Role of serum lipid transfer protein activity determination in patients with hypothyroidism

doi:10.3969/j.issn.1673-8640.2019.10.011

Abstract

Abstract: Objective To investigate the role of serum lipid transfer protein activity determination in patients with hypothyroidism. Methods A total of 86 patients with hypothyroidism and 86 healthy subjects were enrolled. The general data [sex,age,smoking history,drinking history and body mass index（BMI）] were collected. Total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C） and non-high-density lipoprotein cholesterol（non-HDL-C） levels and serum cholesterol ester transporter（CETP） and phospholipid transporter（PLTP） activities were determined. Multiple linear regression analysis was used to evaluate the relationship of hypothyroidism with blood lipids and lipid transfer proteins. Results Compared with healthy control group,serum HDL2-C level,HDL2-C/HDL3-C ratio,CETP activity and PLTP activity decreased（P<0.01）,HDL3-C level increased（P<0.01）,and there was no statistical significance in serum TC,TG,LDL-C,HDL-C and non-HDL-C between the 2 groups（P>0.05）. CETP was positively correlated with HDL2-C（r=0.27,P<0.001）,and it was negatively correlated with HDL3-C and thyroid stimulating hormone（TSH）（r=-0.22 and -0.21,P<0.01）. PLTP was positively correlated with HDL2-C（r=0.37,P<0.001）,and it was negatively correlated with HDL3-C and TSH（r=-0.24,P<0.001）. There was no correlation of TSH with HDL2-C and HDL3-C（r=-0.291 and 0.012,P>0.05）. Multiple linear regression analysis after adjusting for age,sex,BMI,smoking history and drinking history showed that CETP and PLTP were correlated with hypothyroidism（β=0.62 and 0.81,P<0.001）,and they were not correlated with blood lipids（P>0.05）. Conclusions The decrease of HDL2-C and the increase of HDL3-C in patients with hypothyroidism are related to the decrease of lipid transfer protein activity. These may be early biomarkers of lipid disorders in patients with hypothyroidism.

Key words: Cholesterol ester transporter, Phospholipid transporter, Thyroid stimulating hormone, Hypothyroidism

CLC Number:

R446.1

DU Feifei, MA Yue, WANG Ni. Role of serum lipid transfer protein activity determination in patients with hypothyroidism[J]. Laboratory Medicine, 2019, 34(10): 913-917.

Figures/Tables 4

References 18

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组别	例数	年龄（岁）	性别		BMI（kg/m²）	吸烟史 [例（%）]	饮酒史 [例（%）]
组别	例数	年龄（岁）	男（例）	女（例）	BMI（kg/m²）	吸烟史 [例（%）]	饮酒史 [例（%）]
甲减组	86	48.1±3.6	14	72	25.1（21.3~29.4）	6（5.94）	5（4.95）
正常对照组	86	47.9±3.3	14	72	25.7（22.8~29.6）	6（5.94）	5（4.95）

组别	例数	年龄（岁）	性别		BMI（kg/m²）	吸烟史 [例（%）]	饮酒史 [例（%）]
组别	例数	年龄（岁）	男（例）	女（例）	BMI（kg/m²）	吸烟史 [例（%）]	饮酒史 [例（%）]
甲减组	86	48.1±3.6	14	72	25.1（21.3~29.4）	6（5.94）	5（4.95）
正常对照组	86	47.9±3.3	14	72	25.7（22.8~29.6）	6（5.94）	5（4.95）

组别	例数	TSH（μIU/mL）	FT₃（pg/mL）	TT₃（ng/mL）	FT₄（pg/mL）	TT₄（ng/mL）
甲减组	86	5.08 （4.32~6.73）^*	4.39 （4.03~4.71）	2.49 （1.89~2.67）	7.12 （6.31~8.16）^*	43.29 （31.33~55.42）^**
正常对照组	86	1.62 （1.01~2.17）	4.37 （4.05~4.82）	2.41 （1.87~2.69）	10.20 （10.09~13.14）	106.98 （94.36~116.46）

组别	例数	TSH（μIU/mL）	FT₃（pg/mL）	TT₃（ng/mL）	FT₄（pg/mL）	TT₄（ng/mL）
甲减组	86	5.08 （4.32~6.73）^*	4.39 （4.03~4.71）	2.49 （1.89~2.67）	7.12 （6.31~8.16）^*	43.29 （31.33~55.42）^**
正常对照组	86	1.62 （1.01~2.17）	4.37 （4.05~4.82）	2.41 （1.87~2.69）	10.20 （10.09~13.14）	106.98 （94.36~116.46）

组别	例数	TC（mmol/L）	TG（mmol/L）	LDL-C（mmol/L）	HDL-C（mmol/L）	non-HDL-C（mmol/L）
甲减组	86	1.40±0.56	5.62±1.16	3.33±1.33	1.49±0.36	4.13±1.11
正常对照组	86	1.50±0.81	5.66±1.16	3.40±1.02	1.58±0.39	4.08±1.18
组别	HDL2-C （mmol/L）		HDL3-C （mmol/L）	HDL2-C/HDL3-C 比值	CETP [nmol/（mL·h）]	PLTP [nmol/（mL·h）]
甲减组	0.35±0.19^*		1.06±0.28^*	0.41±0.15^*	35.35±12.00^*	37.25±11.10^*
正常对照组	0.65±0.33		0.92±0.18	0.73±0.38	59.70±13.59	77.24±18.85