Abstract:

Objective　To investigate the clinical significance of Sysmex XT-2000i automatic hematology analyzer's neutrophil parameter NEUT-X and NEUT-Y in the diagnosis of bacterial infection. Methods　Blood samples were collected from 114 patients with bacterial infection,96 patients with bacterial culture negative and 142 healthy subjects(healthy control group) to detect and analyze NEUT-X,NEUT-Y,C-reactive protein (CRP) and toxity indices (TI). Results　NEUT-X and NEUT-Y were 1 391.4±42.3 and 450.9±40.9 respectively in bacterial infection group,which were significantly higher than in bacterial culture negative group (1 344.5±37.0 and 422.7±45.9) and healthy control group(1 351.7±33.7 and 415.8±32.2) with statistical significance(P<0.01). NEUT-X and NEUT-Y were correlated with CRP and TI. For the diagnosis of bacterial infection,CRP had the best diagnosis efficacy,and NEUT-X had the secondary diagnosis efficacy. When the cut-off value of CRP and NEUT-X were 20.5 and 1 370.5,the sensitivities were 94.7% and 71.4%,and the specificities were 71.4% and 75.6%,respectively. Conclusions　NEUT-X and NEUT-Y parameters increase significantly after bacterial infection. It can be used as assistant diagnosis parameters of bacterial infection.

Key words: Bacterial infection, Neutrophil, NEUT-X, NEUT-Y, C-reactive protein