Abstract: Objective　To investigate the correlation of primary hepatic carcinoma and hepatitis B virus（HBV） YMDD variation.   Methods　By real-time fluorescence polymerase chain reaction（PCR），the detection of HBV YMDD variation was performed. Combined with the results of serum biochemical markers，alanine aminotransferase（ALT） and aspartate aminotransferase（AST），the correlation of primary hepatic carcinoma with chronic hepatitis B（CHB），liver cirrhosis（LC） and hepatocellular carcinoma（HCC） was analyzed. Results　In HCC group，LC group and CHB group，HBV YMDD mutation rates were 11.67%（7/60），31.67%（19/60） and 26.67%（16/60）. In HCC group，LC group and CHB group，the activities of ALT were 56（25-113），61（23-301） and 58（31-267） U/L，and the activities of AST were 105（39-137），64（25-109） and 55（33-214） U/L. In 60 cases of HCC，7 cases showed positive HBV YMDD mutations，and the mutation rate was 11.67%. Conclusions　The occurrence of primary hepatic corcinoma and HBV YMDD variation does not exist significant correlation. AST can reflect the severity of liver injury induced by HBV better than ALT. ALT is a sensitive indicator of liver function associated with HBV YMDD variation，and is conducive to disease monitoring.

Key words: YMDD variation, Hepatitis B virus, Polymerase chain reaction, Primary hepatic carcinoma