Early diagnosis significance of immature granulocyte flag in patients with sepsis

doi:10.3969/j.issn.1673-8640.2015.03.008

Abstract

Abstract: Objective

To investigate the early diagnosis significance of immature granulocyte (IG) in patients with sepsis.

Methods

A total of 185 in patients with suspected sepsis in our hospital between January 2008 and June 2013 were enrolled. Their relative data were analyzed retrospectively. The blood culture and peripheral blood IG warning flag results were analyzed statistically.

Results

Among the 185 cases, there were 134 cases of blood culture positive. There were IG ≤0.50% (7 cases), IG ≤3.00% (32 cases), IG ≤4.00% (65 cases) and IG >4.00% (30 cases). Blood culture negative had 51 cases in the 185 cases, and IG ≤0.50% (26 cases), IG ≤3.00% (17 cases), IG ≤4.00% (5 cases) and IG >4.00% (3 cases). It was significant between IG >3.00% group and the other groups(P<0.05), when the results of blood culture was positive. It was significant between IG ≤3.00% group and the other groups(P<0.05), when the results of blood culture was negative.

Conclusions

The results of IG >3.00% can be used as a early auxiliary diagnosis index for patients with sepsis. It has specificity in the diagnosis of sepsis.

Key words: Immature granulocyte, Sepsis, Blood culture

CLC Number:

R446.11

WANG Lejian, SHI Chunjuan, LI Fei, ZHANG Xiwen. Early diagnosis significance of immature granulocyte flag in patients with sepsis[J]. Laboratory Medicine, 2015, 30(3): 238-239.

组别	例数	血培养阳性 (134例)	血培养阴性 (51例)
A组	33	7(21.21)	26(78.79)
B组	54	37(68.52)	17(31.48)
C组	70	65(92.86)^*#	5(7.14)^*#
D组	28	25(89.29)^*#	3(10.71)^*#

组别	例数	血培养阳性 (134例)	血培养阴性 (51例)
A组	33	7(21.21)	26(78.79)
B组	54	37(68.52)	17(31.48)
C组	70	65(92.86)^*#	5(7.14)^*#
D组	28	25(89.29)^*#	3(10.71)^*#

组别	敏感性	特异性	阳性预测值	阴性预测值
IG≤3.00%	86.27	71.67	72.13	86.00
IG>3.00%	75.28	86.44	94.37	53.68

组别	敏感性	特异性	阳性预测值	阴性预测值
IG≤3.00%	86.27	71.67	72.13	86.00
IG>3.00%	75.28	86.44	94.37	53.68

[1]	刘宁, 刘金辉, 姚全良. PCR法检测16S rRNA基因在败血症诊断中的价值[J]. 山东医药, 2010,50(3):97-98.
[2]	伍海英. BD BACTEC 9120全自动血培养仪阳性结果分析[J]. 检验医学与临床,2010,7(2):128-129.
[3]	周庭银, 赵虎, 何铭君. ESP全自动血培养仪的临床应用及评价[J]. 检验医学, 2005,20(1):46-48.
[4]	江虹, 曾婷婷, 刘怡玲, 等. 未成熟粒细胞检测的评估及参考范围的建立[J]. 检验医学, 2010,25(3):171-175.
[5]	刘成玉, 罗春丽, 吴晓蔓, 等. 临床检验医学[M]. 5版. 北京: 人民卫生出版社, 2012:96-125.
[6]	NIGRO KG, O'RIORDAN M, MOLLOY EJ, et al. Performance of an automated immature granulocyte count as a predictor of neonatal sepsis[J]. Am J Clin Pathol, 2005,123(4):618-624.
[7]	杨惠. 古老血常规的新参数: IG/IPF/HET-He/AL/Anb L[J]. 检验医学, 2010,25(11):829-831.

Early diagnosis significance of immature granulocyte flag in patients with sepsis

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 2

References 7

Related Articles 15

Recommended Articles

Metrics

[1]	ZHAO Lixiao, YANG Xiaoting, LI Dan, ZHANG Nan, SU Haiyan, WANG Yan. Diagnostic roles of serum syndecan-1 and eNAMPT levels in patients with severe pneumonia complicated with sepsis [J]. Laboratory Medicine, 2025, 40(9): 856-861.
[2]	YAO Lifeng, ZHANG Ling. Research progress on clinical significance of monocyte distribution width in infection and inflammatory diseases [J]. Laboratory Medicine, 2025, 40(5): 503-507.
[3]	ZHANG Haoyang, LU Lin, ZONG Ming, HE Long, DING Yuanyuan, FAN Lieying. Diagnostic and predictive value of white blood cell population data in patients with sepsis [J]. Laboratory Medicine, 2025, 40(3): 271-277.
[4]	WANG Tiankai, LIU Lin, JIN Peipei, WANG Fang, DING Ning. Clinical value of new neutrophil parameter NEU-X，NEU-Y and NEU-Z in diagnosis of sepsis [J]. Laboratory Medicine, 2024, 39(7): 682-686.
[5]	JIANG Jingjing, GU Ping, WANG Chengyun, ZHANG Fan, SHEN Huiying, PAN Qiuhui, WANG Jing. Changes and clinical significance of procalcitonin and coagulation function indicators in children with sepsis [J]. Laboratory Medicine, 2024, 39(6): 573-577.
[6]	YANG Huilin, CHEN Juan, YAN Jinjin, OU Jiawen, WEN Mingming, ZHOU Lina. Analysis of 4 blood culture bottles' adsorption capacity to 4 commonly used antibiotics [J]. Laboratory Medicine, 2024, 39(6): 578-582.
[7]	LI Anqi, ZHANG Shuya, HE Shanna, CHEN Qiaoqiao, LÜ Qi, LÜ Wanfei, LI Chunxian, WANG Weihua, ZHENG Lin. Rapid bacterial identification and drug susceptibility test of blood culture-positive samples [J]. Laboratory Medicine, 2024, 39(3): 243-248.
[8]	MENG Qiang, WANG Shuang, BAI Zhou, HUANG Qian, FU Yang. Role of TLR9 of red blood cell membrane surface in sepsis patients with anemia [J]. Laboratory Medicine, 2024, 39(10): 933-938.
[9]	MA Yan, ZHOU Chunmei, HUANG Shenglei, WANG Beili, PAN Baishen, GUO Wei. Application evaluation of 24 h satellite blood culture to improve pathogenic microorganism culture process in emergency [J]. Laboratory Medicine, 2024, 39(10): 993-998.
[10]	LIANG Dong, MEI Yue, WANG Tengjiao, YU Dong. Characteristic of blood microbiota of postoperative sepsis based on cfDNA NGS [J]. Laboratory Medicine, 2023, 38(8): 753-759.
[11]	CHEN Hanlu, WU Shenghai. Influence factors of blood culture negative results and progress of pathogen detection in bloodstream infection [J]. Laboratory Medicine, 2022, 37(7): 688-694.
[12]	CHU Minjun, LI Xiaojuan, HUANG Hailin, LI Jue, MA Mingbiao, DU Tingyi, WANG Haiping. Influence of delayed entry on fastidious bacterium culture in 2 blood culture systems [J]. Laboratory Medicine, 2022, 37(3): 209-212.
[13]	YANG Xi, SONG Wenqi, DONG Fang, MENG Qingying, ZHEN Jinghui, ZHOU Wei. Application of Gram staining and MALDI-TOF MS in the rapid identification of pathogen kinds in children's positive blood culture [J]. Laboratory Medicine, 2022, 37(10): 969-973.
[14]	LI Yanchun, TIAN Bin, YUE Na, HU Zhidong. Analysis for distribution and drug resistance of fungemia pathogen from 2014 to 2020 in a Tianjin hospital [J]. Laboratory Medicine, 2021, 36(8): 800-804.
[15]	YU Jiajia, LI Yuanrui, LIU Ying. MALDI-TOF MS combined with SDS and SAP pretreatment for rapid identification of positive blood culture [J]. Laboratory Medicine, 2021, 36(8): 864-868.