共抑制分子,主要表达在活化的T细胞表面,与CD4分子结构相似,且能与主要组织相容性复合物(MHC)-Ⅱ类分子高度结合,负向调节T淋巴细胞的增殖和功能,维持其内环境的稳定。慢性病毒感染性疾病中,LAG-3高表达于病毒特异性T细胞表面,引起T细胞的耗竭。

关键词: 淋巴细胞活化基因3, T细胞, 慢性病毒感染, 耗竭

Abstract:

T cell depletion is the main mechanism that T cell responses can not effectively control viral replication and eliminate virus. Lymphocyte activation gene 3 (LAG-3) is a vital immune co-inhibitory molecule which is similar to CD4 molecule structure and mainly expresses on activated T cells. LAG-3 can be combined with major histocompability complex (MHC)-Ⅱ molecules, and it's also a negative regulator of T lymphocyte's proliferation and function for maintaining the homeostasis. LAG-3 highly expresses on the surface of virus-specific T cells causing T cell depletion in chronic viral infection.

Key words: Lymphocyte activation gene 3, T cell, Chronic viral infection, Depletion

中图分类号:

R446.62

马晨芸综述, 陆志成, 沈茜审校. 淋巴细胞活化基因3的免疫抑制功能及其在慢性病毒感染性疾病中的作用[J]. 检验医学, 2015, 30(3): 298-302.

MA Chenyun, LU Zhicheng, SHEN Qian. The immunosuppression of lymphocyte activation gene 3 and its effects in chronic viral infection[J]. Laboratory Medicine, 2015, 30(3): 298-302.

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淋巴细胞活化基因3的免疫抑制功能及其在慢性病毒感染性疾病中的作用

The immunosuppression of lymphocyte activation gene 3 and its effects in chronic viral infection

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