Abstract:

Objective To determine the levels of lymphocyte subsets and platelet（PLT） in peripheral blood of breast cancer patients,and to investigate their correlations with clinicopathological characteristics of breast cancer. Methods A total of 92 patients with primary invasive breast cancer were enrolled,and 50 healthy subjects were enrolled as control group. PLT level was determined by hematology analyzer. The levels of lymphocyte subset CD3⁺,CD4⁺ and CD8⁺were determined by flow cytometry. Results Compared with control group,the levels of CD3⁺ and CD4⁺ were decreased,while CD8⁺ and PLT levels were increased（P<0.01）. There was no statistical significance for the levels of CD3⁺ and CD8⁺ in different clinicopathological characteristics of breast cancer（P>0.05）. The levels of CD4⁺ and PLT had no statistical significance with age,tumor size and pathological pattern（P>0.05）,but they had statistical significance with histological grade and lymph node metastasis（P<0.01）. The levels of CD4⁺ and PLT had negative correlation [coefficient of rank correlation（rs）=-0.43,P<0.01]. Conclusions Low level of CD4⁺ and high level of PLT in peripheral blood of breast cancer patients have negative correlation,which are related to histological grade and lymph node metastasis.

Key words: Breast cancer, Peripheral blood, Lymphocyte, Platelet