Receiver operating characteristic curve for free fatty acid determination in patients with coronary heart disease

doi:10.3969/j.issn.1673-8640.2017.05.004

Abstract

Abstract:

Objective To investigate the correlation of free fatty acid （FFA）with coronary heart disease （CHD）. Methodse A total of 110 patients with CHD,71 disease controls and 50 healthy subjects（healthy control group） were enrolled. Serum FFA,homocysteine（Hcy）,triglyceride（TG）,total cholesterol（TC） and lipoprotein（a）[Lp（a）] levels were determined. Receiver operating characteristic（ROC）curve was used to evaluate the diagnosis performance of each index. Results FFA,Hcy,TG and Lp（a）levels in CHD group were higher than those in healthy control group（P<0.01） and disease control group（P<0.05,P<0.01）,those in disease control group were higher than those in healthy control group （P<0.01）. TC had no statistical significance among the 3 groups （P>0.05）. The optimal cut-off value of FFA for the diagnosis of CHD was 596.20 μmol/L,the area under ROC curve was 0.924,the sensitivity was 85.5%,and the specificity was 90.1%. The diagnosis performance of FFA was superior to those of Hcy,TG,Lp（a） and TC. Conclusions FFA plays a role in the diagnosis of CHD.

Key words: Free fatty acid, Coronary heart disease, Homocysteine, Blood lipid

CLC Number:

R446.1

GU Keping, WANG Yaping, YU Wei, ZHANG Min, GONG Mengjiao, JIANG Yuhai. Receiver operating characteristic curve for free fatty acid determination in patients with coronary heart disease[J]. Laboratory Medicine, 2017, 32(5): 367-369.

Figures/Tables 3

References 10

[1]	马会利,胡桃红,邹建宏,等. 国人男女冠心病发病危险因素分析[J]. 心血管康复医学杂志,2011,20(6):517-519.
[2]	李斌,余绮玲,钟向红. 2型糖尿病伴冠心病患者胰岛素抵抗与游离脂肪酸关系研究[J]. 临床荟萃,2008,23(1):13-15.
[3]	郝亚平,马晓静,周密,等. 血清游离脂肪酸水平与冠状动脉病变的相关性[J]. 复旦学报(医学版),2012,39(5):465-469.
[4]	邵俊良,孙剑,韦勇,等. 冠心病患者血清同型半胱氨酸和脂蛋白a联合检测的临床意义[J]. 国际检验医学杂志,2015,36(2):255-256.
[5]	CUI Z,ZHONG S,XU P,et al.PANDA:a pipeline toolbox for analyzing brain diffusion images[J]. Front Hum Neurosci,2013,7:42.
[6]	张岩,陈晓亭,宋惠珠,等. 肥胖所导致的胰岛素抵抗分子机制的研究进展[J]. 检验医学,2014,29(7):774-778.
[7]	陈效琴,任静. 游离脂肪酸、胰岛素抵抗与代谢综合征相关因素的关系[J]. 检验医学,2016,31(7):553-558.
[8]	袁云龙,吴嘉,宋佳希,等. 冠心病患者血清游离脂肪酸、氧化脂蛋白(a)与冠状动脉病变程度的关系[J]. 临床检验杂志,2015,33(2):99-103.
[9]	GHASSIBE-SABBAGH M,PLATT D E,YOUHANNA S,et a1.Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk[J].Atherosclerosis,2012,222(1):180-186.
[10]	常志红,杨志明. 脂蛋白(a)和TG/HDL-C比值与冠心病的相关性研究[J]. 长治医学院学报,2014,28(1):43-45.

组别	例数	FFA（μmol/L）	Hcy（μmol/L）	TG（mmol/L）	TC（mmol/L）	Lp（a）（mg/L）
CHD组	110	954.41±400.52^*##	15.1（11.8~21.2）^*##	1.78（1.09~2.74）^*##	4.28±1.20	151.10（93.00~273.90）^*#
疾病对照组	50	238.97±134.07	7.30（6.30~8.93）	0.90（0.73~1.07）	4.28±0.51	48.65（31.65~85.23）
正常对照组	71	403.12±167.67^*	11.80（10.30~14.90）	1.23（0.89~1.85）^*	4.16±0.88	100.60（71.60~205.70）^*

组别	例数	FFA（μmol/L）	Hcy（μmol/L）	TG（mmol/L）	TC（mmol/L）	Lp（a）（mg/L）
CHD组	110	954.41±400.52^*##	15.1（11.8~21.2）^*##	1.78（1.09~2.74）^*##	4.28±1.20	151.10（93.00~273.90）^*#
疾病对照组	50	238.97±134.07	7.30（6.30~8.93）	0.90（0.73~1.07）	4.28±0.51	48.65（31.65~85.23）
正常对照组	71	403.12±167.67^*	11.80（10.30~14.90）	1.23（0.89~1.85）^*	4.16±0.88	100.60（71.60~205.70）^*

项目	敏感性（%）	特异性（%）	最佳临界值	标准误	ROC曲线下面积	95%可信区间
FFA	85.5	90.1	596.20 μmol/L	0.019	0.924	0.887~0.960
Hcy	66.4	59.2	13.25 μmol/L	0.039	0.693	0.617~0.769
TG	22.7	93.0	2.96 mmol/L	0.042	0.636	0.554~0.718
TC	37.3	73.2	4.50 mmol/L	0.044	0.531	0.445~0.616
Lp（a）	64.5	60.6	122.95 mg/L	0.043	0.603	0.519~0.688

项目	敏感性（%）	特异性（%）	最佳临界值	标准误	ROC曲线下面积	95%可信区间
FFA	85.5	90.1	596.20 μmol/L	0.019	0.924	0.887~0.960
Hcy	66.4	59.2	13.25 μmol/L	0.039	0.693	0.617~0.769
TG	22.7	93.0	2.96 mmol/L	0.042	0.636	0.554~0.718
TC	37.3	73.2	4.50 mmol/L	0.044	0.531	0.445~0.616
Lp（a）	64.5	60.6	122.95 mg/L	0.043	0.603	0.519~0.688

[1]	MA Jianguo, LI Hongchun. Correlation between blood lipid levels and cardiac function indexes in patients with coronary heart disease [J]. Laboratory Medicine, 2023, 38(7): 659-664.
[2]	JIN Suli, ZHAO Jing, ZHANG Jie, HOU Xuening, FANG Yanchao, YANG Li, MI Yujing. Relationship between thyroid hormones and bile acid subfractions and blood lipids in Graves' disease patients [J]. Laboratory Medicine, 2023, 38(6): 563-568.
[3]	WU Youhong, SONG Yunxiao, ZHU Yong, GE Wen, BIAN Xiaobo, YUAN Wenhua, ZHAO Zhiyun. Role of blood lipid levels in assessment of coronary artery stenosis and its treatment in patients with coronary heart disease [J]. Laboratory Medicine, 2023, 38(6): 584-589.
[4]	ZHENG Zhiyou, LI Xingzhao, XIE Yage. Changes and clinical significance of HbA_1c，NT-proBNP，Hcy，SOD and TC levels in patients with diabetes cardiomyopathy [J]. Laboratory Medicine, 2023, 38(3): 282-286.
[5]	AN Yinghong, YAO Kechun, SU Chengming, TANG Jinhua, YANG Lixin, GAO Jie, XU Yanting, YAN Qiuhong, ZHAN Hongyan, MA Yueyun. Survey of serum homocysteine levels of apparently healthy subjects in Beijing [J]. Laboratory Medicine, 2023, 38(11): 1036-1040.
[6]	CHANG Huijun, ZHANG Min, ZHANG Qixiang. Correlation between serum homocysteine level and short-term prognosis of acute cerebral infarction patients receiving intravenous thrombolysis [J]. Laboratory Medicine, 2023, 38(11): 1057-1061.
[7]	JIN Zhonggan, JU Yi, ZHANG Sujie. Analysis of homocysteine trueness verification results in 2021 [J]. Laboratory Medicine, 2023, 38(10): 967-970.
[8]	SHEN Jianguo, LI Tingting, SONG Yunxiao, BIAN Xiaobo, ZHANG Linlin, JIN Xiaoling. Clinical role of blood lipid in brittle fracture elderly patients with osteoporosis [J]. Laboratory Medicine, 2022, 37(6): 535-538.
[9]	SHI Penghui, FAN Weiguang, ZHANG Zhen, SU Miaomiao, MENG Juan, LU Xinli. Dynamic changes and clinical significance of CXCR5,sPD-1 and Hcy in AIDS patients during therapy [J]. Laboratory Medicine, 2022, 37(2): 103-107.
[10]	WANG Shan, XU Minyi, WANG Wei, JIANG Mingming, LU Pei, XIONG Zhongbo, WANG Lei. Clinical value of MTHFR gene C677T polymorphism determination in patients with H-type hypertension [J]. Laboratory Medicine, 2022, 37(11): 1012-1016.
[11]	PENG Yanjun, HAN Xuejing, TANG Hongxia, CHEN Junmeng, JIA Kegang. Correlation between nuclear magnetic resonance spectroscopy and traditional biochemical determination methods analyzer for determining blood lipid [J]. Laboratory Medicine, 2021, 36(7): 733-737.
[12]	LIU Jinyan, ZHAO Juntao, XIANG Mingjie. Mechanism and application of serum amyloid A in clinical diseases [J]. Laboratory Medicine, 2021, 36(7): 756-760.
[13]	DAI Yanpeng, YUAN Enwu, LIU Junjie, LI Yushan, WANG Quanxian. Analysis of the appropriate levels of blood lipid among healthy pregnant women in Zhengzhou [J]. Laboratory Medicine, 2021, 36(6): 604-608.
[14]	LI Jing, QUAN Hui, ZENG Zhirong, WEI Yi. Establishment of the reference interval of small and dense low-density lipoprotein cholesterol in apparently healthy adults in Chengdu [J]. Laboratory Medicine, 2021, 36(6): 609-614.
[15]	WANG Linlin, FAN Jun, YE Chenyu, YING Chunmei. Correlation between blood lipid and carotid atherosclerotic plaque in elderly patients with coronary heart disease [J]. Laboratory Medicine, 2021, 36(6): 618-622.