Correlation between peripheral blood lipid level and age-related macular degeneration

doi:10.3969/j.issn.1673-8640.2017.12.007

Abstract

Abstract:

Objective To investigate the correlation between peripheral blood lipid level and age-related macular degeneration（AMD）. Methods A total of 84 AMD patients and 40 healthy subjects were enrolled,and their data of age,sex and disease history were collected. Serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A（apo A） and apolipoprotein B（apo B） were determined. The results were analyzed by univariate analysis and multivariate Logistic regression analysis. Results The levels of TC,TG,HDL-C and apo A in AMD group were higher than those in healthy control group（P<0.05）. Multivariate Logistic regression analysis showed that TC [odds ratio （OR）=2.095,95% confidence interval（CI）1.277-3.434],HDL-C（OR=3.106,95%CI 1.133-8.513） and apo A（OR=3.588,95%CI 0.768-16.752）were risk factors for AMD. Conclusions The increasing levels of peripheral blood TC,HDL-C and apo A may be correlated with the incidence of AMD.

Key words: Blood lipid, Risk factor, Age-related macular degeneration

CLC Number:

R446.1

SHAO Mingxi, LI Shengjie, CAO Wenjun. Correlation between peripheral blood lipid level and age-related macular degeneration[J]. Laboratory Medicine, 2017, 32(12): 1105-1108.

Figures/Tables 2

References 21

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组别	例数	年龄（岁）	性别（男/女）	舒张压（kPa）	收缩压（kPa）	BMI（kg/m²）
AMD组	84	51.67±13.96	30/54	10.91±1.14	17.18±1.23	22.55±2.17
正常对照组	40	46.95±14.56	17/23	11.35±1.15	17.71±1.39	23.18±1.66
统计值		1.696	0.530	1.325	1.427	1.105
P值		0.093	0.467	0.191	0.160	0.274

组别	例数	年龄（岁）	性别（男/女）	舒张压（kPa）	收缩压（kPa）	BMI（kg/m²）
AMD组	84	51.67±13.96	30/54	10.91±1.14	17.18±1.23	22.55±2.17
正常对照组	40	46.95±14.56	17/23	11.35±1.15	17.71±1.39	23.18±1.66
统计值		1.696	0.530	1.325	1.427	1.105
P值		0.093	0.467	0.191	0.160	0.274

组别	例数	TC	TG	HDL-C	LDL-C	apo B	apo A
AMD组	84	4.77±1.12	1.38±0.85	1.63±0.61	2.66±1.08	1.05±0.28	1.73±0.35
正常对照组	40	3.98±0.68	1.04±0.38	1.35±0.21	2.79±0.58	0.98±0.16	1.55±0.17
t值		4.771	3.017	3.818	0.909	1.698	3.710
P值		<0.001	0.003	<0.001	0.365	0.092	<0.001

组别	例数	TC	TG	HDL-C	LDL-C	apo B	apo A
AMD组	84	4.77±1.12	1.38±0.85	1.63±0.61	2.66±1.08	1.05±0.28	1.73±0.35
正常对照组	40	3.98±0.68	1.04±0.38	1.35±0.21	2.79±0.58	0.98±0.16	1.55±0.17
t值		4.771	3.017	3.818	0.909	1.698	3.710
P值		<0.001	0.003	<0.001	0.365	0.092	<0.001