Expression of survivin and CD34 in bone marrow cells of patients with acute myeloid leukemia

doi:10.3969/j.issn.1673-8640.2013.01.013

Abstract

Abstract: Objective　To investigate the relationship of bone marrow cell expression of survivin and cluster of differentiation 34（CD34）in the development of acute myeloid leukemia（AML). Methods　The survivin and CD34 were detected by flow cytometry in 62 patients with AML and 31 patients with non-malignant hematopathy. Results　The percentage of the expression of survivin^＋/CD34^＋ in bone marrow cells of patients with AML [(13.74±10.92)%] was obviously higher than that of control group [(2.53±1.85)%，P＜0.01]，and that of remission group [(4.01±1.41）%] was lower than that of non-remission group[(23.83±20.42)%，P＜0.01]. The percentage of the expression of survivin^＋/CD34- in bone marrow cells of patients with AML [(22.07±16.95)%] was obviously higher than that of control group [(12.29±8.80)%，P＜0.05]，and that of remission group [(14.32±7.53)%] was lower than that of non-remission group [(29.83±26.37)%，P＜0.05]. Conclusions　In the detection of hematopathy，the expression of survivin in bone marrow cells has the role of outcome with screening. The expression of survivin has closer relationship with the development of leukemia than CD34，and has a certain significance in the treatment and prognosis assessment of AML.

Key words: Survivin, Cluster of differentiation 34, Acute myeloid leukemia, Flow cytometry

GU Dawei，MA Li. Expression of survivin and CD34 in bone marrow cells of patients with acute myeloid leukemia[J]. , 2013, 28(1): 51-56.

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