Serum amyloid A and C-reactive protein combined determination for diagnosis of bacterial infection in neonates

doi:10.3969/j.issn.1673-8640.2016.03.005

Abstract

Abstract:

Objective To study the significance of serum amyloid A（SAA）,C-reactive protein （CRP） and white blood cell count determinations for diagnosis of bacterial infection in neonates. Methods SAA,CRP and white blood cell count were determined in 80 neonates with bacterial infection and 58 healthy neonates （non-bacterial infection group）,and the results were analyzed. Results The concentrations of SAA and CRP in infection group [（67.3±38.4）and （19.2±11.2） mg/L] were significantly higher than those in non-bacterial infection group [（8.7±2.1）and （5.6±2.5） mg/L]（P<0.05）. The white blood cell count was >15.00×10⁹/L in 64 neonates of 80 cases of infection group（80%）, which was higher than that in non-bacterial infection group [24 cases （41%）]. Conclusions SAA and CRP could be used as important markers for monitoring bacterial infection in neonates,and SAA is more sensitive than CRP. The combined determination of SAA and CRP could improve the determination rate of bacterial infection,which provides an experimental reference for early diagnosis and monitoring of bacterial infection.

Key words: Serum amyloid A, C-reactive protein, Neonatal bacterial infection

CLC Number:

R446.1

SHEN Weihong, YUE Chaoyan, SUN Zhendong, YING Chunmei. Serum amyloid A and C-reactive protein combined determination for diagnosis of bacterial infection in neonates[J]. Laboratory Medicine, 2016, 31(3): 173-175.

Figures/Tables 2

References 15

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组别	例数	白细胞总数（×10⁹/L）
组别	例数	9~15	>15~30	>30~40
新生儿细菌感染组	80	16（20）	52（65）	12（15）
非感染组	58	34（59）	21（36）	3（5）

组别	例数	白细胞总数（×10⁹/L）
组别	例数	9~15	>15~30	>30~40
新生儿细菌感染组	80	16（20）	52（65）	12（15）
非感染组	58	34（59）	21（36）	3（5）

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