Influence of concomitant gene mutation on acute myeloid leukemia patients with RUNX1::RUNX1T1 fusion

doi:10.3969/j.issn.1673-8640.2025.02.015

Abstract

Abstract:

Acute myeloid leukemia（AML） with RUNX1::RUNX1T1 fusion is a common type of leukemia with unique clinical characteristics. Despite the good remission rates initially achieved with induction therapy，the recent studies have revealed significant heterogeneity in the prognosis of these patients. Particularly when AML with RUNX1::RUNX1T1 fusion is accompanied by other gene mutations，different mutations can influence the development and prognosis of the disease through various mechanisms. The presence of most gene mutations increases the relapse rate and decreases the long-term survival of these patient，which severely impacts their prognosis. This review summarizes the latest research progress on how different gene mutations affect the pathogenesis and prognosis of AML with RUNX1::RUNX1T1 fusion through various mechanisms.

Key words: RUNX1::RUNX1T1 fusion, Gene mutation, Acute myeloid leukemia, Prognosis

CLC Number:

R446.7

TANG Jiemei, WANG Binbin, LIU Na, TANG Gusheng. Influence of concomitant gene mutation on acute myeloid leukemia patients with RUNX1::RUNX1T1 fusion[J]. Laboratory Medicine, 2025, 40(2): 186-191.

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