Laboratory Medicine ›› 2023, Vol. 38 ›› Issue (6): 510-517.DOI: 10.3969/j.issn.1673-8640.2023.06.002
Previous Articles Next Articles
YANG Qiong, XU Fen, LIN Yahui()
Received:
2022-06-20
Revised:
2023-01-09
Online:
2023-06-30
Published:
2023-08-22
CLC Number:
YANG Qiong, XU Fen, LIN Yahui. Clinical application of cardiac troponin determination in pediatric cardiac involvement related diseases[J]. Laboratory Medicine, 2023, 38(6): 510-517.
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2023.06.002
[1] | 张乾忠, 祝华. 儿童心肌损伤及心肌炎诊治中的几个临床热点问题[J]. 中国小儿急救医学, 2018, 25(9):641-646. |
[2] | 李铁耕. 高敏心肌肌钙蛋白T在新生儿疾病中的临床应用进展[J]. 中国当代儿科杂志, 2019, 21(9):936-941. |
[3] |
PARK K C, GAZE D C, COLLINSON P O, et al. Cardiac troponins:from myocardial infarction to chronic disease[J]. Cardiovasc Res, 2017, 113(14):1708-1718.
DOI URL |
[4] | 中国医师协会检验医师分会心血管专家委员会. 心肌肌钙蛋白实验室检测与临床应用中国专家共识[J]. 中华医学杂志, 2021, 101(37):2947-2961. |
[5] | LAZAR D R, LAZAR F L, HOMORODEAN C, et al. High-sensitivity troponin:a review on characteristics,assessment,and clinical implications[J]. Dis Markers, 2022, 2022:9713326. |
[6] |
LAM E, HIGGINS V, ZHANG L, et al. Normative values of high-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in children and adolescents:a study from the CALIPER cohort[J]. J Appl Lab Med, 2021, 6(2):344-353.
DOI URL |
[7] |
BOHN M K, HIGGINS V, KAVSAK P, et al. High-sensitivity generation 5 cardiac troponin T sex- and age-specific 99th percentiles in the CALIPER cohort of healthy children and adolescents[J]. Clin Chem, 2019, 65(4):589-591.
DOI PMID |
[8] |
KAVSAK P A, REZANPOUR A, CHEN Y, et al. Assessment of the 99th or 97.5th percentile for cardiac troponin I in a healthy pediatric cohort[J]. Clin Chem, 2014, 60(12):1574-1576.
DOI PMID |
[9] |
GUO Q, YANG D, ZHOU Y, et al. Establishment of the reference interval for high-sensitivity cardiac troponin T in healthy children of Chongqing Nan'an district[J]. Scand J Clin Lab Invest, 2021, 81(7):579-584.
DOI URL |
[10] | 李青青. 佛山地区婴儿血清心肌肌钙蛋白I参考区间的建立及意义[J]. 检验医学与临床, 2021, 18(21):3191-3193. |
[11] |
BOHN M K, STEELE S, HALL A, et al. Cardiac biomarkers in pediatrics:an undervalued resource[J]. Clin Chem, 2021, 67(7):947-958.
DOI URL |
[12] |
DIONNE A, KHEIR J N, SLEEPER L A, et al. Value of troponin testing for detection of heart disease in previously healthy children[J]. J Am Heart Assoc, 2020, 9(4):e012897.
DOI URL |
[13] |
YOLDA T, ÖRÜN U A. What is the significance of elevated troponin I in children and adolescents? a diagnostic approach[J]. Pediatr Cardiol, 2019, 40(8):1638-1644.
DOI PMID |
[14] | 李奇蕊, 甄珍, 那嘉, 等. 儿童左冠状动脉异常起源于右冠状窦伴动脉间行程四例分析[J]. 中华儿科杂志, 2020, 58(2):113-117. |
[15] | 李赫, 程佶, 尹晶, 等. 学龄儿童川崎病急性期合并心肌梗死一例报告[J]. 天津医药, 2018, 46(4):429-431. |
[16] | 李盈禄, 张兆奎, 李寿山, 等. 左室黏液瘤致儿童急性心肌梗死一例[J]. 中华儿科杂志, 2007, 45(6):473. |
[17] | 王树水, 张智伟, 曾少颖, 等. 儿童白塞病合并急性心肌梗死一例[J]. 中华风湿病学杂志, 2006, 10(6):382-384. |
[18] | 杨震. 儿童急性心肌梗死1例[J]. 河北医药, 2005, 27(1):60. |
[19] |
LANE J R, BEN-SHACHAR G. Myocardial infarction in healthy adolescents[J]. Pediatrics, 2007, 120(4):e938- e943.
DOI PMID |
[20] | 何兵, 江钟炎, 庹虎. 儿童心肌炎诊断建议(2018年版)解读[J]. 中华儿科杂志, 2019, 57(2):90-92. |
[21] |
CLERICO A, AIMO A, CANTINOTTI M. High-sensitivity cardiac troponins in pediatric population[J]. Clin Chem Lab Med, 2021, 60(1):18-32.
DOI PMID |
[22] |
PRICE S, BODYS A, CELISKA A, et al. The value of chosen diagnostic tools in evaluating myocarditis in children and adolescents[J]. Pediatr Pol, 2018, 93(5):389-395.
DOI URL |
[23] |
SUTHAR D, DODD D A, GODOWN J. Identifying non-invasive tools to distinguish acute myocarditis from dilated cardiomyopathy in children[J]. Pediatr Cardiol, 2018, 39(6):1134-1138.
DOI PMID |
[24] |
SOONGSWANG J, DURONGPISITKUL K, NANA A, et al. Cardiac troponin T:a marker in the diagnosis of acute myocarditis in children[J]. Pediatr Cardiol, 2005, 26(1):45-49.
DOI URL |
[25] |
EISENBERG M A, GREEN-HOPKINS I, ALEXANDER M E, et al. Cardiac troponin T as a screening test for myocarditis in children[J]. Pediatr Emerg Care, 2012, 28(11):1173-1178.
DOI PMID |
[26] |
HOWARD A, HASAN A, BROWNLEE J, et al. Pediatric myocarditis protocol:an algorithm for early identification and management with retrospective analysis for validation[J]. Pediatr Cardiol, 2020, 41(2):316-326.
DOI |
[27] |
RODRIGUEZ-GONZALEZ M, SANCHEZ-CODEZ M I, LUBIAN-GUTIERREZ M, et al. Clinical presentation and early predictors for poor outcomes in pediatric myocarditis:a retrospective study[J]. World J Clin Cases, 2019, 7(5):548-561.
DOI URL |
[28] |
BUTTO A, ROSSANO J W, NANDI D, et al. Elevated troponin in the first 72 h of hospitalization for pediatric viral myocarditis is associated with ECMO:an analysis of the PHIS+ database[J]. Pediatr Cardiol, 2018, 39(6):1139-1143.
DOI |
[29] | 胡盛寿. 《先天性心脏病外科治疗中国专家共识》述评[J]. 中国胸心血管外科临床杂志, 2021, 28(1):1-3. |
[30] |
SUGIMOTO M, KUWATA S, KURISHIMA C, et al. Cardiac biomarkers in children with congenital heart disease[J]. World J Pediatr, 2015, 11(4):309-315.
DOI PMID |
[31] |
KOTBY A A, ABD AL AZIZ M M, HUSSEINY A H, et al. Detection of early myocardial injury in children with ventricular septal defect using cardiac troponin I and two-dimensional speckle tracking echocardiography[J]. Pediatr Cardiol, 2020, 41(8):1548-1558.
DOI |
[32] | HAFEZ M O, MORSY S M, MAHFOZ R A, et al. Myocardial injury in children with unoperated congenital heart diseases[J]. Cardiol Res Pract, 2015, 2015:104818. |
[33] |
KAYALI S, ERTUGRUL I, YOLDAS T, et al. Sensitive cardiac troponins:could they be new biomarkers in pediatric pulmonary hypertension due to congenital heart disease?[J]. Pediatr Cardiol, 2018, 39(4):718-725.
DOI |
[34] |
SCHUURING M J, VAN RIEL A C, VIS J C, et al. High-sensitivity troponin T is associated with poor outcome in adults with pulmonary arterial hypertension due to congenital heart disease[J]. Congenit Heart Dis, 2013, 8(6):520-526.
DOI PMID |
[35] |
SU J A, KUMAR S R, MAHMOUD H, et al. Postoperative serum troponin trends in infants undergoing cardiac surgery[J]. Semin Thorac Cardiovasc Surg, 2019, 31(2):244-251.
DOI PMID |
[36] |
KOJIMA T, TODA K, OYANAGI T, et al. Early assessment of cardiac troponin I predicts the postoperative cardiac status and clinical course after congenital heart disease surgery[J]. Heart Vessels, 2020, 35(3):417-421.
DOI PMID |
[37] |
GIORDANO R, CANTINOTTI M, ARCIERI L, et al. Arterial switch operation and plasma biomarkers:analysis and correlation with early postoperative outcomes[J]. Pediatr Cardiol, 2017, 38(5):1071-1076.
DOI URL |
[38] |
ASRANI P, ALY A M, JIWANI A K, et al. High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus[J]. J Perinatol, 2018, 38(11):1483-1489.
DOI PMID |
[39] |
SATO Y Z, MOLKARA D P, DANIELS L B, et al. Cardiovascular biomarkers in acute Kawasaki disease[J]. Int J Cardiol, 2013, 164(1):58-63.
DOI PMID |
[40] | 易岂建, 钱永如, 张渝美, 等. 急性期川崎病儿血清心肌肌钙蛋白Ⅰ变化及临床意义[J]. 实用儿科临床杂志, 2001, 16(1):14-15. |
[41] | 王潇. 血清缺血修饰白蛋白、淀粉样蛋白A及肌钙蛋白Ⅰ对川崎病患儿合并冠状动脉损伤的诊断价值[J]. 中国临床医生杂志, 2020, 48(11):1366-1369. |
[42] |
XUE M, WANG J. Utility of color Doppler echocardiography combined with clinical markers in diagnosis and prediction of prognosis of coronary artery lesions in Kawasaki disease[J]. Exp Ther Med, 2020, 19(4):2597-2603.
DOI PMID |
[43] | 中华医学会儿科学分会心血管学组, 中国医师协会心血管内科医师分会儿童心血管专业委员会, 中华儿科杂志编辑委员会. 儿童心力衰竭诊断和治疗建议(2020年修订版)[J]. 中华儿科杂志, 2021, 59(2):84-94. |
[44] |
EL-AMROUSY D, HASSAN S, HODEIB H. Prognostic value of homocysteine and highly sensitive cardiac troponin T in children with acute heart failure[J]. J Saudi Heart Assoc, 2018, 30(3):198-204.
DOI URL |
[45] |
IMAZIO M, COOPER L T. Management of myopericarditis[J]. Expert Rev Cardiovasc Ther, 2013, 11(2):193-201.
DOI PMID |
[46] |
LIESEMER K, CASPER T C, KORGENSKI K, et al. Use and misuse of serum troponin assays in pediatric practice[J]. Am J Cardiol, 2012, 110(2):284-289.
DOI PMID |
[47] | 程晔, 应佳云, 刘彦婷, 等. 《2020拯救脓毒症运动国际指南:儿童脓毒性休克和脓毒症相关器官功能障碍管理》解读[J]. 中国小儿急救医学, 2020, 27(4):241-248. |
[48] |
LAUTZ A J, WONG H R, RYAN T D, et al. Myocardial dysfunction is independently associated with mortality in pediatric septic shock[J]. Crit Care Explor, 2020, 2(10):e0231.
DOI PMID |
[49] |
ZHANG Y, LUO Y, NIJIATIJIANG G, et al. Correlations of changes in brain natriuretic peptide(BNP)and cardiac troponin I(cTnI)with levels of C-reactive protein(CRP)and TNF-α in pediatric patients with sepsis[J]. Med Sci Monit, 2019, 25:2561-2566.
DOI URL |
[50] |
RAJ S, KILLINGER J S, GONZALEZ J A, et al. Myocardial dysfunction in pediatric septic shock[J]. J Pediatr, 2014, 164(1):72-77.e2.
DOI URL |
[51] |
FENTON K E, SABLE C A, BELL M J, et al. Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock[J]. Pediatr Crit Care Med, 2004, 5(6):533-538.
DOI URL |
[52] |
GUYTHER J, CANTWELL L. Big tests in little people[J]. Emerg Med Clin North Am, 2021, 39(3):467-478.
DOI URL |
[53] | 中华人民共和国国家健康委员会, 国家中医药局. 儿童社区获得性肺炎诊疗规范(2019年版)[J]. 中华临床感染病杂志, 2019, 12(1):6-13. |
[54] |
DENG M H, LIN C W, SUN Y N, et al. Role of E-selectin for diagnosing myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia[J]. Ann Clin Biochem, 2017, 54(1):49-54.
DOI URL |
[55] | 王颖, 严小光, 姚洪宇. 支气管肺炎住院患儿心肌酶和肌钙蛋白Ⅰ水平变化[J]. 中国妇幼保健, 2021, 36(9):2077-2079. |
[56] | HAN F, GAO J, GAI J. Detection of myocardial enzymes,cardiac troponin T and hepatic and renal function in the diagnosis and treatment of severe pneumonia in children[J]. Pak J Med Sci, 2018, 34(5):1257-1261. |
[57] | PEREIRA M F B, LITVINOV N, FARHAT S C L, et al. Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome[J]. Clinics(Sao Paulo), 2020, 75:e2209. |
[58] |
GÜLLÜ U U, GÜNGÖR, PEK S, et al. Predictive value of cardiac markers in the prognosis of COVID-19 in children[J]. Am J Emerg Med, 2021, 48:307-311.
DOI PMID |
[59] |
VALVERDE I, SINGH Y, SANCHEZ-DE-TOLEDO J, et al. Acute cardiovascular manifestations in 286 children with multisystem inflammatory syndrome associated with COVID-19 infection in Europe[J]. Circulation, 2021, 143(1):21-32.
DOI PMID |
[60] |
TORAIH E A, HUSSEIN M H, ELSHAZLI R M, et al. Multisystem inflammatory syndrome in pediatric COVID-19 patients:a meta-analysis[J]. World J Pediatr, 2021, 17(2):141-151.
DOI |
[61] |
REFFO E, STRITONI V, DI SALVO G. Inflammatory syndrome in children associated with COVID-19 complicated by acute myocardial infarction[J]. Eur Heart J, 2021, 42(21):2136.
DOI URL |
[62] | 刘春艳, 龙佩, 朱薇. 血清肌钙蛋白I、肌酸激酶同工酶及乳酸转氨酶联合检测对小儿手足口病诊断意义探讨[J]. 实用医院临床杂志, 2019, 16(1):11-13. |
[63] | 高西阳. 血清cTnⅠ、CK-MB、乳酸脱氢酶在手足口病患儿中的表达及意义分析[J]. 吉林医学, 2021, 42(10):2489-2490. |
[64] | 刘颖, 田永波, 陈富菊, 等. 心肌酶谱和高敏肌钙蛋白T在小儿手足口病并发心肌损伤诊断中的应用[J]. 中西医结合心血管病电子杂志, 2019, 7(19):87. |
[65] |
LIU J, QI J. Prevalence and management of severe hand,foot,and mouth disease in Xiangyang,China,from 2008 to 2013[J]. Front Pediatr, 2020, 8:323.
DOI URL |
[66] | JIANG L, LI Y, ZHANG Z, et al. Use of high-sensitivity cardiac troponin I levels for early diagnosis of myocardial injury after neonatal asphyxia[J]. J Int Med Re, 2019, 47(7):3234-3242. |
[67] |
YILDIRIM A, OZGEN F, UCAR B, et al. The diagnostic value of troponin T level in the determination of cardiac damage in perinatal asphyxia newborns[J]. Fetal Pediatr Pathol, 2016, 35(1):29-36.
DOI PMID |
[68] |
HELMER C, SKRANES J H, LIESTØL K, et al. Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels[J]. Acta Paediatr, 2015, 104(9):e378- e383.
DOI URL |
[69] |
SWEETMAN D U, KELLY L, HURLEY T, et al. Troponin T correlates with MRI results in neonatal encephalopathy[J]. Acta Paediatr, 2020, 109(11):2266-2270.
DOI URL |
[70] |
CLARK S J, NEWLAND P, YOXALL C W, et al. Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome[J]. Eur J Pediatr, 2006, 165(2):87-93.
PMID |
[71] |
PUDIL R, MUELLER C, ELUTKIEN J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies:a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology[J]. Eur J Heart Fail, 2020, 22(11):1966-1983.
DOI URL |
[72] |
MCDONAGH T A, METRA M, ADAMO M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure[J]. Eur Heart J, 2021, 42(36):3599-3726.
DOI URL |
[73] |
NATHAN P C, AMIR E, ABDEL-QADIR H. Cardiac outcomes in survivors of pediatric and adult cancers[J]. Can J Cardiol, 2016, 32(7):871-880.
DOI PMID |
[74] |
KUNARAJAH K, HENNIG S, NORRIS R L G, et al. Population pharmacokinetic modelling of doxorubicin and doxorubicinol in children with cancer:is there a relationship with cardiac troponin profiles?[J]. Cancer Chemother Pharmacol, 2017, 80(1):15-25.
DOI URL |
[75] |
RADU L E, GHIORGHIU I, OPRESCU A, et al. Cardiotoxicity evaluation in pediatric patients with acute lymphoblastic leukemia - results of prospective study[J]. Med Ultrason, 2019, 21(4):449-455.
DOI PMID |
[76] |
MICHEL L, MINCU R I, MROTZEK S M, et al. Cardiac biomarkers for the detection of cardiotoxicity in childhood cancer-a meta-analysis[J]. ESC Heart Fail, 2020, 7(2):423-433.
DOI PMID |
[77] |
CHONG D, CHUA Y T, CHONG S L, et al. What raises troponins in the paediatric population?[J]. Pediatr Cardiol, 2018, 39(8):1530-1534.
DOI PMID |
[78] |
SANGHA G S, PEPELASSIS D, BUFFO-SEQUEIRA I, et al. Serum troponin-I as an indicator of clinically significant myocardial injury in paediatric trauma patients[J]. Injury, 2012, 43(12):2046-2050.
DOI PMID |
[79] |
BRAUN C K, SCHAFFER A, WEBER B, et al. The prognostic value of troponin in pediatric polytrauma[J]. Front Pediatr, 2019, 7:477.
DOI PMID |
[80] |
GOSAVI S, TYROCH A H, MUKHERJEE D. Cardiac trauma[J]. Angiology, 2016, 67(10):896-901.
DOI PMID |
[81] |
GENRICH I, O'MARA S K, SULO S. Using a new evidence-based trauma protocol to improve detection and reduce costs in patients with blunt cardiac injury[J]. J Trauma Nurs, 2015, 22(1):28-34.
DOI PMID |
[82] |
WEBER B, LACKNER I, BRAUN C K, et al. Laboratory markers in the management of pediatric polytrauma:current role and areas of future research[J]. Front Pediatr, 2021, 9:622753.
DOI URL |
[83] |
OZYURT A, KARPUZ D, YUCEL A, et al. Effects of acute carbon monoxide poisoning on ECG and echocardiographic parameters in children[J]. Cardiovasc Toxicol, 2017, 17(3):326-334.
DOI PMID |
[84] |
TEKSAM O, GUMUS P, BAYRAKCI B, et al. Acute cardiac effects of carbon monoxide poisoning in children[J]. Eur J Emerg Med, 2010, 17(4):192-196.
DOI PMID |
[85] | AKCAN YILDIZ L, GULTEKINGIL A, KESICI S, et al. Predictors of severe clinical course in children with carbon monoxide poisoning[J]. Pediatr Emerg Care, 2021, 37(6):308-311. |
[1] | JI Ran, LI Na, ZHANG Yu, LIU Yiming. Changes of serum FoxO3a and Cav-1 levels in children with craniocerebral trauma and their clinical significance [J]. Laboratory Medicine, 2024, 39(8): 728-732. |
[2] | DAI Yao, LI Jiahui, XU Xiuhong. Prognosis evaluation model of children with Mycoplasma pneumoniae pneumonia based on MP DNA and peripheral blood inflammation indicators [J]. Laboratory Medicine, 2024, 39(6): 568-572. |
[3] | JIANG Jingjing, GU Ping, WANG Chengyun, ZHANG Fan, SHEN Huiying, PAN Qiuhui, WANG Jing. Changes and clinical significance of procalcitonin and coagulation function indicators in children with sepsis [J]. Laboratory Medicine, 2024, 39(6): 573-577. |
[4] | YAN Jianghong, WANG Le, MA Lin, YANG Shuo, GUO Weiwei, ZHAO Mengchuan, LIU Zehao, ZHAI Xiaoying. Clinical characteristics of acute lymphoblastic leukemia children infected with Epstein-Barr virus [J]. Laboratory Medicine, 2024, 39(6): 583-586. |
[5] | LIU Ruishan, LONG Fengming, ZOU Chengli. Role of serum exosomal miR-93-5p determination in children with bronchial asthma [J]. Laboratory Medicine, 2024, 39(5): 449-453. |
[6] | ZHANG Na, LI Jing, YAN Xiaojing, ZHANG Lan, LIU Weixiao. Roles of IP-10 and MCP-1 in cerebrospinal fluid of children with viral encephalitis [J]. Laboratory Medicine, 2024, 39(5): 454-457. |
[7] | YANG Jing, LIU Huapeng, LIU Ni. Role of serum MyD88 and TRAF-6 combined determination in diagnosis and prognosis of severe acute respiratory tract infection in children [J]. Laboratory Medicine, 2024, 39(3): 237-242. |
[8] | CHEN Huan, DONG Fang, LÜ Zhiyong, ZHEN Jinghui, CHEN Mei, SU Jianrong. Serotypes and drug resistance of invasive Streptococcus agalactiae in children [J]. Laboratory Medicine, 2024, 39(3): 260-264. |
[9] | DONG Mingying, TAO Bingtong, LI Enyao. Role of plasma leptin determination in nutritional status and bone mineral density in preschool children [J]. Laboratory Medicine, 2024, 39(3): 272-276. |
[10] | JING Mengxia, YU Yongguo. Clinical application of different molecular detection techniques in children's rare genetic diseases [J]. Laboratory Medicine, 2024, 39(2): 103-106. |
[11] | ZHOU Yingqin, XIAO Yuan, MENG Jun. Roles of fecal calprotectin and other inflammatory indicators in children with Crohn's disease [J]. Laboratory Medicine, 2024, 39(2): 161-165. |
[12] | XIE Xin, SHI Lihuan, FAN Pengkai, CHEN Jing. Relation of core-binding factor acute myeloid leukemia associated with KIT mutation in children and clinical characteristics and prognosis [J]. Laboratory Medicine, 2024, 39(10): 1010-1014. |
[13] | WANG Huiying, TANG Yu, DONG Lili, WANG Jing. Role of Mycoplasma pneumoniae RNA determination in diagnosis and efficacy monitoring of pneumonia in children [J]. Laboratory Medicine, 2023, 38(9): 865-869. |
[14] | SHI Yingying, PAN Fen, SUN Yan, WANG Chun, JIANG Jie, YU Fangyuan, ZHANG Tiandong, QIN Huihong, ZHANG Hong. Nested multiple polymerase chain reaction in rapid diagnosis of meningitis/encephalitis in children [J]. Laboratory Medicine, 2023, 38(8): 766-770. |
[15] | FU Limei, YANG Dan, XU Jin, ZHU Haiyan, ZHU Fenhua. Clinical significance of whole blood trace elements and serum vitamin levels in 6 common skin diseases in children [J]. Laboratory Medicine, 2023, 38(8): 771-775. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||