Clinical value and prospect of peripheral blood immune indexes in cancer patients

doi:10.3969/j.issn.1673-8640.2024.04.001

Abstract

Abstract:

Immune microenvironment formed by local immune reaction and inflammatory responses plays a role in tumorigenesis，development and metastasis. It consists of tumor cells，immune cells（neutrophils，macrophages and lymphocytes） and the cytokines and chemokines they produce. These components interact with each other to form a complex network that affects the body's immune status. Peripheral blood immune indexes can be a valuable reference for the auxiliary diagnosis，prognosis and efficacy prediction of cancer patients，particularly in evaluating immunotherapy，which has a potential for clinical application. However，interpreting test results can be challenging due to the significant differences in individual immune status among cancer patients. This review focuses on the clinical value and potential applications of peripheral blood immune indexes in cancer patients.

Key words: Immune cell grouping, Cytokine, Tumor-associated autoantibody, Soluble immune checkpoint, Malignancy

CLC Number:

R446.1

ZHANG Han, GUO Lin, LU Renquan, CHEN Fuxiang. Clinical value and prospect of peripheral blood immune indexes in cancer patients[J]. Laboratory Medicine, 2024, 39(4): 311-316.

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