Correlation between metabolic syndrome and moderate-to-severe periodontitis complicated with psoriasis

doi:10.3969/j.issn.1673-8640.2022.02.006

Abstract

Abstract:

Objective To investigate the correlation between metabolic syndrome（MS） and moderate-to-severe periodontitis complicated with psoriasis. Methods A total of 50 patients with moderate-to-severe periodontitis,50 patients with psoriasis and 50 patients with moderate-to-severe periodontitis complicated with psoriasis were enrolled. Totally,50 healthy subjects were enrolled as control group. Blood pressure,glycated hemoglobin A_1c（HbA_1c）,glucose（Glu）,triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） were determined. Multivariate Logistic regression analysis was used to assess the risk factors for disease development in each group. Results TC and LDL-C in moderate-to-severe periodontitis group and psoriasis group were higher than those in control group（P<0.05）. TG,LDL-C,TC and HbA_1c were higher in moderate-to-severe periodontitis complicated with psoriasis group than those in moderate-to-severe periodontitis group（P<0.05）,and TG,LDL-C and TC were higher than those in psoriasis group（P<0.05）. In moderate-to-severe periodontitis complicated with psoriasis group,TG,LDL-C,TC,Glu and HbA_1c were higher than those in control group（P<0.01）. Multivariate Logistic regression analysis showed that elevated LDL-C was a risk factor for the development of moderate-to-severe periodontitis [odds ratio（OR）=1.873,95% confidence interval（CI） 1.113-3.154],elevated TC was a risk factor for the development of psoriasis（OR=1.527,95%CI 1.012-2.304）,and elevated TC and HbA_1c were risk factors for the development of moderate-to-severe periodontitis complicated with psoriasis（OR=2.728 and 3.108,95%CI 1.572-4.732 and 1.283-7.533,respectively）. Conclusions Patients with moderate-to-severe periodontitis complicated with psoriasis show more significant disorders of MS-related components than patients with periodontitis or psoriasis alone,and elevated TC and HbA_1c are risk factors for the development of moderate-to-severe periodontitis complicated with psoriasis.

Key words: Metabolic syndrome, Periodontitis, Psoriasis

CLC Number:

R446.1

CHEN Liang, LI Lin, LI Xia, ZHANG Yan, WU Jiongrui, GAO Yiming. Correlation between metabolic syndrome and moderate-to-severe periodontitis complicated with psoriasis[J]. Laboratory Medicine, 2022, 37(2): 126-129.

Figures/Tables 4

References 17

[1]	EKE P I, DYE B A, WEI L, et al. Prevalence of periodontitis in adults in the United States:2009 and 2010[J]. J Dent Res, 2012, 91(10):914-920. DOI URL
[2]	MICHALEK I M, LORING B, JOHN S M. A systematic review of worldwide epidemiology of psoriasis[J]. J Eur Acad Dermatol Venereol, 2017, 31(2):205-212. DOI URL
[3]	FORD E S, GILES W H, DIETZ W H. Prevalence of the metabolic syndrome among US adults:findings from the third National Health and Nutrition Examination Survey[J]. JAMA, 2002, 287(3):356-359. DOI URL
[4]	GOBIN R, TIAN D, LIU Q, et al. Periodontal diseases and the risk of metabolic syndrome:an updated systematic review and meta-analysis[J]. Front Endocrinol(Lausanne), 2020, 11:336.
[5]	ARMSTRONG A W, HARSKAMP C T, ARMSTRONG E J. Psoriasis and metabolic syndrome:a systematic review and meta-analysis of observational studies[J]. J Am Acad Dermatol, 2013, 68(4):654-662. DOI URL
[6]	RODRÍGUEZ-ZÚÑIGA M J M, GARCÍA-PERDOMO H A. Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome[J]. J Am Acad Dermatol, 2017, 77(4):657-666.e8. DOI URL
[7]	中华医学会皮肤性病学分会银屑病专业委员会. 中国银屑病诊疗指南(2018完整版)[J]. 中华皮肤科杂志, 2019, 52(10):667-710.
[8]	PAGE R C, EKE P I. Case definitions for use in population-based surveillance of periodontitis[J]. J Periodontol, 2007, 78(7 Suppl):1387-1399. DOI URL
[9]	ARMSTRONG A W, HARSKAMP C T, ARMSTRONG E J. The association between psoriasis and hypertension:a systematic review and meta-analysis of observational studies[J]. J Hypertens, 2013, 31(3):433-442. DOI URL
[10]	ARMSTRONG A W, HARSKAMP C T, ARMSTRONG E J. Psoriasis and the risk of diabetes mellitus:a systematic review and meta-analysis[J]. JAMA Dermatol, 2013, 149(1):84-91. DOI URL
[11]	SKUDUTYTE-RYSSTAD R, SLEVOLDEN E M, HANSEN B F, et al. Association between moderate to severe psoriasis and periodontitis in a Scandinavian population[J]. BMC Oral Health, 2014, 14:139. DOI URL
[12]	UNGPRASERT P, WIJARNPREECHA K, WETTER D A. Periodontitis and risk of psoriasis:a systematic review and meta-analysis[J]. J Eur Acad Dermatol Venereol, 2017, 31(5):857-862. DOI URL
[13]	GERDES S, ROSTAMI-YAZDI M, MROWIETZ U. Adipokines and psoriasis[J]. Exp Dermatol, 2011, 20(2):81-87. DOI URL
[14]	TORRES T, SELORES M. Does treatment of metabolic syndrome components improve psoriasis? Report of three cases[J]. Eur J Dermatol, 2012, 22(2):270-272. DOI URL
[15]	HOLZER M, WOLF P, INZINGER M, et al. Anti-psoriatic therapy recovers high-density lipoprotein composition and function[J]. J Invest Dermatol, 2014, 134(3):635-642. DOI URL
[16]	SAITO T, MURAKAMI M, SHIMAZAKI Y, et al. Association between alveolar bone loss and elevated serum C-reactive protein in Japanese men[J]. J Periodontol, 2003, 74(12):1741-1746. DOI URL
[17]	LÓPEZ N J, QUINTERO A, CASANOVA P A, et al. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome:a controlled clinical trial[J]. J Periodontol, 2012, 83(3):267-278. DOI URL

组别	例数	TC/ （mmol/L）	TG/ （mmol/L）	LDL-C/ （mmol/L）	HDL-C/（mmol/L）	Glu/ （mmol/L）	HbA_1c/%	收缩压/kPa
正常对照组	50	4.67±1.03	1.53±0.41	2.86±0.90	1.23±0.22	5.43±0.70	5.50±0.52	16.61±2.31
牙周炎组	50	5.10±0.85^*	1.60±0.43	3.26±0.70^*	1.22±0.23	5.68±0.57	5.61±0.53	16.53±2.21
银屑病组	50	5.09±0.99^*	1.57±0.50	3.24±0.75^*	1.23±0.22	5.61±0.57	5.67±0.43	16.62±1.93
牙周炎合并银屑病组	50	5.48±0.94^**#△	1.83±0.53^**#△	3.55±0.71^**#△	1.21±0.24	5.88±0.81^**	5.86±0.57 ^**#	17.40±2.56

组别	例数	TC/ （mmol/L）	TG/ （mmol/L）	LDL-C/ （mmol/L）	HDL-C/（mmol/L）	Glu/ （mmol/L）	HbA_1c/%	收缩压/kPa
正常对照组	50	4.67±1.03	1.53±0.41	2.86±0.90	1.23±0.22	5.43±0.70	5.50±0.52	16.61±2.31
牙周炎组	50	5.10±0.85^*	1.60±0.43	3.26±0.70^*	1.22±0.23	5.68±0.57	5.61±0.53	16.53±2.21
银屑病组	50	5.09±0.99^*	1.57±0.50	3.24±0.75^*	1.23±0.22	5.61±0.57	5.67±0.43	16.62±1.93
牙周炎合并银屑病组	50	5.48±0.94^**#△	1.83±0.53^**#△	3.55±0.71^**#△	1.21±0.24	5.88±0.81^**	5.86±0.57 ^**#	17.40±2.56

项目	β值	标准误	Wald值	OR值（95%CI）	P值
TC	0.106	2.112	0.000	1.006（0.016~63.195）	0.745
TG	0.013	0.809	0.000	1.006（0.206~4.915）	0.910
LDL-C	0.526	0.266	5.581	1.873（1.113~3.154）	0.018
HDL-C	0.278	2.241	0.036	0.652（0.008~52.732）	0.598
Glu	2.151	0.516	2.132	2.123（0.773~5.833）	0.143
HbA_1c	0.399	0.624	0.299	0.711（0.209~2.414）	0.527
收缩压	0.158	0.013	0.587	0.990（0l965~1.016）	0.691

项目	β值	标准误	Wald值	OR值（95%CI）	P值
TC	0.106	2.112	0.000	1.006（0.016~63.195）	0.745
TG	0.013	0.809	0.000	1.006（0.206~4.915）	0.910
LDL-C	0.526	0.266	5.581	1.873（1.113~3.154）	0.018
HDL-C	0.278	2.241	0.036	0.652（0.008~52.732）	0.598
Glu	2.151	0.516	2.132	2.123（0.773~5.833）	0.143
HbA_1c	0.399	0.624	0.299	0.711（0.209~2.414）	0.527
收缩压	0.158	0.013	0.587	0.990（0l965~1.016）	0.691

项目	β值	标准误	Wald值	OR值（95%CI）	P值
TC	0.423	0.210	4.361	1.527（1.012~2.304）	0.044
TG	0.056	0.658	0.474	0.636（0.175~2.307）	0.813
LDL-C	0.140	1.884	0.030	0.721（0.018~28.933）	0.282
HDL-C	0.495	2.087	0.702	0.174（0.003~10.401）	0.482
Glu	1.740	0.473	0.129	1.186（0.469~2.998）	0.187
HbA_1c	2.184	0.624	0.622	1.636（0.481~5.560）	0.139
收缩压	0.058	0.013	0.110	0.996（0.970~1.022）	0.810