Changes and correlation of serum cystatin C and myeloperoxidase levels in patients with coronary slow-flow angina pectoris

doi:10.3969/j.issn.1673-8640.2018.03.001

Abstract

Abstract:

bjective To investigate the changes and correlation of serum cystatin C （Cys C）and myeloperoxidase （MPO） levels in patients with coronary slow-flow angina pectoris. Methods A total of 100 patients with coronary slow-flow angina pectoris were enrolled as angina pectoris group. According to treatment efficiency,they were classified into good prognosis group （59 cases） and poor prognosis group （41 cases）. Totally,100 healthy subjects were enrolled as healthy control group. Serum Cys C and MPO levels and corrected thrombolysis in myocardial infarction（TIMI）flow frames were determined. Pearson correlation analysis was used to evaluate the correlation of serum Cys C and MPO with corrected TIMI flow frames. Logistic regression analysis was used to assess whether elevated serum Cys C and MPO levels were risk factors for poor prognosis in patients with coronary slow-flow angina pectoris. Results Serum Cys C and MPO levels and corrected TIMI flow frames in angina pectoris group were higher than those in healthy control group （P<0.001）. Serum Cys C and MPO levels in good prognosis group were lower than those in poor prognosis group （P<0.001）. Pearson correlation analysis showed that serum Cys C and MPO levels were positively correlated with corrected TIMI flow frames （r=0.705 and 0.643,P<0.05）. Logistic regression analysis showed that elevated serum Cys C and MPO levels were independent risk factors for poor prognosis [Cys C：odds ratio （OR）=4.125,95% confidence interval （CI） 3.658-4.756,P=0.000;MPO：OR=6.986,95%CI 5.356-7.967, P=0.000]. Conclusions Serum Cys C and MPO levels are related to the occurrence and development of coronary slow-flow angina pectoris,and serum Cys C and MPO are independent risk factors for poor prognosis. The dynamic determinations of serum Cys C and MPO levels can be used for evaluating the status and prognosis of patients with coronary slow-flow angina pectoris.

Key words: Cystatin C, Myeloperoxidase, Coronary slow-flow angina pectoris

CLC Number:

R446.1

YI Xuejun, ZHANG Ailing, ZHAI Jianxin. Changes and correlation of serum cystatin C and myeloperoxidase levels in patients with coronary slow-flow angina pectoris[J]. Laboratory Medicine, 2018, 33(3): 191-195.

Figures/Tables 6

References 18

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组别	例数	性别（男/女）	年龄（岁）	吸烟史 [例（%）]	高血压史 [例（%）]	糖尿病史 [例（%）]	高血脂史 [例（%）]	SCr （μmol/L）
心绞痛组	100	54/46	60.66±11.63	32（32.00）	59（59.00）	29（29.00）	36（36.00）	73.85±11.63
正常对照组	100	60/40	58.75±10.69	29（29.00）	48（48.00）	35（35.00）	29（29.00）	75.41±13.62
统计值		0.734	1.209	0.212	2.431	0.827	1.117	0.871
P值		0.648	0.782	0.792	0.624	0.217	0.872	0.632

组别	例数	性别（男/女）	年龄（岁）	吸烟史 [例（%）]	高血压史 [例（%）]	糖尿病史 [例（%）]	高血脂史 [例（%）]	SCr （μmol/L）
心绞痛组	100	54/46	60.66±11.63	32（32.00）	59（59.00）	29（29.00）	36（36.00）	73.85±11.63
正常对照组	100	60/40	58.75±10.69	29（29.00）	48（48.00）	35（35.00）	29（29.00）	75.41±13.62
统计值		0.734	1.209	0.212	2.431	0.827	1.117	0.871
P值		0.648	0.782	0.792	0.624	0.217	0.872	0.632

组别	例数	Cys C（mg/L）	MPO（mg/L）	校正TIMI血流帧数（帧）
心绞痛组	100	1.32±0.25	30.82±7.66	48.96±10.66
正常对照组	100	0.75±0.35	9.65±3.74	20.56±2.63
t值		13.250	24.835	25.866
P值		<0.001	<0.001	<0.001

组别	例数	Cys C（mg/L）	MPO（mg/L）	校正TIMI血流帧数（帧）
心绞痛组	100	1.32±0.25	30.82±7.66	48.96±10.66
正常对照组	100	0.75±0.35	9.65±3.74	20.56±2.63
t值		13.250	24.835	25.866
P值		<0.001	<0.001	<0.001

组别	例数	Cys C	MPO
预后良好组	59	0.92±0.25	10.33±3.85
预后不良组	41	1.62±0.35	33.55±8.96
t值		16.275	23.810
P值		<0.001	<0.001