Clinical significance of serum pepsinogen and anti-Hp IgG antibody in the diagnosis of peptic ulcer

doi:10.3969/j.issn.1673-8640.2014.11.011

Abstract

Abstract:

Objective　 To investigate the clinical significance of serum pepsinogen (PG) and anti-Helicobacter pylori (Hp) IgG antibody in the diagnosis of peptic ulcer. Methods　A total of 115 peptic ulcer patients (peptic ulcer group) were found by attending physical examination from October 2007 to December 2012 in Huadong Sanatorium of Shanghai, including 65 cases of gastric ulcer and 50 cases of duodenal ulcer. A total of 90 healthy subjects were enrolled as controls, and the sex and age ratios were the same with those in peptic ulcer group. The levels of serum PGⅠ and PGⅡ were measured by latex-enhanced immunoturbidimetry, and the PGⅠ/Ⅱratio(PGR)was calculated. The serum anti-Hp IgG antibody was determined by enzyme-linked immunosorbent assay (ELISA). Results　In peptic ulcer group, the serum levels of PGⅠand PGⅡand PGR were (180.14±20.56) ng/mL, (24.98±10.14) ng/mL and 7.87±1.29, respectively, which were significantly higher than those in control group (P<0.05).The positive rate of anti-Hp IgG antibody infection in peptic ulcer group was 77.4%, and that in control group was 23.3%, with statistical significance(P<0.05).Serum PGⅠ and PG Ⅱlevels and PGR in HP positive group were (165.35±22.14) ng/mL, (20.75±11.26) ng/mL and 7.64±2.03, respectively, which were significantly higher than those in HP negative group (P<0.05). Conclusions　The serum PG and anti-Hp IgG antibody are related closely with peptic ulcer changes, and they can be used for the early screening of peptic ulcer.

Key words: Pepsinogen, Anti- IgG antibody, Peptic ulcer

CLC Number:

R446.62

ZHAO Lanjing, LIU Chunxing, AN Xianyuan.. Clinical significance of serum pepsinogen and anti-Hp IgG antibody in the diagnosis of peptic ulcer[J]. , 2014, 29(11): 1124-1127.

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