Receiver operating characteristic curve for free fatty acid determination in patients with coronary heart disease

doi:10.3969/j.issn.1673-8640.2017.05.004

Abstract

Abstract:

Objective To investigate the correlation of free fatty acid （FFA）with coronary heart disease （CHD）. Methodse A total of 110 patients with CHD,71 disease controls and 50 healthy subjects（healthy control group） were enrolled. Serum FFA,homocysteine（Hcy）,triglyceride（TG）,total cholesterol（TC） and lipoprotein（a）[Lp（a）] levels were determined. Receiver operating characteristic（ROC）curve was used to evaluate the diagnosis performance of each index. Results FFA,Hcy,TG and Lp（a）levels in CHD group were higher than those in healthy control group（P<0.01） and disease control group（P<0.05,P<0.01）,those in disease control group were higher than those in healthy control group （P<0.01）. TC had no statistical significance among the 3 groups （P>0.05）. The optimal cut-off value of FFA for the diagnosis of CHD was 596.20 μmol/L,the area under ROC curve was 0.924,the sensitivity was 85.5%,and the specificity was 90.1%. The diagnosis performance of FFA was superior to those of Hcy,TG,Lp（a） and TC. Conclusions FFA plays a role in the diagnosis of CHD.

Key words: Free fatty acid, Coronary heart disease, Homocysteine, Blood lipid

CLC Number:

R446.1

GU Keping, WANG Yaping, YU Wei, ZHANG Min, GONG Mengjiao, JIANG Yuhai. Receiver operating characteristic curve for free fatty acid determination in patients with coronary heart disease[J]. Laboratory Medicine, 2017, 32(5): 367-369.

Figures/Tables 3

References 10

[1]	马会利,胡桃红,邹建宏,等. 国人男女冠心病发病危险因素分析[J]. 心血管康复医学杂志,2011,20(6):517-519.
[2]	李斌,余绮玲,钟向红. 2型糖尿病伴冠心病患者胰岛素抵抗与游离脂肪酸关系研究[J]. 临床荟萃,2008,23(1):13-15.
[3]	郝亚平,马晓静,周密,等. 血清游离脂肪酸水平与冠状动脉病变的相关性[J]. 复旦学报(医学版),2012,39(5):465-469.
[4]	邵俊良,孙剑,韦勇,等. 冠心病患者血清同型半胱氨酸和脂蛋白a联合检测的临床意义[J]. 国际检验医学杂志,2015,36(2):255-256.
[5]	CUI Z,ZHONG S,XU P,et al.PANDA:a pipeline toolbox for analyzing brain diffusion images[J]. Front Hum Neurosci,2013,7:42.
[6]	张岩,陈晓亭,宋惠珠,等. 肥胖所导致的胰岛素抵抗分子机制的研究进展[J]. 检验医学,2014,29(7):774-778.
[7]	陈效琴,任静. 游离脂肪酸、胰岛素抵抗与代谢综合征相关因素的关系[J]. 检验医学,2016,31(7):553-558.
[8]	袁云龙,吴嘉,宋佳希,等. 冠心病患者血清游离脂肪酸、氧化脂蛋白(a)与冠状动脉病变程度的关系[J]. 临床检验杂志,2015,33(2):99-103.
[9]	GHASSIBE-SABBAGH M,PLATT D E,YOUHANNA S,et a1.Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk[J].Atherosclerosis,2012,222(1):180-186.
[10]	常志红,杨志明. 脂蛋白(a)和TG/HDL-C比值与冠心病的相关性研究[J]. 长治医学院学报,2014,28(1):43-45.

组别	例数	FFA（μmol/L）	Hcy（μmol/L）	TG（mmol/L）	TC（mmol/L）	Lp（a）（mg/L）
CHD组	110	954.41±400.52^*##	15.1（11.8~21.2）^*##	1.78（1.09~2.74）^*##	4.28±1.20	151.10（93.00~273.90）^*#
疾病对照组	50	238.97±134.07	7.30（6.30~8.93）	0.90（0.73~1.07）	4.28±0.51	48.65（31.65~85.23）
正常对照组	71	403.12±167.67^*	11.80（10.30~14.90）	1.23（0.89~1.85）^*	4.16±0.88	100.60（71.60~205.70）^*

组别	例数	FFA（μmol/L）	Hcy（μmol/L）	TG（mmol/L）	TC（mmol/L）	Lp（a）（mg/L）
CHD组	110	954.41±400.52^*##	15.1（11.8~21.2）^*##	1.78（1.09~2.74）^*##	4.28±1.20	151.10（93.00~273.90）^*#
疾病对照组	50	238.97±134.07	7.30（6.30~8.93）	0.90（0.73~1.07）	4.28±0.51	48.65（31.65~85.23）
正常对照组	71	403.12±167.67^*	11.80（10.30~14.90）	1.23（0.89~1.85）^*	4.16±0.88	100.60（71.60~205.70）^*

项目	敏感性（%）	特异性（%）	最佳临界值	标准误	ROC曲线下面积	95%可信区间
FFA	85.5	90.1	596.20 μmol/L	0.019	0.924	0.887~0.960
Hcy	66.4	59.2	13.25 μmol/L	0.039	0.693	0.617~0.769
TG	22.7	93.0	2.96 mmol/L	0.042	0.636	0.554~0.718
TC	37.3	73.2	4.50 mmol/L	0.044	0.531	0.445~0.616
Lp（a）	64.5	60.6	122.95 mg/L	0.043	0.603	0.519~0.688

项目	敏感性（%）	特异性（%）	最佳临界值	标准误	ROC曲线下面积	95%可信区间
FFA	85.5	90.1	596.20 μmol/L	0.019	0.924	0.887~0.960
Hcy	66.4	59.2	13.25 μmol/L	0.039	0.693	0.617~0.769
TG	22.7	93.0	2.96 mmol/L	0.042	0.636	0.554~0.718
TC	37.3	73.2	4.50 mmol/L	0.044	0.531	0.445~0.616
Lp（a）	64.5	60.6	122.95 mg/L	0.043	0.603	0.519~0.688

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