Research progress on relationship between histone lactation and disease

doi:10.3969/j.issn.1673-8640.2024.07.015

Abstract

Abstract:

Histones are the main protein components of chromatin and play roles in the regulation of biological genetic information. As a common product of cell metabolism，lactic acid can affect the expression of cell genetic information. Under the action of related enzymes，histones can undergo chemical modifications of various groups，among which lactation is one of the important chemical modifications. This review mainly focuses on the occurrence and influencing factors of histone lactation，the relationship between histone lactation and common diseases and the research progress of treatment.

Key words: Histone, Lactic acid modification, Disease

CLC Number:

R446.1

KUANG Xiandong, CAI Xin, TANG Dongling, ZHANG Ping'an. Research progress on relationship between histone lactation and disease[J]. Laboratory Medicine, 2024, 39(7): 704-708.

Figures/Tables 2

References 30

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相关疾病	细胞	组蛋白乳酸化位点	参考文献
肺纤维化	巨噬细胞	精氨酸酶1	[4]
脓毒症	巨噬细胞	血小板衍生生长因子A	[5]
脓毒症	巨噬细胞	血小板反应蛋白	[5]
脓毒症	巨噬细胞	血管内皮生长因子A的近端启动子区	[5]
无	巨噬细胞	组蛋白H3K18	[6]
无	巨噬细胞	高迁移率族蛋白B1	[6]
肺动脉高压	巨噬细胞	组蛋白H4K5	[10]
恶性胸腔积液	自然杀伤细胞	叉状头转录因子P3 启动子前端	[7]
肝细胞癌	肝细胞	组蛋白ABCF1-K430	[3]
肝细胞癌	肺细胞	组蛋白ABCF1-K430	[3]
肺动脉高压	肺动脉平滑肌细胞	缺氧诱导因子1α	[10]
阿尔茨海默病	脑细胞	组蛋白H4K12	[8]
脑缺血	脑细胞	高迁移率族蛋白B1	[11]
前列腺癌	前列腺癌细胞	组蛋白H3K18	[9]
肺腺癌	肌细胞	组蛋白H3K18	[9]
无	原始胚胎神经元	组蛋白H1	[12]
无	胚胎成纤维细胞	组蛋白H3K18	[12]
眼黑色素瘤	黑色素瘤细胞	组蛋白H3K18	[12]
无	肺支气管上皮细胞	组蛋白H4K8	[12]

相关疾病	细胞	组蛋白乳酸化位点	参考文献
肺纤维化	巨噬细胞	精氨酸酶1	[4]
脓毒症	巨噬细胞	血小板衍生生长因子A	[5]
脓毒症	巨噬细胞	血小板反应蛋白	[5]
脓毒症	巨噬细胞	血管内皮生长因子A的近端启动子区	[5]
无	巨噬细胞	组蛋白H3K18	[6]
无	巨噬细胞	高迁移率族蛋白B1	[6]
肺动脉高压	巨噬细胞	组蛋白H4K5	[10]
恶性胸腔积液	自然杀伤细胞	叉状头转录因子P3 启动子前端	[7]
肝细胞癌	肝细胞	组蛋白ABCF1-K430	[3]
肝细胞癌	肺细胞	组蛋白ABCF1-K430	[3]
肺动脉高压	肺动脉平滑肌细胞	缺氧诱导因子1α	[10]
阿尔茨海默病	脑细胞	组蛋白H4K12	[8]
脑缺血	脑细胞	高迁移率族蛋白B1	[11]
前列腺癌	前列腺癌细胞	组蛋白H3K18	[9]
肺腺癌	肌细胞	组蛋白H3K18	[9]
无	原始胚胎神经元	组蛋白H1	[12]
无	胚胎成纤维细胞	组蛋白H3K18	[12]
眼黑色素瘤	黑色素瘤细胞	组蛋白H3K18	[12]
无	肺支气管上皮细胞	组蛋白H4K8	[12]