Meta-analysis on the correlation of peptidyl arginine deiminase 4 single nucleotide polymorphisms and rheumatoid arthritis

Abstract

Abstract: Objective　To investigate the relationship between the peptidyl arginine deiminase 4 (PADI4) gene single nucleotide polymorphisms and the risk of rheumatoid arthritis(RA). Methods　Meta-analysis was performed to estimate the pooled odd ratio to assess the risk of RA associated with PADI4 gene polymorphisms. The heterogeneity test，bias evaluation and risk ratio on Meta-analysis were performed. Results　A total of 13 literature studies with 11 039 cases and 10 395 controls were included for Meta-analysis based on criteria. According to heterogeneity test，Asian and European groups were analyzed respectively for PADI4-94 using fixed effect model，and the same model was used to PADI4-104 with one study having heterogeneity. The results of Meta-analysis showed PADI4-94 single nucleotide polymorphisms were associated with the risk of RA for Asian people，but not with that for European people，and PADI4-104 single nucleotide polymorphisms had the high risk of RA for all. Bias analysis confirmed the conclusion by trim and fill method. Conclusions　PADI4-94 and PADI4-104 single nucleotide polymorphisms are associated with the risk of RA.

Key words: Peptidyl arginine deiminase 4, Single nucleotide polymorphism, Rheumatoid arthritis, Meta-analysis

XU Poshi;SHAO Fengmin;SUN Changyi;QIN Wangsen;HU Hong . Meta-analysis on the correlation of peptidyl arginine deiminase 4 single nucleotide polymorphisms and rheumatoid arthritis[J]. , 2012, 27(9): 707-712.

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