Changes and clinical significance of IP-10 for antiviral therapy in AIDS patients

doi:10.3969/j.issn.1673-8640.2022.03.006

Abstract

Abstract:

Objective To investigate the changes and clinical significance of interferon-inducible protein-10（IP-10） for antiviral therapy in acquired immunodeficiency syndrome（AIDS） patients. Methods Totally,200 AIDS patients（AIDS group） receiving highly active antiroviral therapy（HAART） were enrolled and classified into HIV-1 inhibition group and HIV-1 non-inhibition group according to curative effect. The percentage of CD4⁺ T cells,the percentage of CD8⁺ T cells,the virus load of human immunodeficiency virus（HIV）-1 and the level of IP-10 were determined before treatment and at 2 weeks,1 month,2 months,3 months,6 months,12 months and 18 months after treatment. A total of 100 healthy subjects were enrolled as healthy control group. Spearman correlation analysis was used to evaluate the correlation between IP-10 and the other indicators. Results The level of HIV-1 RNA in AIDS group before treatment was（4.62±0.73） lg copies/mL. The percentage of CD4⁺ T cells in AIDS group was lower than that in healthy control group（P<0.01）. The level of IP-10 and the percentage of CD8⁺ T cells were higher than those in healthy control group（P<0.01）. Compared with those before treatment,with the extension of treatment time,the percentage of CD4⁺ T cells increased gradually（P<0.01）,the percentage of CD8⁺ T cells and the levels of IP-10 and HIV-1 RNA decreased gradually（P<0.01）,and the proportion of patients with inhibited HIV-1 replication increased gradually（P<0.01）. At 3,6,12 and 18 months of treatment,the percentage of CD4⁺ T cells in HIV-1 inhibition group was higher than that in HIV-1 non-inhibition group（P<0.01）,and the percentage of CD8⁺ T cells and IP-10 level were lower than those in HIV-1 non-inhibition group（P<0.01）. Spearman correlation analysis showed that the level of IP-10 in AIDS patients was negatively correlated with the percentage of CD4⁺ T cells（r=-0.763,P<0.05）,and it was positively correlated with the percentage of CD8⁺ T cells and the level of HIV-1 RNA（r=0.801,P<0.05;r=0.823,P<0.05）. Conclusions The level of IP-10 in AIDS patients is related to the levels of CD4⁺ T cells,CD8⁺ T cells and HIV-1 RNA. It is an indicator of potential AIDS and efficacy evaluation.

Key words: Interferon-inducible protein-10, Human immunodeficiency virus, Highly active antiroviral therapy, Acquired immunodeficiency syndrome

CLC Number:

R446.1

FAN Weiguang, SU Miaomiao, MENG Juan, SHI Penghui, ZHANG Zhen. Changes and clinical significance of IP-10 for antiviral therapy in AIDS patients[J]. Laboratory Medicine, 2022, 37(3): 221-225.

Figures/Tables 3

References 21

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组别	例数	CD4⁺T细胞/%	CD8⁺T细胞/%	IP-10/（pg/mL）
AIDS组	200	25.25±3.26	34.27±4.12	1 786.25±257.61
正常对照组	100	43.86±4.62	17.64±1.45	85.17±35.47
t值		36.005	41.496	65.669
P值		<0.001	<0.001	<0.001

组别	例数	CD4⁺T细胞/%	CD8⁺T细胞/%	IP-10/（pg/mL）
AIDS组	200	25.25±3.26	34.27±4.12	1 786.25±257.61
正常对照组	100	43.86±4.62	17.64±1.45	85.17±35.47
t值		36.005	41.496	65.669
P值		<0.001	<0.001	<0.001

时间点	CD4⁺T细胞/%	CD8⁺T细胞/%	IP-10/（pg/mL）	HIV-1 RNA/（lg拷贝/mL）	HIV-1抑制/[例（%）]
治疗前	25.25±3.26	34.57±4.12	1 786.25±257.61	4.62±0.73	0（0）
治疗后
2周	26.47±3.35^*	33.23±4.25^*	1 427.85±227.35^*	3.45±0.42^*	5（2.50）
1个月	27.82±3.41^*	32.84±3.96^*	1 294.57±196.47^*	2.94±0.37^*	16（8.00）
2个月	28.64±3.52^*	30.45±3.83^*	1 137.39±157.40^*	2.64±0.32^*	31（15.50）^*
3个月	29.12±3.63^*	29.49±3.69^*	967.39±125.67^*	2.34±0.17^*	107（53.50）^*
6个月	30.47±3.92^*	28.65±3.15^*	829.45±84.63^*	1.84±0.15^*	161（80.50）^*
12个月	31.84±4.32^*	26.14±2.75^*	653.52±47.38^*	1.12±0.11^*	185（92.50）^*
18个月	33.27±4.27^*	25.47±2.64^*	526.28±42.74^*	0.84±0.08^*	191（95.50）^*

时间点	CD4⁺T细胞/%	CD8⁺T细胞/%	IP-10/（pg/mL）	HIV-1 RNA/（lg拷贝/mL）	HIV-1抑制/[例（%）]
治疗前	25.25±3.26	34.57±4.12	1 786.25±257.61	4.62±0.73	0（0）
治疗后
2周	26.47±3.35^*	33.23±4.25^*	1 427.85±227.35^*	3.45±0.42^*	5（2.50）
1个月	27.82±3.41^*	32.84±3.96^*	1 294.57±196.47^*	2.94±0.37^*	16（8.00）
2个月	28.64±3.52^*	30.45±3.83^*	1 137.39±157.40^*	2.64±0.32^*	31（15.50）^*
3个月	29.12±3.63^*	29.49±3.69^*	967.39±125.67^*	2.34±0.17^*	107（53.50）^*
6个月	30.47±3.92^*	28.65±3.15^*	829.45±84.63^*	1.84±0.15^*	161（80.50）^*
12个月	31.84±4.32^*	26.14±2.75^*	653.52±47.38^*	1.12±0.11^*	185（92.50）^*
18个月	33.27±4.27^*	25.47±2.64^*	526.28±42.74^*	0.84±0.08^*	191（95.50）^*

时间点	例数	CD4⁺T细胞/%	CD8⁺T细胞/%	IP-10/（pg/mL）
治疗后3个月
HIV-1抑制组	107	33.35±4.15	26.57±3.17	816.98±96.54
HIV-1未抑制组	93	27.82±3.52	30.39±3.20	1 013.58±124.37
t值		9.020	7.174	9.949
P值		<0.001	<0.001	<0.001
治疗后6个月
HIV-1抑制组	161	32.72±3.96	27.13±3.22	729.14±82.35
HIV-1未抑制组	39	24.17±2.87	34.95±3.41	1 243.34±134.26
t值		12.690	13.452	30.472
P值		<0.001	<0.001	<0.001
治疗后12个月
HIV-1抑制组	185	32.37±3.75	25.53±3.13	608.01±74.36
HIV-1未抑制组	15	25.32±2.94	33.67±3.17	1 214.86±126.52
t值		7.100	9.678	28.547
P值		<0.001	<0.001	<0.001
治疗后18个月
HIV-1抑制组	191	33.68±3.42	25.18±3.15	492.97±58.64
HIV-1未抑制组	9	24.55±3.05	31.71±3.25	1 231.35±131.47
t值		7.859	6.070	34.236
P值		<0.001	<0.001	<0.001