Application of oligoclonal bands in the diagnosis of central nervous system diseases

doi:10.3969/j.issn.1673-8640.2015.11.022

Abstract

Abstract:

The strong immune response produced by central nervous system(CNS)is the pathological basis on the occurrence and development of some autoimmune nervous diseases, characterized by immunoglobulin composition and content in cerebrospinal fluid(CSF).The CSF oligoclonal bands(OCB)are the specific antibodies produced by several B-cell strains(clone) located in CNS, which is a specific reaction for CNS.The presence of OCB in CSF often indicates that intrathecal immunoglobulin synthesis were produced in CNS.It has certain clinical significance to diagnose CNS diseases by OCB, especially for the diagnosis of CNS demyelinating diseases, like multiple sclerosis (MS).

Key words: Oligoclonal band, Central nervous system, Cerebrospinal fluid, Diagnosis

CLC Number:

R446.62

MENG Jun, PENG Yibing, ZHANG Dongqing. Application of oligoclonal bands in the diagnosis of central nervous system diseases[J]. Laboratory Medicine, 2015, 30(11): 1157-1160.

Figures/Tables 1

References 22

[1]	DEISENHAMMER F,BARTOS A,EGG R,et al.Guidelines on routine cerebrospinal fluid analysis.Report from an EFNS task force[J].Eur J Neurol,2006,13(9):913-922.
[2]	ANDERSSON M,ALVAREZS-CERMENO J, BERNARDI G, et al.Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report[J].J Neurol Neurosurg Psychiatry, 1994,57(8):897-902.
[3]	SOUVERJIN JH,SERREE HM,PEET R,et al.Intrathecal immunoglobulin synthssis.Comparison of various formulae with the 'gold standard' of isoelectric focusing[J].J Neurol Sci,1991,102(1):11-16.
[4]	CORREALE J,DE LOS MILAGROS BASSANI MOLINAS M. Oligoclonal bands and antibody responses in multiple sclerosis[J].J Neurol,2002,249(4):375-389.
[5]	HOLMOY T.The discovery of oligoclonal bands: a 50-year anniversary[J]. Eur Neurol, 2009, 62(5):311-315.
[6]	DISANTO G, MORAHAN JM, BARNETT MH, et al.The evidence for a role of B cells in multiple sclerosis[J].Neurology,2012,78(11):823-832.
[7]	KARUSSIS D, VOURKA-KARUSSIS U, MIZRACHI-KOLL R, et al.Acute/relapsing experimental autoimmune encephalomyelitis: induction of long lasting,antigen-specific tolerance by syngeneic bone marrow transplantation[J]. Mult Scler, 1999, 5(1): 17-21.
[8]	SKOV AG, SKOV T, FREDERIKSEN JL.Oligoclonal bands predict multiple sclerosis after optic neuritis: a literature survey[J].Mult Scler,2011 ,17(4):404-410.
[9]	PETZOLD A.Intrathecal oligoclonal IgG synthesis in multiple sclerosis[J].J Neuroimmunol,2013, 262(1-2):1-10.
[10]	吕礼应. 免疫透射比浊测定脑脊液免疫球蛋白[J].检验医学,2003 ,18(4): 223-225.
[11]	FRANCIOTTA D,BERGAMASCHI R, AMATO MP,et al.Clinical correlations of CSF single IgG bands[J].J Neurol,2005,252(10):1274-1275.
[12]	POLMAN CH,REINGOLD SC,EDAN G,et al.Diagnostic criteria for multiple sclerosis:2005 revisions to the"McDonald Criteria"[J]. Ann Neurol,2005,58(6):840-846.
[13]	方明,乔健.寡克隆区带和IgG指数对多发性硬化的诊断价值[J].临床神经病学杂志,2004,17(4):247-249.
[14]	NAKASHIMA I,FUJIHARA K,MISU T,et al.A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands[J].Mult Scler,2002,8(6):459-462.
[15]	FUKAZAWA T,KIKUEHI S,SASAKI H,et al.The significance of oligoclonal bands in multiple sclerosis in Japan:relevance of immunogenetic backgrounds[J].J Neurol Sci,1998 ,158(2):209-214.
[16]	KIKUCHI S,FUKAZAWA T,NIINO M,et al.HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands.Human leukocyte antigen[J].Neurology,2003, 60(4):647-651.
[17]	NAKASHIMA I,FUJIHARA K,MIYAZAWA H.Relevance of callosal and periventrieular MRI lesions to oligoelonal bands in multiple sclerosis[J].Acta Neurol Scand,2006,113(2):125-131.
[18]	HUTTNER HB, SCHELLINGER PD, STRUFFERT T, et al. MRI criteria in MS patients with negative and positive oligoclonal bands:equal fulfill-ment of Barkho's criteria but different lesion patterns[J].J Neurol,2009,256(7):1121-1125.
[19]	DOBSON R, RAMAGOPALAN S, DAVIS A, et al.Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude[J].J Neurol Neurosurg Psychiatry,2013,84(8):909-914.
[20]	ZAFFARONI M.Cerebrospinal fluid fingings in Devic's neuromyelitis optica[J]. Neurol Sci,2004,25(Suppl 4):S368-S370.
[21]	JURYN'CZYK M, CRANER M, PALACE J.Overlapping CNS inflammatory diseases: differentiating features of NMO and MS[J].J Neurol Neurosurg Psychiatry,2015,86(1):20-25.
[22]	MOULIN D,PATY DW,EBERS GC.The predictive value of cerebrospinal fluid electrophoresis in 'possible'multiple sclerosis[J].Brain,1983,106(Pt 4):809-816.