Abstract:

Objective To investigate the significance of serum vascular endothelial growth factor（VEGF） in lung cancer. Methods The levels of serum VEGF were determined by enzyme-linked immunosorbent assay（ELISA） in 142 patients with lung cancer,30 patients with lung diseases and 25 healthy subjects. Meanwhile,their tumor stages and serum VEGF expression changes before and after chemotherapy and surgery were compared. The receiver operating characteristic（ROC） curve was used to evaluate the significance of serum VEGF in lung cancer. SPSS 13.0 software was used for statistical analysis. Results Serum VEGF level in lung cancer group was 154.09（86.81,260.01） pg/mL,which was higher than that in healthy control group [59.06（27.66,77.81）pg/mL,P<0.01]. Serum VEGF level had no statistical significance for different pathological types of lung cancer group（P=0.493）. Serum VEGF levels before and after chemotherapy had no statistical significance（P>0.05）. Serum VEGF levels with different M stages and tumor stages in non-small cell lung cancer had statistical significance（P<0.05）,and there was no statistical significance between localized and extensive stages（P>0.05）. The area under ROC curve of serum VEGF in the diagnosis of lung cancer was 0.664,and that for non-small cell lung cancer distant metastasis was 0.666. Conclusions The expression of serum VEGF is abnormal in lung cancer group,and it is related to the clinical stages of lung cancer. It is of significance in the diagnosis and metastasis of lung cancer.

Key words: Vascular endothelial growth factor, Lung cancer, Chemotherapy, Surgery