Changes of serum diamine oxidase,D-lactic acid and endotoxin in patients with schizophrenia

doi:10.3969/j.issn.1673-8640.2021.010.010

Abstract

Abstract:

Objective To investigate the roles of serum diamine oxidase,D-lactic acid and endotoxin in the assessment of intestinal barrier injury in patients with schizophrenia. Methods A total of 296 schizophrenia patients and 99 healthy subjects were enrolled,and serum diamine oxidase,D-lactic acid and endotoxin levels were determined. The 296 schizophrenia patients were classified according to ages（≤51-year-old and >51-year-old groups） and sex. Results The levels of serum diamine oxidase,D-lactic acid and endotoxin in schizophrenia group were higher than those in healthy control group（P<0.05）. There was no statistical significance in serum diamine oxidase,D-lactic acid and endotoxin between ≤51-year-old and >51-year-old groups and between males and females（P>0.05）. Conclusions Serum diamine oxidase,D-lactic acid and endotoxin can be used to assess the intestinal barrier function in patients with schizophrenia.

Key words: Diamine oxidase, D-lactic acid, Endotoxin, Schizophrenia

CLC Number:

Q554

JIN Weifeng, LI Ping, CHEN Shuzi, SUN Jiaqi, FANG Wei, LI Dan, ZHU Liping, ZHU Lili, LIN Ping. Changes of serum diamine oxidase,D-lactic acid and endotoxin in patients with schizophrenia[J]. Laboratory Medicine, 2021, 36(10): 1039-1041.

Figures/Tables 3

References 17

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组别	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
精神分裂症组	296	18.71（13.24~25.44）	29.40（23.88~38.67）	18.76（16.09~23.24）
正常对照组	99	7.70（5.00~11.23）	9.46（5.33~13.10）	5.68（1.78~9.83）
U值		4 209.5	1 425.0	1 309.0
P值		0.000	0.000	0.000

组别	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
精神分裂症组	296	18.71（13.24~25.44）	29.40（23.88~38.67）	18.76（16.09~23.24）
正常对照组	99	7.70（5.00~11.23）	9.46（5.33~13.10）	5.68（1.78~9.83）
U值		4 209.5	1 425.0	1 309.0
P值		0.000	0.000	0.000

年龄	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
≤51岁	150	18.05（11.76~24.71）	28.55（22.75~37.08）	18.45（15.99~23.25）
>51岁	146	19.06（13.80~26.45）	30.42（24.10~40.05）	19.14（16.31~23.27）
U值		9 800.5	10 243.5	10 398.5
P值		0.118	0.337	0.454

年龄	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
≤51岁	150	18.05（11.76~24.71）	28.55（22.75~37.08）	18.45（15.99~23.25）
>51岁	146	19.06（13.80~26.45）	30.42（24.10~40.05）	19.14（16.31~23.27）
U值		9 800.5	10 243.5	10 398.5
P值		0.118	0.337	0.454

性别	例数	二胺氧化酶/（U/L）	D-乳酸/（mg/L）	内毒素/（U/L）
男性	160	18.71（13.22~26.20）	29.60（24.37~37.51）	18.51（16.48~22.99）
女性	136	18.55（13.33~25.09）	29.20（22.72~39.44）	19.05（15.48~23.57）
U值		10 480.0	10 859.5	10 762.0
P值		0.586	0.978	0.872