Abstract:

Objective To investigate the correlation of serum ten-eleven translocation（TET2），oxidized low-density lipoprotein （ox-LDL），clusterin（CLU）with ventricular remodeling and major adverse cardiovascular events （MACE） in patients with acute myocardial infarction （AMI）after ventricular remodeling and percutaneous coronary intervention （PCI）. Methods A total of 97 patients with AMI （AMI group） and 97 healthy subjects （healthy control group） were enrolled from the Affiliated Hospital of Chengde Medical College from May 2020 to May 2022. The clinical data of all subjects were collected，and serum TET2，ox-LDL，CLU levels and ventricular remodeling indexes [left ventricular ejection fraction （LVEF），left ventricular end-systolic volume （LVESV），left ventricular end-diastolic diameter （LVEDD），left ventricular mass index （LVMI）] were determined before PCI. All the patients underwent PCI and were followed up for 1 year. They were classified into MACE group and non-MACE group. Pearson correlation analysis was used to evaluate the correlation among the indexes. Receiver operating characteristic （ROC） curve was used to evaluate the efficacy of various indexes in determining MACE in AMI patients. Results Compared with healthy control group，serum ox-LDL，CLU，LVEDD，LVESV and LVMI in AMI group were increased （P<0.001），and serum TET2 and LVEF were decreased （P<0.001）. Serum ox-LDL and CLU in AMI group were positively correlated with LVEDD，LVESV and LVMI （P<0.001），and they were negatively correlated with LVEF （P<0.001）. Serum TET2 was negatively correlated with LVEDD，LVESV and LVMI （P<0.001），and it was positively correlated with LVEF （P<0.001）. Compared with non-MACE group，serum ox-LDL and CLU in MACE group were increased （P<0.05），and serum TET2 level was decreased （P<0.001）. The areas under curves（AUC） of serum TET2，ox-LDL and CLU single and combined determinations for MACE in AMI patients were 0.689，0.657，0.664 and 0.839，respectively. Conclusions Serum TET2，ox-LDL and CLU are related to ventricular remodeling and MACE in AMI patients，and the combined determination of TET2，ox-LDL and CLU has a good predictive value for MACE in AMI patients after PCI.

Key words: Ten-eleven translocation 2, Oxidized low-density lipoprotein, Clusterin, Ventricular remodeling, Major adverse cardiovascular event, Acute myocardial infarction