Abstract:

Objective To investigate the roles of serum pepsinogen（PG）Ⅰ,PGⅡ,pepsinogenⅠ/pepsinogenⅡ ratio（PGR） and gastrin 17（G-17） in healthy examination. Methods The levels of serum PGⅠ,PGⅡ and G-17 were determined by enzyme-linked immunosorbent assay（ELISA） in 1 872 healthy subjects. PGR was calculated. The relations of serum PGⅠ,PGⅡ,PGR and G-17 with sex and age were evaluated. The results of the combined determination of serum PG and G-17 were compared those of gastroscopy. Results The levels of serum PGⅠand PGR had statistical significance between males and females（P<0.001）,while the levels of PGⅡand G-17 had no statistical significance（P>0.05）. The levels of serum PGⅠ and PGⅡ were increased with the increasing of ages,while PGR was decreased. Serum G-17 reached a plateau in 21-50 years old,while it was gradually increased after 50 years old. There was no statistical significance in the positive rates of serum PG and G-17 and the double positive rate of serum PG and G-17 between males and females（P>0.05）,and the positive rate of serum G-17 was higher than that of serum PG（P<0.001）. Compared with the results of gastroscopy,the positive coincidence rate of the combined determination of serum PG and G-17 was 12.5%. Conclusions The combined determination of serum PG and G-17 is important in the screening of gastric-related diseases,which can be applied in healthy examination.

Key words: Pepsinogen Ⅰ, Pepsinogen Ⅱ, PepsinogenⅠ/pepsinogenⅡ ratio, Gastrin 17, Healthy examination