Abstract:

Objective To investigate the roles of serum hepcidin（Hepc）,cardiac troponin I（cTnI） and homocysteine（Hcy） in patients with coronary heart disease. Methods A total of 120 patients with coronary heart disease were enrolled. There were 40 cases of stable angina pectoris（SAP）,40 cases of unstable angina pectoris（UAP） and 40 cases of acute myocardial infarction（AMI）. A total of 40 healthy subjects were enrolled as healthy control group. The level of Hepc was determined by enzyme-linked immunosorbent assay（ELISA）,cTnI was determined by chemiluminescence,and Hcy was determined by enzymatic cycling assay. Results The level of Hepc in coronary heart disease group was 94.3（36.3-134.6）μg/L,cTnI was 0.180（0.017-0.490）μg/L,and Hcy was （19.3±7.7）μmol/L,which were higher than those in healthy control group（P<0.05）. The levels of Hepc,cTnI and Hcy in SAP group,UAP group and AMI group were increased in turn,respectively（P<0.05）. The level of Hepc was 67.9（33.7-74.5）μg/L in SAP group,which was higher than that in healthy control group [31.6（26.8-39.7）μg/L]（P<0.05）. The areas under receiver operating characteristic（ROC） curves（AUC） of Hepc,cTnI and Hcy in the diagnosis of coronary heart disease were 0.932,0.841 and 0.812,and the optimal cut-off value of Hepc was 36.8 μg/L. The diagnostic sensitivity was 85.3%,and the diagnostic specificity was 98.3%. Conclusions Hepc,cTnI and Hcy can be used as indicators in the diagnosis of coronary heart disease,and Hepc is the indicator with good performance.

Key words: Hepcidin, Cardiac troponin I, Homocysteine, Coronary heart disease