Role of monoamine oxidase in assessing the severity of coronary artery lesions in ACS patients of different ages

doi:10.3969/j.issn.1673-8640.2026.01.006

Abstract

Abstract:

Objective To investigate the role of monoamine oxidase（MAO）in assessing the severity of coronary artery lesions in patients with acute coronary syndrome（ACS）of different age groups. Methods A total of 262 ACS patients who underwent coronary angiography at Dazhu Hospital Affiliated to North Sichuan Medical College from January 2022 to August 2023 were enrolled. Totally，242 patients with normal coronary angiography results were used as control group. The clinical data（age，gender，smoking history，diabetes mellitus history，hypertension history，body mass index and so on）and routine biochemical determination results were collected. Serum MAO levels were also determined. All the patients were classified by age into young（18 years old to < 40 years old），middle-aged（40 years old to < 60 years old）and elderly（≥60 years old）groups. ACS patients were classified into single-vessel lesion group（80 cases），double-vessel lesion group（111 cases）and triple-vessel lesion group（71 cases）according to the results of coronary angiography. The severity of coronary artery lesions in ACS patients was evaluated using the Gensini score，and they were classified into low value（< 45 points）group（84 cases），medium value（45 points to < 65 points）group（108 cases）and high value（≥65 points）group（70 cases） according to the tertile method. A high Gensini score（indicating severe coronary artery lesions）was defined as Gensini score ≥45 points. Pearson correlation analysis was used to evaluate the correlation between MAO and other indicators. Multivariate Logistic regression analysis was used to evaluate the relationship between MAO and the risk of ACS occurrence. Receiver operating characteristic（ROC）curve was used to evaluate the efficacy of MAO in determining the occurrence of severe coronary artery lesions in ACS patients of different age groups. Results The MAO level in ACS group was higher than that in control group（P<0.001）. After adjusting for clinical data and routine biochemical indicators，high-level MAO was an independent risk factor for ACS occurrence [odds ratio（OR）=3.60，95% confidence interval（CI）2.27-5.71，P<0.001]. In control group，the MAO level of elderly patients was higher than that of middle-aged and young patients（P<0.05），and there was no statistical significance in the MAO levels between middle-aged and young patients（P>0.05）. In ACS group，the MAO levels of young，middle-aged and elderly patients were increased successively（P<0.001）. The MAO levels were increased successively among single-vessel group，double-vessel group，triple-vessel group and among low value，medium value and high value groups of Gensini score（P<0.001），and among all the groups，the MAO levels of young，middle-aged and elderly patients were increased successively（P<0.05）. MAO in ACS patients was positively correlated with cardiac troponin I（cTnI），high-sensitivity C-reactive protein（hs-CRP）and Gensini score（P<0.05）. The areas under curves（AUC）of serum MAO for diagnosing severe coronary artery lesions in elderly，middle-aged and young ACS patients were 0.867，0.843 and 0.732，respectively. Conclusions Serum MAO levels are related to the lesion vessel number and severity of coronary artery lesions in ACS patients and increase age-dependently. Its efficacy in determining the severity of coronary artery lesions in middle-aged and elderly ACS patients is higher.

Key words: Monoamine oxidase, Acute coronary syndrome, Age

CLC Number:

Q554

TIAN Xiangquan, FAN Zhongcai. Role of monoamine oxidase in assessing the severity of coronary artery lesions in ACS patients of different ages[J]. Laboratory Medicine, 2026, 41(1): 34-40.

Figures/Tables 11

References 25

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组别	例数	年龄/岁	性别		吸烟史/ [例（%）]	糖尿病史/ [例（%）]	高血压史/ [例（%）]	体重指数/ （kg·m-2）
组别	例数	年龄/岁	男/[例（%）]	女/[例（%）]	吸烟史/ [例（%）]	糖尿病史/ [例（%）]	高血压史/ [例（%）]	体重指数/ （kg·m-2）
对照组	242	57.46±15.27	126（52.07）	116（47.93）	118（48.76）	125（51.65）	109（45.04）	23.76±3.52
ACS组	262	55.28±14.21	116（44.27）	146（55.73）	129（49.24）	153（58.40）	135（51.53）	24.35±3.24
统计值		1.660	1.749		0.011	2.313	2.119	1.959
P值		0.097	0.080		0.914	0.128	0.145	0.051

组别	例数	年龄/岁	性别		吸烟史/ [例（%）]	糖尿病史/ [例（%）]	高血压史/ [例（%）]	体重指数/ （kg·m-2）
组别	例数	年龄/岁	男/[例（%）]	女/[例（%）]	吸烟史/ [例（%）]	糖尿病史/ [例（%）]	高血压史/ [例（%）]	体重指数/ （kg·m-2）
对照组	242	57.46±15.27	126（52.07）	116（47.93）	118（48.76）	125（51.65）	109（45.04）	23.76±3.52
ACS组	262	55.28±14.21	116（44.27）	146（55.73）	129（49.24）	153（58.40）	135（51.53）	24.35±3.24
统计值		1.660	1.749		0.011	2.313	2.119	1.959
P值		0.097	0.080		0.914	0.128	0.145	0.051

组别	例数	HDL-C/（mmol·L^-1）		LDL-C/（mmol·L^-1）		TG/（mmol·L^-1）		TC/（mmol·L^-1）	MAO/（U·L^-1）
对照组	242	1.27±0.29		2.45±0.46		2.19±0.62		3.46±0.78	1.86±0.42
ACS组	262	1.31±0.36		2.57±0.61		2.26±0.71		3.65±0.89	3.82±0.88
统计值		1.367		2.478		1.175		2.540	31.490
P值		0.172		0.014		0.241		0.011	<0.001
组别	cTnI/（μg·L^-1）		hs-CRP/（mg·L^-1）		FBG/（mmol·L^-1）		NT-proBNP/（ng·L^-1）
对照组	0.46±0.08		3.69±0.84		6.48±1.74		424.12（327.54，456.84）
ACS组	1.95±0.71		9.41±1.67		6.96±1.82		1 085.72（887.02，1 231.77）
统计值	32.450		47.970		3.021		-18.931
P值	<0.001		<0.001		0.003		<0.001

组别	例数	HDL-C/（mmol·L^-1）		LDL-C/（mmol·L^-1）		TG/（mmol·L^-1）		TC/（mmol·L^-1）	MAO/（U·L^-1）
对照组	242	1.27±0.29		2.45±0.46		2.19±0.62		3.46±0.78	1.86±0.42
ACS组	262	1.31±0.36		2.57±0.61		2.26±0.71		3.65±0.89	3.82±0.88
统计值		1.367		2.478		1.175		2.540	31.490
P值		0.172		0.014		0.241		0.011	<0.001
组别	cTnI/（μg·L^-1）		hs-CRP/（mg·L^-1）		FBG/（mmol·L^-1）		NT-proBNP/（ng·L^-1）
对照组	0.46±0.08		3.69±0.84		6.48±1.74		424.12（327.54，456.84）
ACS组	1.95±0.71		9.41±1.67		6.96±1.82		1 085.72（887.02，1 231.77）
统计值	32.450		47.970		3.021		-18.931
P值	<0.001		<0.001		0.003		<0.001

组别	例数	MAO/（U·L^-1）
对照组
男	126	1.68±0.43
女	116	1.72±0.41
t值		0.739
P值		0.461
ACS组
男	116	3.98±0.87
女	146	4.14±0.91
t值		1.441
P值		0.151