Mechanisms of cancer-associated thrombosis

doi:10.3969/j.issn.1673-8640.2025.02.016

Abstract

Abstract:

Malignant tumors are related to thrombosis，and cancer-associated thrombosisis mainly manifested as spontaneous intra-vascular coagulation activation. At present，thrombosis and its related complications have become the second leading cause of death in cancer patients，after the tumor itself. The mechanism of thrombosis in malignant tumors is complex，and there are differences among patients with different tumors and different stages of malignant tumor progression，which may be related to blood hypercoagulability，vascular wall injury and blood stasis. The 3 elements of thrombosis，namely abnormal blood flow，impaired vascular integrity and changes in blood composition，are all related to the high tendency of thrombosis in tumor patients. Some tumor diagnosis and treatment methods can also increase the occurrence of cancer-associated thrombosis. The risk of venous thromboembolism （VTE） can be increased several times in patients with tumors who have inherited or acquired thromboembolism factors. This review describes the main known mechanisms of cancer-associated thrombosis.

Key words: Cancer-associated thrombosis, Tissue factor, Platelet, Neutrophil extracellular trap net, Extracellular vesicle

CLC Number:

R446.7

LI Bo, XIA Yongquan, SHEN Ping, XIA Mao, ZENG Jiawei. Mechanisms of cancer-associated thrombosis[J]. Laboratory Medicine, 2025, 40(2): 192-196.

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