Abstract:

Objective To investigate the roles of endothelin-1（ET-1）,endothelial microparticle（EMP） and high-sensitivity cardiac troponin T（hs-cTnT） in patients with ischemic heart disease. Methods Serum levels of ET-1,EMP and hs-cTnT were determined in 98 patients with ischemic heart disease（ischemic heart disease group）and 100 healthy subjects（healthy control group）. According to the New York Heart Association（NYHA） cardiac function classification,there were 27 patients with NYHA class Ⅰ,34 patients with class Ⅱ,25 patients with class Ⅲ and 12 patients with class Ⅳ. According to Gensini score,98 patients were classified into mild stenosis（32 cases）,moderate stenosis（45 cases） and severe stenosis（21 cases）. Results The levels of ET-1,EMP and hs-cTnT in ischemic heart disease group were significantly higher than those in healthy control group（P<0.05）. The levels of ET-1,EMP and hs-cTnT in patients with NYHA class Ⅳ and Ⅲ were significantly higher than those in patients with NYHA class Ⅰ and Ⅱ（P<0.05）. Moreover,patients with NYHA class Ⅳ had higher levels of ET-1,EMP and hs-cTnT than those with NYHA class Ⅲ（P<0.05）. The levels of ET-1,EMP and hs-cTnT in patients with mild,moderate and severe stenosis increased in turn（P<0.05）. Conclusion The levels of ET-1,EMP and hs-cTnT are correlated with the grade of cardiac function and the degree of coronary artery stenosis in patients with ischemic heart disease.

Key words: Endothelin-1, Endothelial microparticle, High-sensitivity cardiac troponin T, Ischemic heart disease