Analysis on the correlations of 25-hydroxyvitamin D concentrations with HCV RNA loads and cirrhosis severity in hepatitis C patients

doi:10.3969/j.issn.1673-8640.2015.05.007

Abstract

Abstract:

Objective　To investigate the correlations of serum 25-hydroxyvitamin D[25（OH）D]concentrations with hepatitis C virus（HCV）RNA loads and cirrhosis severity in hepatitis C patients. Methods　A total of 271 hepatitis C patients and 218 healthy subjects were enrolled， and their serum samples were collected. Serum 25（OH）D concentrations and HCV RNA loads were determined. Moreover， serum alpha 2-macroglobulin（α2M）， haptoglobin（HPT）， apolipoprotein A1（apo A1）， total bilirubin（TBil）and gamma-glutamyl transpeptidase（GGT）concentrations were determined. According to Fibrotest classification， the severity of cirrhosis was evaluated. The 25（OH）D concentrations between hepatitis C and healthy control groups were compared. Furthermore， the difference of serum 25（OH）D between HCV RNA positive group and HCV RNA negative group was also evaluated. The correlation between serum 25（OH）D concentrations and HCV RNA loads in HCV RNA positive group was analyzed. Hepatitis C patients were classified according to the quartile concentrations of 25（OH）D， and the correlation between serum 25（OH）D concentrations and Fibrotest classification was investigated. Results　Serum 25（OH）D concentrations were significantly higher in healthy control group than in hepatitis C group[means were（60.42±1.34） nmol/L and（49.31±1.39） nmol/L， P＜0.01]. The proportions of patients with the deficiency of 25（OH）D（＜50 nmol/L）and the ones with severe deficiency（＜25 nmol/L） in hepatitis C group were 41.33%（112/271）and 14.40%（39/271）， which were significantly higher than those in healthy control group[27.98%（61/218） and 3.67%（8/218）]（P＜0.01）. No significant difference for serum 25（OH）D concentrations was observed between HCV RNA positive and HCV RNA negative groups[means were 48.98±21.59 and（49.89±25.27） nmol/L， P＞0.05]. Linearity regression revealed that there was no correlation between the logarithmic of HCV RNA loads and the concentration of 25（OH）D in HCV RNA positive group（r=0.056， P=0.412）. Moreover， there was no statistical significance for the proportion of patients with different Fibrotest classifications（F0-F1， F1-F3 and F3-F4）between the highest quartile concentration and the lowest quartile concentration of 25（OH）D [means were 49.12±5.80， 48.27±4.90 and（49.89±8.20） nmol/L， P＞0.05]. Conclusions　The hepatitis C patients are prone to encounter 25（OH）D deficiency compared with healthy subjects， which implys that these patients are suggested to uptake vitamin D supply. Furthermore， no clinical correlation is found between the logarithmic of HCV RNA loads， cirrhosis severity and the concentrations of 25（OH）D.

Key words: 25-hydroxyvitamin D, Hepatitis C, Hepatitis C virus, Fibrotest classification

CLC Number:

R446.1

SONG Binbin, ZHOU Yan, WU Wenhao, WU Jiong, ZHANG Chunyan, WANG Beili, GUO Wei, PAN Baishen. Analysis on the correlations of 25-hydroxyvitamin D concentrations with HCV RNA loads and cirrhosis severity in hepatitis C patients[J]. , 2015, 30(6): 575-580.

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