Abstract: Objective　To investigate the influence of lipemia on the main parameters of Sysmex XE-2100D hematology analyzer.   Methods　A total of 20 samples without hemolysis，jaundice and lipemia were setas control group. The upper plasma was removed，and equal volume reagent diluent of Sysmex XE-2100D hematology analyzer was added. These samples were performed as experiment group，and the results were compared with those of the control group. A total of 66 routine blood samples without hemolysis，jaundice and lipemia were randomly classified into 3 groups. These samples were treated by removing 10，50 and 100 μL plasma and adding equal volume offatemulsion，and then the levels of triglyceride（TG） were determined by Hitachi 7600 automatic biochemistry analyzer. Lipemia level was classified based on TG level. A total of 21 samples（TG 6.0- 10.0 mmol/L） were setas low lipemia group，and original samples withoutfatemulsion were setas control A. A total of 21 samples（TG 10.1 -14.0 mmol/L） were setas moderate lipemia group，and original samples withoutfatemulsion were setas control B. A total of 24 samples（TG >14.0 mmol/L） were setas high lipemia group，and original samples withoutfatemulsion were setas control C. The detection results of different lipemia level groups were compared with the results of control groups. Results　In the low lipemia group，the main parameters of blood routine test showed no statistical significance comparing to control A. Comparing to control B and C，hemoglobin（HGB），mean cell hemoglobin（MCH），mean corpuscular hemoglobin concentration（MCHC） and white blood cell（WBC） increased significantly in the moderate and high lipemia groups，respectively（P＜0.05）. Conclusions　The moderate and high lipemia levels of blood can influence significantly the results of blood routine testby Sysmex XE-2100D hematology analyzer. HGB，MCH，MCHC and WBC increase parallelly with the increase of lipemia level.

Key words: Lipemia, Hematology analyzer, Influence assessment