Influence of Helicobacter pylori infection on serum gastric function related indicators and peripheral blood inflammatory cells in different ages

doi:10.3969/j.issn.1673-8640.2021.010.014

Abstract

Abstract:

Objective To investigate the determination results of serum gastric function related indicators and peripheral blood inflammatory cells in different age patients with Helicobacter pylori（Hp） infection. Methods A total of 1 807 healthy subjects of different ages were enrolled and classified into <40-year-old group（1 273 cases） and ≥40-year-old group（534 cases）,and they were classified into Hp positive group and Hp negative group. Routine blood test,pepsinogen（PG） Ⅰ,PG Ⅱ,gastrin 17（G17） were determined. Results In Hp positive group,the proportion of males of ≥40-year-old was higher than that of females（P<0.05）. The white blood cell count,lymphocyte count and neutrophil count were lower in <40-year-old group than those in ≥40-year-old group（P<0.05）,but PG Ⅰ and G17 were higher（P<0.05）. In Hp negative group,white blood cell count,monocyte count,lymphocyte count and neutrophil count were lower in <40-year-old group than those in ≥40-year-old group（P<0.05）,but PG Ⅰ,PG Ⅱ and G17 were higher（P<0.05）. In ≥40-year-old group,white blood cell count,lymphocyte count,PG Ⅰ,PG Ⅱ and G17 were higher in Hp positive group than those in Hp negative group,but PGⅠ/PGⅡ was lower（P<0.05）. In the <40-year-old group,white blood cell count,neutrophil count,PG Ⅰ,PG Ⅱ and G17 were higher in Hp positive group than those in Hp negative group（P<0.05）,and PGⅠ/PGⅡ was lower（P<0.05）. Pearson correlation analysis results showed that white blood cell count,neutrophil count,PG Ⅰ,PG Ⅱ and G17 were positively related to Hp infection in <40-year-old group（r values were 0.075,0.064,0.286,0.396 and 0.323,P<0.05）,and PGⅠ/PGⅡ was negatively correlated with Hp infection（r=-0.213,P<0.05）. White blood cell count,lymphocyte count,PG Ⅰ,PG Ⅱ and G17 were positively related to Hp infection in ≥40-year-old group（r values were 0.121,0.111,0.203,0.316 and 0.126,P<0.05）,and PGⅠ/PGⅡ was negatively correlated with Hp infection（r=-0.253,P<0.05）. Multivariate linear regression analysis results showed that PG Ⅱ and G17 had statistical significance in <40-year-old group（P<0.05）,and PG Ⅱ,white blood cell count and PGⅠ/PGⅡ had statistical significance in ≥40-year-old group（P<0.05）. Conclusions The levels of serum gastric function related indicators and peripheral blood inflammatory cells are different in different age patients with Hp infection,which can provide a reference for early screening of gastric cancer.

Key words: Pepsinogen, Gastrin 17, Helicobacter pylori, Peripheral blood inflammatory cell

CLC Number:

R446.1

WANG Yanhong, PANG Xunlei, SHEN Guifang, LI Li, FEI Sujuan. Influence of Helicobacter pylori infection on serum gastric function related indicators and peripheral blood inflammatory cells in different ages[J]. Laboratory Medicine, 2021, 36(10): 1055-1059.

Figures/Tables 3

References 17

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年龄	例数	性别		Hp阳性	Hp阴性
年龄	例数	男性	女性	Hp阳性	Hp阴性
<40岁	1 273	634（49.80）	639（50.20）	663（52.08）	610（47.92）
≥40岁	534	246（46.07）	288（53.93）	339（63.48）	195（37.52）
χ²值		1.222		21.477
P值		0.269		<0.001

年龄	例数	性别		Hp阳性	Hp阴性
年龄	例数	男性	女性	Hp阳性	Hp阴性
<40岁	1 273	634（49.80）	639（50.20）	663（52.08）	610（47.92）
≥40岁	534	246（46.07）	288（53.93）	339（63.48）	195（37.52）
χ²值		1.222		21.477
P值		0.269		<0.001

组别	例数	白细胞计数/ （×10⁹/L）	单核细胞计数/ （×10⁹/L）	淋巴细胞计数/ （×10⁹/L）	中性粒细胞计数/ （×10⁹/L）
Hp阳性组
<40岁	663	6.48±1.50	0.34±0.10	2.30±0.57	3.70±1.23
≥40岁	339	6.16±1.45^**	0.33±0.11	2.16±0.58^**	3.50±1.09^*
P值		0.002	0.105	0.001	0.014
Hp阴性组
<40岁	610	6.25±1.47^##	0.34±0.10	2.24±0.56	3.54±1.19^##
≥40岁	195	5.82±1.24^***△△	0.32±0.10^**	2.03±0.56^***△	3.33±0.99^*
P值	<0.001	0.007	<0.001	0.010
组别		PGⅠ/（μg/L）	PGⅡ/（μg/L）	PGⅠ/P GⅡ比值	G17/（pmol/L）
Hp阳性组
<40岁		139.84 （106.26~182.99）	12.66 （7.98~19.38）	11.54 （8.53~15.14）	5.43 （2.10~11.57）
≥40岁		152.79 （120.36~197.85）^**	14.02 （8.32~19.82）	11.20 （8.83~14.62）	4.41 （1.37~8.65）^**
Hp阴性组
<40岁		112.75 （91.70~135.85）^###	7.15 （5.55~9.93）^###	15.22 （12.27~19.32）^###	1.16 （0.62~2.39）^###
≥40岁		128.59 （103.27~158.75）^***△△△	8.42 （6.22~11.15）^***△△△	15.36 （11.61~19.96）^△△△	1.56 （0.79~3.03）^**△△

组别	例数	白细胞计数/ （×10⁹/L）	单核细胞计数/ （×10⁹/L）	淋巴细胞计数/ （×10⁹/L）	中性粒细胞计数/ （×10⁹/L）
Hp阳性组
<40岁	663	6.48±1.50	0.34±0.10	2.30±0.57	3.70±1.23
≥40岁	339	6.16±1.45^**	0.33±0.11	2.16±0.58^**	3.50±1.09^*
P值		0.002	0.105	0.001	0.014
Hp阴性组
<40岁	610	6.25±1.47^##	0.34±0.10	2.24±0.56	3.54±1.19^##
≥40岁	195	5.82±1.24^***△△	0.32±0.10^**	2.03±0.56^***△	3.33±0.99^*
P值	<0.001	0.007	<0.001	0.010
组别		PGⅠ/（μg/L）	PGⅡ/（μg/L）	PGⅠ/P GⅡ比值	G17/（pmol/L）
Hp阳性组
<40岁		139.84 （106.26~182.99）	12.66 （7.98~19.38）	11.54 （8.53~15.14）	5.43 （2.10~11.57）
≥40岁		152.79 （120.36~197.85）^**	14.02 （8.32~19.82）	11.20 （8.83~14.62）	4.41 （1.37~8.65）^**
Hp阴性组
<40岁		112.75 （91.70~135.85）^###	7.15 （5.55~9.93）^###	15.22 （12.27~19.32）^###	1.16 （0.62~2.39）^###
≥40岁		128.59 （103.27~158.75）^***△△△	8.42 （6.22~11.15）^***△△△	15.36 （11.61~19.96）^△△△	1.56 （0.79~3.03）^**△△

项目	β值	标准误	β'值	t值	P值
<40岁
白细胞计数	0.022	0.021	0.067	1.075	0.283
中性粒细胞计数	-0.012	0.025	-0.029	-0.472	0.637
PGⅠ	0.001	0.000	0.058	1.504	0.133
PGⅡ	0.020	0.002	0.316	10.32	<0.001
PGⅠ/PGⅡ比值	-0.003	0.002	-0.045	-1.382	0.167
G17	0.008	0.002	0.149	4.889	<0.001
≥40岁
白细胞计数	0.034	0.015	0.094	2.285	0.023
淋巴细胞计数	0.032	0.044	0.037	0.735	0.463
PGⅠ	0.000	0.001	0.047	0.685	0.494
PGⅡ	0.014	0.003	0.241	4.702	<0.001
PGⅠ/PGⅡ比值	0.008	0.004	–0.108	–2.115	0.035
G17	0.000	0.002	–0.004	–0.097	0.922