Reference intervals of serum pepsinogen and gastrin-17 levels among healthy population in some areas of Shanghai

doi:10.3969/j.issn.1673-8640.2016.12.002

Abstract

Abstract:

Objective To investigate the reference intervals of serum pepsinogen（PG） Ⅰ,PG Ⅱ and gastrin-17（G-17） levels among healthy population in some areas of Shanghai.Methods Serum PGⅠ,PGⅡ and G-17 levels were determined by enzyme-linked immunosorbent assay（ELISA） in 1 235 healthy subjects,and PGⅠ/PGⅡ ratio was calculated. Results In 1 235 healthy subjects,the levels of PGⅠ,PGⅡ and PGⅠ/PGⅡ ratio showed a skewed distribution,and the reference intervals were established by percentile method. The levels of G-17 showed a normal distribution,and the reference intervals were established by x±1.96s. Males had lower serum PGⅠ and PGⅡ levels than females（P<0.05）,and there was statistical significance for different ages（P<0.05）. It was necessary to establish age-specific and sex-specific reference intervals. There was no statistical significance for serum PGⅠ/PGⅡ ratio between males and females（P>0.05）,and there was statistical significance for different ages（≥4.79 for 18-44 years old,≥5.40 for 45-59 years old and ≥4.35 for ≥60 years old）. For serum G-17 levels,there was no statistical significance for different ages and sex（P>0.05）,and the uniform reference intervals could be established（2.22-6.26 pmol/L）. The reference intervals of PGⅠ were 57.31-159.42 μg/L for males and 60.07-169.68 μg/L for females at the age of 18-44,57.96-158.33 μg/L for males and 64.84-183.50 μg/L for females at the age of 45-59 and 65.28-200.04 μg/L for males and 67.15-188.35 μg/L for females at the age of ≥60. The reference intervals of PGⅡ were ≤12.59 μg/L for males and ≤20.72 μg/L for females at the age of 18-44,≤20.85 μg/L for males and ≤25.33 μg/L for females at the age fo 45-59 and ≤23.10 μg/L for males and ≤27.22 μg/L for females at the age of ≥60. Conclusions The reference intervals of serum PGⅠ,PGⅡ and G-17 levels and PGⅠ/PGⅡ ratio are established for healthy population in some areas of Shanghai.

Key words: Pepsinogen, Gastrin-17, Reference intervals, Healthy population

CLC Number:

R446.1

YANG Jianhua, WANG Binghua, LIN Yong. Reference intervals of serum pepsinogen and gastrin-17 levels among healthy population in some areas of Shanghai[J]. Laboratory Medicine, 2016, 31(12): 1017-1020.

Figures/Tables 2

References 15

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组别	例数	PGⅠ（μg/L）	PGⅡ（μg/L）	PGⅠ/PGⅡ比值	G-17（pmol/L）
男性组	693	98.54（78.65,126.50）	8.63（5.55,12.86）	12.07（8.51,15.33）	4.46±0.20
18~44岁	232	97.17（68.37,126.43）	5.43（3.95,8.63）	14.81（11.56,20.79）	3.93±0.32
45~59岁	247	93.48（79.53,118.35）^#	7.74（5.38,12.94）^#	12.17 （8.56,14.88）^#	4.51±0.71
≥60岁	214	106.63（86.42,135.59）^#△	10.30（7.48,16.11）^#△	10.53（6.83,13.89）^#△	4.50±0.57
女性组	542	114.64（88.19,144.30）^*	9.95（6.26,14.56）^*	11.26（8.28,15.37）	3.24±0.13
18~44岁	226	99.76（74.66,138.13）	6.97（4.94,13.07）	13.33（9.72,17.46）	2.37±0.26
45~59岁	198	116.71（91.66,141.22）^#	9.29（6.16,14.35）^#	11.58 （8.13,15.53）^#	3.11±0.48
≥60岁	118	120.17（97.32,148.27）^#△	11.21（7.96,15.40）^#△	10.31（7.81,13.74）^#△	4.59±0.52

组别	例数	PGⅠ（μg/L）	PGⅡ（μg/L）	PGⅠ/PGⅡ比值	G-17（pmol/L）
男性组	693	98.54（78.65,126.50）	8.63（5.55,12.86）	12.07（8.51,15.33）	4.46±0.20
18~44岁	232	97.17（68.37,126.43）	5.43（3.95,8.63）	14.81（11.56,20.79）	3.93±0.32
45~59岁	247	93.48（79.53,118.35）^#	7.74（5.38,12.94）^#	12.17 （8.56,14.88）^#	4.51±0.71
≥60岁	214	106.63（86.42,135.59）^#△	10.30（7.48,16.11）^#△	10.53（6.83,13.89）^#△	4.50±0.57
女性组	542	114.64（88.19,144.30）^*	9.95（6.26,14.56）^*	11.26（8.28,15.37）	3.24±0.13
18~44岁	226	99.76（74.66,138.13）	6.97（4.94,13.07）	13.33（9.72,17.46）	2.37±0.26
45~59岁	198	116.71（91.66,141.22）^#	9.29（6.16,14.35）^#	11.58 （8.13,15.53）^#	3.11±0.48
≥60岁	118	120.17（97.32,148.27）^#△	11.21（7.96,15.40）^#△	10.31（7.81,13.74）^#△	4.59±0.52

项目	性别	年龄（岁）	x±s或P₅~P₉₅	参考区间
PGⅠ（μg/L）	男性	18~44	57.31~159.42	57.31~159.42
		45~59	57.96~158.33	57.96~158.33
		≥60	65.28~200.04	65.28~200.04
	女性	18~44	60.07~169.68	60.07~169.68
		45~59	64.84~183.50	64.84~183.50
		≥60	67.15~188.35	67.15~188.35
PGⅡ（μg/L）	男性	18~44	2.19~12.59	≤12.59
		45~59	3.51~20.85	≤20.85
		≥60	5.00~23.10	≤23.10
	女性	18~44	2.86~20.72	≤20.72
		45~59	3.51~25.33	≤25.33
		≥60	5.04~27.22	≤27.22
PGⅠ/PGⅡ比值	男性+女性	18~44	4.89~27.12	≥4.79
	男性+女性	45~59	5.40~22.31	≥5.40
	男性+女性	≥60	4.35~24.31	≥4.35
G-17（pmol/L）	男性+女性	18~≥60	4.24±1.03	2.22~6.26

项目	性别	年龄（岁）	x±s或P₅~P₉₅	参考区间
PGⅠ（μg/L）	男性	18~44	57.31~159.42	57.31~159.42
		45~59	57.96~158.33	57.96~158.33
		≥60	65.28~200.04	65.28~200.04
	女性	18~44	60.07~169.68	60.07~169.68
		45~59	64.84~183.50	64.84~183.50
		≥60	67.15~188.35	67.15~188.35
PGⅡ（μg/L）	男性	18~44	2.19~12.59	≤12.59
		45~59	3.51~20.85	≤20.85
		≥60	5.00~23.10	≤23.10
	女性	18~44	2.86~20.72	≤20.72
		45~59	3.51~25.33	≤25.33
		≥60	5.04~27.22	≤27.22
PGⅠ/PGⅡ比值	男性+女性	18~44	4.89~27.12	≥4.79
	男性+女性	45~59	5.40~22.31	≥5.40
	男性+女性	≥60	4.35~24.31	≥4.35
G-17（pmol/L）	男性+女性	18~≥60	4.24±1.03	2.22~6.26

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