Retrospective analysis of clinical and laboratory examinations' characteristics of mast cell leukemia

doi:10.3969/j.issn.1673-8640.2019.02.020

Abstract

Abstract:

Objective To analyze the clinical and laboratory examinations' characteristics of a case of mast cell leukemia（MCL） retrospectively,and to understand the clinical and laboratory examinations' characteristics of MCL. Methods Through the clinical and pathologic findings,including complete blood count,bone marrow aspiration,flow cytometry,genetic analysis and DNA sequencing in a case of MCL,the clinical and laboratory examinations' characteristics were analyzed combined with literatures. Results Physical examination revealed recurrent diarrhea,asthenia,severe weight loss,urticaria and marked splenomegaly. In peripheral blood and bone marrow,mast cells（MC）accounted for 42% and 79%,respectively. The immunophenotypes of MC were CD45+,CD117++,CD33++,CD13+,CD11b-,CD2++,CD9++,CD123-,partial CD25+,CD34-,CD38-,HLADR-,CD64- and CD15-. No obvious abnormality was found in genetic analysis. F522C was detected by mutational analysis of KIT gene. Eventually,the case was diagnosed as MCL. Conclusions MCL is a rare hematological malignancy with unique clinical and laboratory examinations' characteristics. It should pay attention to the cell morphology to avoid the misidentification of similar cells,and the molecular biological examination should be emphasized to guide the treatment.

Key words: Mast cell leukemia, Morphology, KIT gene mutation

CLC Number:

R446.1

SUN Ye, GUO Ping, XIONG Shumin, WU Rong, KANG Xiangdong. Retrospective analysis of clinical and laboratory examinations' characteristics of mast cell leukemia[J]. Laboratory Medicine, 2019, 34(2): 180-184.

Figures/Tables 3

References 27

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