Research progress on immune factors related with HIV infectious disease development

doi:10.3969/j.issn.1673-8640.2015.06.024

Abstract

Abstract:

Host immune response is one of important factors that determines the progress of human immunodeficiency virus (HIV) infectious diseases. Different immunocytes or immune factors might play different roles, or even work oppositely, when the disease develops. So far, key factors affecting HIV infectious disease development clinical outcome are still unclear. This review gives an overview to the hot research in this field.

Key words: Human immunodeficiency virus, Infection, Immune, Disease progression

CLC Number:

R373.9

WEI Shanqiu. Research progress on immune factors related with HIV infectious disease development[J]. Laboratory Medicine, 2015, 30(6): 646-649.

References 25

[1]	WIJEWARDANA V,SOLOFF AC,LIU X, et al.Early myeloid dendritic cell dysregulation is predictive of disease progression in simian immunodeficiency virus infection[J].PLoS Pathog,2010,6(12):e1001235.
[2]	陈军. HIV感染中髓样树突状细胞数量减少的机制及功能改变研究[D].上海:复旦大学,2012.
[3]	GENG W,FAN X,DIAO Y,et al.Rapid disease pro-gression in HIV-1-infected men who have sex with men is negatively correlated with peripheral plasmacytoid dendritic cell counts at the early stage of primary infection[J].J Clin Immunol,2011,31(5):882-890.
[4]	张美,焦艳梅,张宏伟,等.慢性HIV感染者抗逆转录病毒治疗过程中树突状细胞亚群的变化特点[J].中华微生物学和免疫学杂志,2012,32(4):363-368.
[5]	HAN J,WANG B,HAN N,et al.CD14(high)CD16(+)rather than CD14(low)CD16(+) monocytes correlate with disease progression in chronic HIV-infected patients[J].J Acquir Immune Defic Syndr,2009,52(5):553-559.
[6]	WILLIAMS DW,EUGENIN EA,CALDERON TM,et al.Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis[J].J Leukoc Biol,2012,91(3):401-415.
[7]	罗玲. 单核细胞激活标志物与HIV/AIDS患者动脉粥样硬化的关系[D]. 北京: 北京协和医院,2012.
[8]	梁华,赵阳阳,李丹,等.早期HIV-1感染者单核细胞对TLR配体反应性研究[J].中华微生物学和免疫学杂志,2014,34(5):354-358.
[9]	年华,耿文清,崔华露,等.单核细胞TLR7/8表达与HIV-1感染疾病进程关系的研究[J].中华微生物和免疫学杂志,2009,29(11):992-996.
[10]	赵雪. HIV感染者NK细胞功能及亚群变化研究[D].辽宁:中国医科大学,2013.
[11]	张子宁,刘静,张旻,等. HIV/AIDS患者 CD4+ CD25+ Foxp3+ CD45RO+记忆性调节T细胞变化研究[J].中国免疫学杂志,2013,29(11):1168-1173.
[12]	姚运海. IFN-γ对HAART治疗1年HIV/AIDS患者免疫重建的影响[D].湖南:中南大学,2013.
	[13 ] ZHANG Z,JIANG Y,ZHANG M,et al.Alterations of CD4(+)CD25(+)Foxp3(+) regulatory T cells in HIV-infected slow progressors of former blood donors in China[J].Microbiol Immunol,2010,54(10):625-633.
[14]	张宏伟,邱志峰,李太生.HⅣ感染长期不进展者与艾滋病患者HIV-1 gag特异性CD8+T细胞应答[J].中华内科杂志,2004,43(12):911-914.
[15]	张宏伟,邱志峰,李太生.长期不进展者与艾滋病患者HIV-1 nef特异性CD8+T细胞应答的初步研究[J].中华医学杂志,2004,84(23):1973-1976.
[16]	吴鹏. 中国HIV感染长期不进展者与典型进展者遗传、免疫及HIV变异特点研究[D]. 北京:北京大学,2011.
[17]	潘莹,耿文清,崔华露,等.HIV-1感染疾病缓慢进展者CD8+T淋巴细胞非细胞毒性免疫应答作用的研究[J].中华微生物学和免疫学杂志,2010,30(5):456-459.
[18]	WANG F,JIN L,LEI Z,et al.Genotypes and polymorphisms of mutant CCR5-delta 32,CCR2-64I and SDFl-3'A HIV-1 resistance alleles in indigenous Han Chinese[J].Chin Med J(Engl),2001,114(11):1162-1166.
[19]	REICHE EM,EHARA WATANABE MA, BONAMETTI AM,et al.The effect of stromal cell-derived factor 1(SDF1/CXCL12)genetic polymorphism on HIV-1 disease progression[J]. Int J Mol Med,2006,18(4):785-793.
[20]	BURTON CT,GOTCH FM,IMAMI N.CCR2/64I mutation detection in a HIV-1-positive patient with slow CD4 T-cell decline and delay in disease progression[J].Int J STD AIDS,2005,16(5):392-394.
[21]	钱源. 与HIV-1感染相关的基因在中国20个民族群体中的多态性研究[D]. 北京:北京大学,2008.
[22]	贺小峰. CCR5△32、SDFl-3’A and CCR2-641基因的多态性与HIV-1感染相关性的Meta分析[D].广东:南方医科大学,2011.
[23]	KARPAS A,HILL F,YOULE M,et al.Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome[J].Proc Natl Acad Sci USA,1988,85(23):9234-9237.
[24]	王倩,尚红,张子宁,等. 中国HIV-1感染人群中和抗体水平与疾病进展关系研究[J].中华微生物学和免疫学杂志,2006,26(10):894-897.
[25]	EULER Z,VAN GILS MJ,BUNNIK E M,et al.Cross-reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression[J].J Infect Dis,2010,201(7):1045-1053.

[1]	WANG Yangshuyi, YE WEI, LIN Zhihao, HUANG Yuenuo, FANG Tao, DONG Xiaoting. Construction and validation of a model for pyroptosis-related features in lung adenocarcinoma [J]. Laboratory Medicine, 2023, 38(9): 833-841.
[2]	WANG Huiying, TANG Yu, DONG Lili, WANG Jing. Role of Mycoplasma pneumoniae RNA determination in diagnosis and efficacy monitoring of pneumonia in children [J]. Laboratory Medicine, 2023, 38(9): 865-869.
[3]	ZHAO Jing, LI Yongqin, LI Yan, FAN Weiguang, YANG Xuegang. Roles of IP-10，SAA，hs-CRP，PCT and CD4⁺ T cell count determinations in HIV/AIDS patients with opportunistic infection [J]. Laboratory Medicine, 2023, 38(8): 725-729.
[4]	ZHANG Na, NIU Weihua, SUN Yuanyuan, JIA Mei. CMV and EBV co-infection affecting patient prognosis after hematopoietic stem cell transplantation [J]. Laboratory Medicine, 2023, 38(8): 760-765.
[5]	WANG Chao, ZHAO Yu. Research progress on formation mechanism and eradication strategy of bacterial persisters [J]. Laboratory Medicine, 2023, 38(8): 790-795.
[6]	CHEN Danyang, ZHENG Siyu, ZHENG Ruilin, SU Jingyao, ZHU Bing, LI Yinghua. Research progress in influenza viruses [J]. Laboratory Medicine, 2023, 38(7): 696-703.
[7]	REN Huirong, XU Tingjuan, WU Tao, HUANG Mei, YANG Liang. Role of serum progranulin in type Ⅰ autoimmune hepatitis prognosis evaluation [J]. Laboratory Medicine, 2023, 38(3): 245-250.
[8]	REN Yanfei, ZHANG Min, YANG Tao, LI Rongkai, LIANG Xin. Analysis of pathogenic epidemiology of patients with lower respiratory tract infection in respiratory intensive care unit [J]. Laboratory Medicine, 2023, 38(2): 157-162.
[9]	WANG Dongjiang, GUO Jian. Advance in laboratory diagnosis of invasive fungal infection [J]. Laboratory Medicine, 2023, 38(2): 179-185.
[10]	ZHOU Ying, REN Yihui, LI Guangming. Serum miR-148a expression in children with autoimmune hepatitis and its correlation with inflammatory factors [J]. Laboratory Medicine, 2023, 38(12): 1130-1134.
[11]	DAI Fangfang, LU Xinxin, YU Yanhua, CHEN Ming, SUN Guizhen. Analysis of Mycobacterium infection in HIV/AIDS patients [J]. Laboratory Medicine, 2023, 38(12): 1173-1176.
[12]	LU Xinli, LIU Yong, LI Yan, WANG Yingying, AN Ning, LIU Meng. Identification of near full-length genome structures of new HIV-1 recombinant strains [J]. Laboratory Medicine, 2023, 38(11): 1015-1019.
[13]	GU Yi, WANG Rui, DENG Jie, YANG Yijing, ZHOU Wangke, CHEN Yunuo, CHEN Xiaosong, SHEN Wei, ZHOU Jingyi. Differential analysis and prognostic diagnostic value of inflammatory biomarkers in liver transplantation in patients with severe hepatitis and cirrhosis [J]. Laboratory Medicine, 2023, 38(11): 1044-1051.
[14]	LU Qiyuan, LU Jianhua. Biomarker research progress for the diagnosis of periprosthetic joint infection [J]. Laboratory Medicine, 2023, 38(10): 997-1002.
[15]	LI Daming, LÜ Xing, JIANG Chuanhao, HU Min. Clinical application of gene chip technology for determining respiratory pathogens rapialy in pulmonary infection patients after renal transplantation [J]. Laboratory Medicine, 2022, 37(9): 864-867.