Abstract:

Objective To evaluate the results of prenatal screening for pregnant women in Shanghai,including the indices of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, hepatitis B surface antigen （HBsAg）, anti-hepatitis C virus （HCV） antibody, anti-human immunodeficiency virus （HIV） antibody and anti-treponema pallidum （TP） antibody. Methodse The levels of ALT, AST, HBsAg,anti-HCV antibody,anti-HIV antibody and anti-TP antibody were determined in 63 109 pregnant women from 2013 to 2016. Results The positive rates of HBsAg,anti-TP antibody,ALT and AST were higher in >35-year-old group than those in ≤35-year-old group （P<0.01）. There was no statistical significance for the positive rate of anti-HCV antibody between the 2 groups （P>0.05）. The positive rate of HBsAg had a decreasing trend from 2013 to 2016 （P<0.05）. The positive rate of anti-TP antibody had an increasing trend （P<0.05）,and there was no statistical significance for the other indices from 2013 to 2016 （P>0.05）. The women with abnormal pregnancy history had a higher positive rate of anti-TP antibody compared with healthy pregnant women （P<0.01）,and other indices had no statistical significance between the 2 groups（P>0.05）. Conclusions Prenatal screening may contribute to understand the prevalence of diseases in pregnant women,which is beneficial for good prenatal and postnatal care.

Key words: Alanine aminotransferase, Aspartate aminotransferase, Hepatitis B surface antigen, Hepatitis C virus, Human immunodeficiency virus, Treponema pallidum, Prenatal screening