Abstract:

Objective To study the relationship between uridine diphosphate-glucuronosyl-transferase 1A1（UGT1A1） gene polymorphism and pregnancy complications and adverse pregnancy outcomes in patients with gestational hypothyroidism in Shenzhen Bao'an area. Methods Totally，160 patients with gestational hypothyroidism in Shenzhen Bao'an Shiyan People's Hospital from April 2019 to April 2021 were enrolled as study group. Another 160 pregnant females with normal thyroid function were enrolled as control group. UGT1A1 gene polymorphism was determined. The pregnancy complications（hypertension，diabetes and intrahepatic cholestasis） and adverse pregnancy outcomes（preterm birth，fetal distress and neonatal asphyxia） in different UGT1A1 genotypes were compared. Results The proportion of UGT1A1 GG genotype in study group was 16.25%，which was lower than that in control group（51.25%）（P<0.001），while the proportions of GA and AA genotypes were 42.50% and 41.25%，which were higher than those in control group（23.75% and 25.00%，respectively）（P<0.001，P<0.05）. In study group，the incidence rates of hypertension，diabetes and intrahepatic cholestasis in patients with AA genotype were 18.18%，21.21% and 12.12%，respectively，which were higher than those with GG genotype（0.00%，3.85% and 0.00%，respectively） and GA genotype（2.94%，4.41% and 0.00%，respectively）（P<0.05）. In study group，the total incidence rate of adverse pregnancy outcomes in AA genotype was 21.21%，which was higher than those in GG genotype（0.00%） and GA genotype（5.88%）（P<0.05）. Conclusions UGT1A1 genotypes of patients with gestational hypothyroidism in Shenzhen Bao'an area are mainly GA and AA，among which AA genotype patients have high risk of pregnancy complications and adverse pregnancy outcomes.

Key words: Uridine diphosphate-glucuronosyl-transferase 1A1, Gene polymorphism, Hypothyroidism, Pregnancy complication, Shenzhen