Study on the application significance of ischemia modified albumin in early diagnosis of acute coronary syndrome

doi:10.3969/j.issn.1673-8640.2015.06.008

Abstract

Abstract: Objective

To observe the changes of ischemia modified albumin(IMA) in patients with acute coronary syndrome(ACS), and investigate the application significance of IMA in early diagnosis of ACS.

Methods

The serum concentrations of IMA, MB isoenzyme of creatine kinase MB (CK-MB) and cardiac troponin T(cTnT) were continuously monitored at 2, 6, 12, 24 and 48h after onset in ACS patients with acute chest pain, including 43 cases of acute myocardial infarction (AMI) and 54 cases of unstable angina pectoris (UAP), and were compared with 42 suspected cases of ACS (control group). Their applications for the early diagnosis of ACS were evaluated.

Results

IMA was higher in patients with UAP and AMI at 2 h after chest pain onset than healthy control group(P<0.05). The serum IMA reached a peak level at 12 h after the onset of chest pain and dropped to the same level as that of control group at 24 h. CK-MB and cTnT had no statistical significance in any determination time among the UAP patients. Receiver operating characteristic (ROC) curves showed that the areas under the curve (AUC) of IMA, CK-MB and cTnT were 0.812, 0.781 and 0.648, respectively at 2 h after chest pain onset.

Conclusions

IMA may be a sensitive biomarker for the myocardial ischemia of ACS patients, which can be used into the early diagnosis of AMI.

Key words: Ischemia modified albumin, Cardiac troponin T, MB isoenzyme of creatine kinase, Acute coronary syndrome

CLC Number:

R446.1

ZHANG Ping, ZHOU Hongxing, BAI Yang, XU Zhe, SUN Yingxin, WANG Xin, WANG Sujian, ZHANG Hong. Study on the application significance of ischemia modified albumin in early diagnosis of acute coronary syndrome[J]. Laboratory Medicine, 2015, 30(6): 581-584.

Figures/Tables 3

References 12

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组别	例数	胸痛发作2 h			胸痛发作6 h
组别	例数	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)
UAP组	54	90.05±14.42^*	8.3±3.6	15.78±7.16	95.67±13.16^*	8.5±3.5	17.69±8.21
AMI组	43	106.68±34.11^**	10.2±0.8	29.97±12.38^*	113.74±34.96^**	26.8±10.6^*	45.73±16.55^**
对照组	42	76.37±10.12	7.8±3.9	11.40±7.14	79.25±10.31	7.9±3.8	11.50±7.12
组别	例数	胸痛发作12 h			胸痛发作24 h
组别	例数	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)
UAP组	54	98.19±13.26^*	9.1±4.3	14.62±6.99	64.29±11.95	8.3±3.9	10.78±5.62
AMI组	43	115.13±30.91^*	31.2±17.2^**	49.81±23.76^**	65.17±12.74	35.5±7.9^**	35.18±15.66^*
对照组	42	66.83±9.68	7.8±3.8	11.30±7.10	57.68±7.73	7.9±3.7	11.50±7.13
组别	例数	胸痛发作48 h
组别	例数	IMA(U/mL)	cTnT(×10^-3ng/mL)		CK-MB(U/L)
UAP组	54	59.34±10.76	8.1±3.7		10.16±5.46
AMI组	43	58.66±10.82	36.7±8.2^**		30.28±14.96^*
对照组	42	57.16±7.51	7.8±3.9		11.40±7.16

组别	例数	胸痛发作2 h			胸痛发作6 h
组别	例数	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)
UAP组	54	90.05±14.42^*	8.3±3.6	15.78±7.16	95.67±13.16^*	8.5±3.5	17.69±8.21
AMI组	43	106.68±34.11^**	10.2±0.8	29.97±12.38^*	113.74±34.96^**	26.8±10.6^*	45.73±16.55^**
对照组	42	76.37±10.12	7.8±3.9	11.40±7.14	79.25±10.31	7.9±3.8	11.50±7.12
组别	例数	胸痛发作12 h			胸痛发作24 h
组别	例数	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)	IMA (U/mL)	cTnT (×10^-3ng/mL)	CK-MB (U/L)
UAP组	54	98.19±13.26^*	9.1±4.3	14.62±6.99	64.29±11.95	8.3±3.9	10.78±5.62
AMI组	43	115.13±30.91^*	31.2±17.2^**	49.81±23.76^**	65.17±12.74	35.5±7.9^**	35.18±15.66^*
对照组	42	66.83±9.68	7.8±3.8	11.30±7.10	57.68±7.73	7.9±3.7	11.50±7.13
组别	例数	胸痛发作48 h
组别	例数	IMA(U/mL)	cTnT(×10^-3ng/mL)		CK-MB(U/L)
UAP组	54	59.34±10.76	8.1±3.7		10.16±5.46
AMI组	43	58.66±10.82	36.7±8.2^**		30.28±14.96^*
对照组	42	57.16±7.51	7.8±3.9		11.40±7.16

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